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  4. Recombinant Chilobrachys jingzhao Kappa-theraphotoxin-Cj1a

Recombinant Chilobrachys jingzhao Kappa-theraphotoxin-Cj1a

  • 中文名稱：
    Recombinant Chilobrachys jingzhao Kappa-theraphotoxin-Cj1a
  • 貨號：
    CSB-YP543486DRU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Chilobrachys jingzhao Kappa-theraphotoxin-Cj1a
  • 貨號：
    CSB-EP543486DRU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Chilobrachys jingzhao Kappa-theraphotoxin-Cj1a
  • 貨號：
    CSB-EP543486DRU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Chilobrachys jingzhao Kappa-theraphotoxin-Cj1a
  • 貨號：
    CSB-BP543486DRU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Chilobrachys jingzhao Kappa-theraphotoxin-Cj1a
  • 貨號：
    CSB-MP543486DRU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 別名：
    Kappa-theraphotoxin-Cg1a 5; Kappa-TRTX-Cg1a; Jingzhaotoxin-11.5; JZTX-11.5; Jingzhaotoxin-XI.5; JZTX-XI.5; Peptide F4-13.64
  • 種屬：
    Chilobrachys jingzhao (Chinese earth tiger tarantula) (Chilobrachys guangxiensis)
  • 蛋白長度：
    Cytoplasmic domain
  • 表達區域：
    51-84
  • 氨基酸序列
    ECRKMFGGCS VDSDCCAHLG CKPTLKYCAW DGTF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    This toxin acts as a voltage-dependent gating-modifier. It inhibits the sodium conductance (IC(50)=124 nM) and slows the fast inactivation (EC(50)=1180 nM) of Nav1.5/SCN5A. It significantly shifts the activation to more depolarized voltages and decreases the deactivation of Nav1.5 currents upon extreme depolarization, but only slightly affects voltage-dependence of steady-state inactivation. In addition, this toxin causes an approximately five-fold decrease in the rate of recovery from inactivation and an approximately 1.9-fold reduction in the closed-state inactivation rate. This toxin integrates the functions of site 3 toxins (alpha-scorpion toxins) with site 4 toxins (beta-scorpion and spider toxins) by targeting multiple sites on Nav1.5. Also shows inhibition of voltage-gated potassium channels (5 uM completely inhibits Kv2.1/KCNB1, whereas 5 uM moderately inhibits Kv4.2/KCND2 Kv4.1/KCND1 channels).
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Huwentoxin-1 family, Jztx-11 subfamily
  • 組織特異性：
    Expressed by the venom gland.


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