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  4. Recombinant Dog Toll-like receptor 9 (TLR9), partial

Recombinant Dog Toll-like receptor 9 (TLR9), partial

  • 中文名稱：
    熟悉的犬TLR9重組蛋白
  • 貨號：
    CSB-YP023608DO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    熟悉的犬TLR9重組蛋白
  • 貨號：
    CSB-EP023608DO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    熟悉的犬TLR9重組蛋白
  • 貨號：
    CSB-EP023608DO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    熟悉的犬TLR9重組蛋白
  • 貨號：
    CSB-BP023608DO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    熟悉的犬TLR9重組蛋白
  • 貨號：
    CSB-MP023608DO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    TLR9; Toll-like receptor 9; CD antigen CD289
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
  • 基因功能參考文獻：
    1. These findings do not support a role for non-synonymous SNPs in the TLR 2, 4 and 9 coding regions in the pathogenesis of canine SNA, but do not exclude a role for innate immunity in the pathogenesis of the disease. PMID: 25266752
    2. Study investigated the pattern of TLR-2, TLR-4 and TLR-9 gene expression in brain, choroid plexus, spleen and lymph node of dogs naturally infected with Leishmania infantum. In the brain, there was only an upregulation of TLR-2, in the choroid plexus, TLR-2 and TLR-9 were both upregulated and peripheral lymphoid organs showed increased TLR-2 and TLR-4 expression. PMID: 25283216
    3. The aim of this study was to investigate the expression of TLR2 and TLR9 in jejunum and colon in dogs naturally infected with Leishmania infantum. PMID: 23668673
    4. we studied TLR9 expression in lung extracts from pigs, dogs, and cattle. PMID: 21044185
    5. The amino acid sequence of canine TLR9, its homology with TLR9 from other species, and its expression in various tissues are reported. PMID: 15911003

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome.
  • 蛋白家族：
    Toll-like receptor family
  • 數據庫鏈接：


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