在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Dog Platelet-derived growth factor receptor beta (PDGFRB), partial

  • 中文名稱:
    熟悉的犬PDGFRB重組蛋白
  • 貨號:
    CSB-YP764838DO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    熟悉的犬PDGFRB重組蛋白
  • 貨號:
    CSB-EP764838DO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    熟悉的犬PDGFRB重組蛋白
  • 貨號:
    CSB-EP764838DO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    熟悉的犬PDGFRB重組蛋白
  • 貨號:
    CSB-BP764838DO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    熟悉的犬PDGFRB重組蛋白
  • 貨號:
    CSB-MP764838DO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; EC 2.7.10.1; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD antigen CD140b
  • 種屬:
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
  • 基因功能參考文獻:
    1. PDGFbetaR was expressed and hyperphosphorylated in the majority of tumour samples and tumour derived cell lines. Additionally, both MEK and ERK were expressed and activated in cell lines as well as biopsies. PMID: 28159233
    2. The aim of this study was to investigate the role of PDGF-A, PDGF-B, PDGFR-alpha and PDGFR-beta in canine lymphoma PMID: 25172054
    3. PDGFR-beta may be associated with the malignant nature of hemangiosarcoma PMID: 22419024
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲国产专区校园欧美| 狠狠躁夜夜躁人人爽天天天天97| 国产无线乱码一区二三区| 欧美日韩国产亚洲沙发| 国产亚洲精品自在久久vr| 国产欧美一区二区三区免费视频| 国模叶桐尿喷337p人体| 久久精品成人免费国产| 护士av无码在线观看| 国产疯狂伦交大片| 国产又粗又硬又大爽黄老大爷视| 亚洲性视频免费视频网站| 中国丰满熟妇av| 特级毛片内射www无码| 欧美日韩免费做爰大片人| 国产福利姬喷水福利在线观看| av性色av久久无码ai换脸| 熟女人妻水多爽中文字幕| 色综合av综合无码综合网站| 成人网站色52色在线观看| 亚洲综合激情另类专区| 92国产精品午夜福利| 日本熟妇人妻xxxxx人hd| 久久精品国产国产精品四凭| 一本色道久久88加勒比—综合| av香港经典三级级 在线| 伊人久久久av老熟妇色| 公与淑婷厨房猛烈进出视频免费| 人妻无码一区二区三区四区| 精品国产乱码久久久久软件| 十八禁午夜福利免费网站| 西西人体444www高清大胆| 亚洲欧美中文日韩在线v日本| 无码专区—va亚洲v天堂麻豆| 再深点灬舒服灬太大了在线视频 | 欧美熟妇性xxxx交潮喷| 亚洲精品久久久久午夜福禁果tⅴ| 国产熟妇搡bbbb搡bbbb| 国产亚洲香蕉线播放αv38| 亚洲精品国产一区二区的区别| 久久五月精品中文字幕|