在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Chicken Neuronal PAS domain-containing protein 2 (NPAS2), partial

  • 中文名稱:
    雞NPAS2重組蛋白
  • 貨號:
    CSB-YP717003CH
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    雞NPAS2重組蛋白
  • 貨號:
    CSB-EP717003CH
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    雞NPAS2重組蛋白
  • 貨號:
    CSB-EP717003CH-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    雞NPAS2重組蛋白
  • 貨號:
    CSB-BP717003CH
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    雞NPAS2重組蛋白
  • 貨號:
    CSB-MP717003CH
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    NPAS2
  • Uniprot No.:
  • 別名:
    NPAS2; MOP4; Neuronal PAS domain-containing protein 2; Neuronal PAS2; Member of PAS protein 4; MOP4
  • 種屬:
    Gallus gallus (Chicken)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. NPAS2 positively regulates the circadian expression of AANAT in the retinal photoreceptor cells.
  • 基因功能參考文獻:
    1. CLOCK plays the predominant role in the chicken photoreceptor circadian clockwork mechanism, including the regulation of NPAS2 expression PMID: 20345751
  • 亞細胞定位:
    Nucleus.
  • 組織特異性:
    Expressed in the retinal photoreceptor cells (at protein level). Expressed in the pineal gland and retina.
  • 數據庫鏈接:


主站蜘蛛池模板: 成人无码视频| 荫蒂添的好舒服视频囗交| 欧美性xxxx极品少妇| 国产又色又爽又黄的在线观看视频| 欧美成人精品高清在线播放| 国产福利日本一区二区三区| 女人与牲口性恔配视频免费| 国产成人a无码短视频| 婷婷射精av这里只有精品| 伊伊人成亚洲综合人网7777| 艳妇臀荡乳欲伦69调教视频| 亚洲精品综合一区二区三区在线| 99久久国产综合精品女图图等你| 奇米影视7777狠狠狠狠影视 | 大色综合色综合网站| 国产精品天干天干有线观看| 国产成人综合欧美精品久久| 成 人 黄 色 大片| 日韩免费无码成人久久久久久片| 精品国偷自产在线视频| 国产亚洲精品一区二区三区| 亚洲色婷婷六月亚洲婷婷6月| 人妻系列av无码专区| 国产69精品久久久久孕妇| 久久久久无码精品国产| 国产精品爽爽久久久久久蜜臀| 精品一区二区三区在线观看视频| 最新国产精品精品视频| 欧美亚洲日韩不卡在线在线观看| 高清不卡一区二区三区| 国产免国产免‘费| 成年轻人电影免费无码| 亚洲 制服 丝袜 无码 在线| 欧美拍拍视频免费大全| 爆乳熟妇一区二区三区| av无码一区二区二三区1区6区| 国产午夜福利伦理300| 精品少妇无码av无码专区 | 中出内射颜射骚妇| 在线高清亚洲精品二区| 亚洲精品午夜一区人人爽|