在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Cricetulus griseus Poly [ADP-ribose] polymerase 1 (PARP1), partial

Recombinant Cricetulus griseus Poly [ADP-ribose] polymerase 1 (PARP1), partial

  • 中文名稱：
    Recombinant Cricetulus griseus Poly [ADP-ribose] polymerase 1(PARP1) ,partial
  • 貨號：
    CSB-YP874170DXU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Cricetulus griseus Poly [ADP-ribose] polymerase 1(PARP1) ,partial
  • 貨號：
    CSB-EP874170DXU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Cricetulus griseus Poly [ADP-ribose] polymerase 1(PARP1) ,partial
  • 貨號：
    CSB-EP874170DXU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Cricetulus griseus Poly [ADP-ribose] polymerase 1(PARP1) ,partial
  • 貨號：
    CSB-BP874170DXU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Cricetulus griseus Poly [ADP-ribose] polymerase 1(PARP1) ,partial
  • 貨號：
    CSB-MP874170DXU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    PARP1; ADPRT; Poly [ADP-ribose] polymerase 1; PARP-1; EC 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; DNA ADP-ribosyltransferase PARP1; EC 2.4.2.-; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1; EC 2.4.2.-
  • 種屬：
    Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate, serine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1. Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 conferring serine specificity by completing the PARP1 active site. Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1. PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation. Mediates the poly(ADP-ribosyl)ation of a number of proteins, including itself, APLF and CHFR. In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Acts as a regulator of transcription: positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and EEF1A1. Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming.
  • 基因功能參考文獻：
    1. findings show that PARP-End-Joining(EJ)is solely used when Ku is deficient but not when either DNA-PKcs or Xrcc4 is lacking; PARP-EJ may work on double strand breaks ends at high fidelity manner, as evident from the unchanged efficiency upon blocking end resection PMID: 24210699
  • 亞細胞定位：
    Nucleus. Nucleus, nucleolus. Chromosome.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产精品久久久久久人妻精品动漫| 动漫精品专区一区二区三区| 国精产品蘑菇一区一区有限| 午夜天堂一区人妻| 国产欧美综合一区二区三区| 特级a欧美做爰片三人交| 中文字幕乱码免费专区| 欧美成人国产精品高潮| 中文在线а√天堂| 国产薄丝脚交视频在线观看| 国产亚洲欧美日韩在线观看一区 | 日日摸天天摸人人看| 色婷婷五月综合色啪网| 又粗又硬又大又爽免费视频播放| 亚洲国产午夜精品理论片| 120秒试看无码体验区| 加勒比色综合久久久久久久久 | 久久777国产线看观看精品| 午夜福利视频极品国产83| 亚洲中国精品精华液| 无码精品人妻一区二区三区影院 | 欧美亚洲色综久久精品国产| 人妻无码一区二区三区tv| 亚洲午夜成人精品无码| 色婷婷亚洲一区二区三区| 欧美gv在线观看| 婷婷色香五月综合缴缴情| 爱久久av一区二区三区| 色综合欧美在线视频区| 亚洲美女国产精品久久久久久久久| 无码精品一区二区三区免费视频| 国产丝袜美女一区二区三区| 两个人日本www免费版| 内谢少妇xxxxx8老少交| 国产成人片无码视频在线观看| 中文在线а√在线| 无码中文字幕波多野结衣| 日韩成人大屁股内射喷水 | 国产免费福利在线视频| 8888四色奇米在线观看| 日本特黄特色特爽大片|