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  4. Recombinant Dog Coagulation factor IX (F9)

Recombinant Dog Coagulation factor IX (F9)

  • 中文名稱：
    熟悉的犬F9重組蛋白
  • 貨號：
    CSB-YP007936DO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    熟悉的犬F9重組蛋白
  • 貨號：
    CSB-EP007936DO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    熟悉的犬F9重組蛋白
  • 貨號：
    CSB-EP007936DO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    熟悉的犬F9重組蛋白
  • 貨號：
    CSB-BP007936DO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    熟悉的犬F9重組蛋白
  • 貨號：
    CSB-MP007936DO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    F9Coagulation factor IX; EC 3.4.21.22; Christmas factor) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    40-452
  • 氨基酸序列
    Y NSGKLEEFVR GNLERECIEE KCSFEEAREV FENTEKTTEF WKQYVDGDQC ESNPCLNDGV CKDDINSYEC WCRAGFEGKN CELDVTCNIK NGRCKQFCKL GPDNKVVCSC TTGYQLAEDQ RSCEPAVPFP CGRVSVPHIS MTRTRAETLF SNMDYENSTE VEKILDNVTQ PLNDFTRVVG GKDAKPGQFP WQVLLNGKVD AFCGGSIINE KWVVTAAHCI EPDVKITIVA GEHNTEKREH TEQKRNVIRT ILHHSYNATI NKYNHDIALL ELDEPLTLNS YVTPICIADR EYSNIFLKFG SGYVSGWGRV FNKGRSASIL QYLKVPLVDR ATCLRSTKFT IYNNMFCAGF HEGGKDSCQG DSGGPHVTEV EGISFLTGII SWGEECAMKG KYGIYTKVSR YVNWIKEKTK LT
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
  • 基因功能參考文獻：
    1. Report relative sensitivity of whole blood clotting time and activated partial thromboplastin time for the detection of factor IX. PMID: 22482117
    2. Data indicate that the hyperactivating factor IX (FIX)-R338L mutation resulted in a robust 15-fold gain in potency and therefore provides a promising strategy to improve the efficacy, feasibility, and safety of hemophilia gene therapy. PMID: 23043073
    3. Data indicate that factor IX (FIX)-R338L provides an attractive strategy to safely enhance the efficacy of gene therapy for hemophilia B (HB). PMID: 22919027
    4. Describe proliferation of FIX-producing dog hepatocytes in mouse liver. PMID: 18449417
  • 相關疾病：
    Defects in F9 are the cause of hemophilia B (HEMB).
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 組織特異性：
    Detected in the liver.
  • 數據庫鏈接：


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