Recombinant Conus striolatus Mu-conotoxin SxIIIA

中文名稱：

Recombinant Conus striolatus Mu-conotoxin SxIIIA
貨號：

CSB-YP317494CPH
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Conus striolatus Mu-conotoxin SxIIIA
貨號：

CSB-EP317494CPH
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Conus striolatus Mu-conotoxin SxIIIA
貨號：

CSB-EP317494CPH-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Conus striolatus Mu-conotoxin SxIIIA
貨號：

CSB-BP317494CPH
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Conus striolatus Mu-conotoxin SxIIIA
貨號：

CSB-MP317494CPH
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

N/A
Uniprot No.：

P0C8V2
別名：

; Mu-conotoxin SxIIIA
種屬：

Conus striolatus (Cone)
蛋白長度：

Cytoplasmic domain
表達區域：

1-22
氨基酸序列

RCCTGKKGSC SGRACKNLKC CA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin potently blocks rNav1.4/SCN4A (IC(50)= 7 nM). It also moderately blocks rNav1.1/SCN1A (IC(50)=370 nM), rNav1.2/SCN2A (IC(50)=1 uM), and mNav1.6/SCN6A (IC(50)=570 nM). It is noteworthy that coexpression of subunits beta-2 or beta-4 (but not beta-1 or beta-3) decrease by about 16-fold the binding potency of the toxin to rNav1.6, since these subunits (thanks to their extracellular domain) covalently bind to the key cysteine of the channel, thus preventing the covalent binding of the toxin. It is also noteworthy that the toxin is 50-fold more potent on mouse Nav1.6 than on rat Nav1.6. In vivo, when injected intraperitoneally or subcutaneously in mice, causes motor impairment, paralysis and death.
亞細胞定位：

Secreted.
蛋白家族：

Conotoxin M superfamily
組織特異性：

Expressed by the venom duct.