在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Dog Ras-related C3 botulinum toxin substrate 1 (RAC1)

Recombinant Dog Ras-related C3 botulinum toxin substrate 1 (RAC1)

  • 中文名稱：
    熟悉的犬RAC1重組蛋白
  • 貨號(hào)：
    CSB-YP019242DO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    熟悉的犬RAC1重組蛋白
  • 貨號(hào)：
    CSB-EP019242DO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    熟悉的犬RAC1重組蛋白
  • 貨號(hào)：
    CSB-EP019242DO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    熟悉的犬RAC1重組蛋白
  • 貨號(hào)：
    CSB-BP019242DO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    熟悉的犬RAC1重組蛋白
  • 貨號(hào)：
    CSB-MP019242DO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    RAC1; Ras-related C3 botulinum toxin substrate 1; EC 3.6.5.2; Rac2; p21-Rac1
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-189
  • 氨基酸序列
    MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE VRHHCPNTPI ILVGTKLDLR DDKDTIEKLK EKKLTPITYP QGLAMAKEIG AVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKRKRKC
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In neurons, is involved in dendritic spine formation and synaptic plasticity. In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization.
  • 基因功能參考文獻(xiàn)：
    1. Live cell imaging with cell cycle indicators showed that expression of Rac1V12, but not the wild-type Rac1 or Rac1b, promoted cell cycle progression. The expression of Rac1b per se cannot induce cell proliferation. PMID: 23411476
    2. Silencing tight junction protein ZO-2 alters epithelial cytoarchitecture.ZO-2 silencing increases RhoA activity through GEF-H1 recruitment to cell borders.ZO-2 silencing activates Cdc42 and triggers mitotic spindle disorientation. ZO-2 silencing increases Rac1 and cofilin activity and lamellipodia formation. PMID: 28554775
    3. Data indicate exosomal Rac1/PAK2 as angiogenic promoters. PMID: 26919098
    4. This inversion of glandular orientation is accompanied by Rac1 inactivation during early cystogenesis, and temporal activation of Rac1 is sufficient to recover the normal cyst phenotype. PMID: 23051733
    5. These results indicate that cadherins and nectins cooperate to induce and then rapidly suppress Rac1 activity during initial cell-cell adhesion. PMID: 21412440
    6. Numb acts to suppress Rac1-GTP accumulation, and its loss leads to increased sensitivity toward extracellular signals that disrupt cell-cell adhesion to induce epithelial-mesenchymal transition (EMT) and cell dispersal PMID: 21147098
    7. Rac activation by cadherin through the c-Src-Rap1-phosphatidylinositol 3-kinase-Vav2 pathway PMID: 16170364
    8. these results provide the first evidence for a role of Rac1/Cdc42 signalling during early HSV-1 infection and suggest a mechanism relying on virus-induced regulation of Rac1/Cdc42 activities. PMID: 17098962
    9. ARF6 regulates the subcellular distribution of the GTPase, Rac1, to tubule extensions. ARF6-induced ERK activation regulates Rac1 activation during tubule initiation through the expression of the receptor for urokinase type plasminogen activator. PMID: 17363898
    10. Data show that zones of Rac1 and lamellipodia activity and of RhoA and actomyosin contractility are restricted to the periphery of contacting membranes and together drive initiation, expansion, and completion of cell-cell adhesion. PMID: 17646397
    11. Phosphoinositide 3'-kinase is required for apical membrane protein remodeling from the initial apical membrane surface. Both Rac1 and atypical PKC are required for reorientation of cellular polarity. PMID: 17804488
    12. phosphatidylinositol 3-kinase and Rac1 are transiently activated by E-cadherin engagement and initiate a new round of membrane dynamics, but they are subsequently suppressed at that site to allow maintenance of weak E-cadherin mediated adhesion. PMID: 18089563
    13. Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions PMID: 18653465
    14. as a mediator of SF- and Src-stimulated NF-kappaB activity. Finally, the Src/Rac1/MKK3/6/p38 and Src/TAK1/NF-kappaB-inducing kinase pathways exhibited cross-talk at the level of MKK3. PMID: 19047046

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasm. Cell projection, lamellipodium. Cell projection, dendrite. Cell junction, synapse.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 數(shù)據(jù)庫鏈接：

    KEGG: cfa:403955

    UniGene: Cfa.40290



主站蜘蛛池模板： 精品国产一区二区三区久久狼| 国产麻豆md传媒视频| 蜜臀aⅴ国产精品久久久国产老师| 亚洲人成网站日本片| 久久青草成人综合网站| 五月天精品视频在线观看| 好吊妞视频这里有精品| 海角社区在线视频播放观看 | 无码三级在线看中文字幕完整版| 无码人妻少妇色欲av一区二区 | 亚洲中文字幕无码mv| 亚洲欧洲∨国产一区二区三区| 国产精品夜夜春夜夜爽久久| 99国精品午夜福利视频不卡| 亚洲国产长腿丝袜av天堂| 国产va免费精品高清在线| 色欲来吧来吧天天综合网| 人与动人物xxxx毛片| 国产福利一区二区三区在线观看| 亚洲中文字幕无码久久2020| 国产欧美日韩久久久久| 亚洲欭美日韩颜射在线| 2019nv天堂香蕉在线观看| 欲求不满邻居的爆乳在线播放| 日本xxxx丰满老妇| 人人爽人人爽人人爽| 欧美最猛黑人xxxx| 亚洲精品卡2卡三卡4卡2卡乱码 | 好疼太大了太粗太长了视频| 少妇人妻邻居| 亚洲午夜无码久久久久蜜臀av| 久久无码精品一一区二区三区| 国产成人免费永久在线平台| 国产欧美久久一区二区三区 | 中文中幕a在线| 亚洲国产精品成人影片久久| 麻豆成人精品国产免费| 男女吃奶做爰猛烈紧视频 | 成人无码精品免费视频在线观看| 久久综合伊人| 在线播放无码后入内射少妇|