在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Dog Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Recombinant Dog Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

  • 中文名稱：
    熟悉的犬PTEN重組蛋白
  • 貨號(hào)：
    CSB-YP018964DO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    熟悉的犬PTEN重組蛋白
  • 貨號(hào)：
    CSB-EP018964DO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    熟悉的犬PTEN重組蛋白
  • 貨號(hào)：
    CSB-EP018964DO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    熟悉的犬PTEN重組蛋白
  • 貨號(hào)：
    CSB-BP018964DO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    熟悉的犬PTEN重組蛋白
  • 貨號(hào)：
    CSB-MP018964DO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    PTEN; MMAC1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    2-403
  • 氨基酸序列
    TAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKFMY FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHTQI TKV
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.
  • 基因功能參考文獻(xiàn)：
    1. The data suggest that overexpression of STAT3 and downregulation of PTEN may be an important step in canine prostate carcinogenesis PMID: 27401955
    2. These data suggest that inhibition of lipoxygenases and off target oxidation in osteosarcoma cells play roles in the apoptotic response. PMID: 24813477
    3. All the hyperplastic samples stained positive for both markers, 100% of adenomas were positive for PTEN and 86% for E-cadherin, and 69% and 34% of carcinomas were positive for PTEN and E-cadherin, respectively. PMID: 26679805
    4. The presence of PTEN abnormalities that could contribute to the progression of naturally occurring canine hemangiosarcomas are reported. PMID: 16145208
    5. p21 plays a key role in mechanisms used by PTEN-deficient tumors to escape chemotherapy PMID: 17300726
    6. Low-level PETN expression might play an important role in carcinogenesis and the progression of canine mammary tumours, and PTEN protein detection might be useful in evaluating tumour development and prognosis. PMID: 18082231
    7. Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis is reported. PMID: 18172008
    8. The relationship between the expression of the PTEN and VEGF and the clinicopathological features in canine mammary gland tumours are reported. PMID: 18461467
    9. increased PTEN expression and activity play a central role in PI3K/Akt/GSK3beta and p70S6K pathway modulation, which could exacerbate the consequences of dystrophin deficiency. PMID: 19264909

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Nucleus, PML body.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 中文字幕乱码亚洲无线三区| 欧美刺激性大交| 波多野结衣在线精品视频| 99久久综合狠狠综合久久| www亚洲精品久久久乳| 久久国产欧美日韩精品图片| 亚洲精品乱码久久久久久| 国产成人亚洲高清一区| 五月综合缴情婷婷六月| 野花社区免费观看在线www| 老司机在线精品视频播放| 少妇做爰免费视频了| 18禁女裸乳扒开免费视频| 开心五月综合亚洲| 中文字幕奈奈美被公侵犯| 人人妻人人超人人| 色婷婷六月亚洲综合香蕉| 国产精品va无码一区二区| 欧美丰满熟妇xxxxx| 国产精品一区二区av蜜芽| 狠狠色噜噜狠狠狠狠蜜桃| 女厕厕露p撒尿八个少妇| 996热re视频精品视频这里| 窝窝影院午夜看片| 曰韩欧美群交p片内射| 亚洲vs成人无码人在线观看堂| 久久九九精品国产av片国产| 国产乱码一区二区三区爽爽爽 | 中文乱码免费一区二区三区 | 5566先锋影音夜色资源站在线观看| 野狼av午夜福利在线| 婷婷色香合缴缴情av第三区| 国产精品麻豆aⅴ人妻| 又色又爽又黄的视频日本| 自拍偷自拍亚洲精品被多人伦好爽| 中文字幕在线观看亚洲视频| 国产精品爆乳奶水无码视频免费| 先锋人妻无码av电影 | 一边摸一边抽搐一进一出视频| 熟妇的味道hd中文字幕| 伊人久久成综合久久影院|