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Recombinant Dog Orexin receptor type 2 (HCRTR2), partial

  • 中文名稱:
    熟悉的犬HCRTR2重組蛋白
  • 貨號:
    CSB-YP880008DO1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    熟悉的犬HCRTR2重組蛋白
  • 貨號:
    CSB-EP880008DO1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    熟悉的犬HCRTR2重組蛋白
  • 貨號:
    CSB-EP880008DO1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    熟悉的犬HCRTR2重組蛋白
  • 貨號:
    CSB-BP880008DO1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    熟悉的犬HCRTR2重組蛋白
  • 貨號:
    CSB-MP880008DO1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    HCRTR2; Orexin receptor type 2; Ox-2-R; Ox2-R; Ox2R; Hypocretin receptor type 2
  • 種屬:
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
  • 基因功能參考文獻:
    1. A mutation in the Hcrtr2 gene alters the normal developmental course of hypocretin-1 levels. PMID: 15308685
    2. We measured hcrtR1 and hcrtR2 expression in the frontal cortex and pons using the RT-PCR method in murine models, in canine models and in humans. PMID: 18714784
  • 相關疾病:
    Defects in HCRTR2 are a cause of an autosomal recessive form of narcolepsy, observed in labradors, dobermans and dachshunds. Narcolepsy is a neurological sleep disorder affecting animals and humans, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. As in humans, most cases of canine narcolepsy are sporadic but an autosomal recessive form was also observed.
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數據庫鏈接:


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