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  4. Recombinant Danio rerio G-protein coupled receptor 126 (gpr126), partial

Recombinant Danio rerio G-protein coupled receptor 126 (gpr126), partial

  • 中文名稱：
    Recombinant Danio rerio G-protein coupled receptor 126(gpr126) ,partial
  • 貨號：
    CSB-YP009747DIL
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Danio rerio G-protein coupled receptor 126(gpr126) ,partial
  • 貨號：
    CSB-EP009747DIL
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Danio rerio G-protein coupled receptor 126(gpr126) ,partial
  • 貨號：
    CSB-EP009747DIL-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Danio rerio G-protein coupled receptor 126(gpr126) ,partial
  • 貨號：
    CSB-BP009747DIL
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Danio rerio G-protein coupled receptor 126(gpr126) ,partial
  • 貨號：
    CSB-MP009747DIL
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    adgrg6; gpr126Adhesion G-protein coupled receptor G6; G-protein coupled receptor 126) [Cleaved into: ADGRG6 N-terminal fragment; ADGRG6-NTF); ADGRG6 C-terminal fragment; ADGRG6-CTF)]
  • 種屬：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Plays also a role in inner ear development.; Plays an important role in heart development. Necessary and sufficient for axon sorting by Schwann cells independently of the ADGRG6-CTF.
  • 基因功能參考文獻：
    1. A new zebrafish mutation that truncates Gpr126 disrupted development of peripheral nerves and the inner ear. PMID: 25118328
    2. GPR126 modulates both physiological and pathological angiogenesis through VEGF signaling PMID: 25217645
    3. a model in which the NTF of Gpr126, in contrast to the C-terminal fragment, plays an important role in heart development. PMID: 24082093
    4. Gpr126 acts through a cAMP-mediated pathway to control the outgrowth and adhesion of canal projections in the zebrafish ear via the regulation of extracellular matrix gene expression. PMID: 24067352
    5. gpr126 mutant Schwann cells elaborate mature myelin sheaths and maintain krox20 expression for months, provided that the early signaling defect is bypassed by transient elevation of cAMP. PMID: 23804499
    6. study found that Gpr126 is required autonomously in Schwann cells for myelination; propose that Gpr126 drives the differentiation of promyelinating Schwann cells by elevating cAMP levels, thereby triggering Oct6 expression and myelination PMID: 19745155

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily
  • 組織特異性：
    Expressed in Schwann cells of the posterior lateral line nerve and in brain.
  • 數據庫鏈接：


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