在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Chicken BDNF/NT-3 growth factors receptor (NTRK2), partial

  • 中文名稱:
    雞NTRK2重組蛋白
  • 貨號:
    CSB-YP845939CH
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    雞NTRK2重組蛋白
  • 貨號:
    CSB-EP845939CH
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    雞NTRK2重組蛋白
  • 貨號:
    CSB-EP845939CH-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    雞NTRK2重組蛋白
  • 貨號:
    CSB-BP845939CH
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    雞NTRK2重組蛋白
  • 貨號:
    CSB-MP845939CH
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    NTRK2; TRKB; BDNF/NT-3 growth factors receptor; EC 2.7.10.1; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Trk-B
  • 種屬:
    Gallus gallus (Chicken)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
  • 基因功能參考文獻:
    1. BDNF released by preganglionic axons acts chemotactically on TrkB-positive sympathetic neurons, to pattern the developing peripheral nervous system. PMID: 26404565
    2. Cessation of TrkB expression is essential for dendrite retraction and functional maturation of nucleus magnocellularis neurons. PMID: 23035107
    3. These results suggest that BDNF promotes the induction of imprinting through TrkB exclusively during the critical period. PMID: 23094873
    4. Activation of BDNF/TrkB signaling in the intermediate medial hyperpallium apicale is not involved in memory acquisition in filial imprinting in newly hatched chicks. PMID: 22015740
    5. findings demonstrate roles for BDNF-induced, trk-dependent signaling in ciliary ganglion neurons, both in regulating expression of alpha7-nAChRs and in enhancing transmission at alpha3*-nAChR-mediated synapses PMID: 15128848
    6. elevated BDNF expression above basal levels and signaling through TrkB in sympathoblasts may be a mechanism that contributes to the onset of neuroblastoma PMID: 17309801
    7. The ephrinA/TrkB Interaction is neurotrophin induced and specifically augments the PI-3 kinase/Akt pathway generally known to be involved in the promotion of branching. PMID: 19036963

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region. Cell junction, synapse, postsynaptic density.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
  • 組織特異性:
    Detected in embryonic brain and orsal root ganglia.
  • 數據庫鏈接:


主站蜘蛛池模板: 国产av麻豆mag剧集| 无码精品a∨在线观看中文| 麻豆一区二区99久久久久| 国产亚洲精品久久久网站好莱| 强开小婷嫩苞又嫩又紧视频韩国 | 乱码视频午夜间在线观看| 亚洲超清无码制服丝袜无广告| 久青草久青草视频在线观看| 狠狠噜天天噜日日噜| 中文字幕人成乱码熟女app| 亚洲综合av色婷婷| 992tv精品视频tv在线观看| 日本xxx在线观看免费播放| 精品久久久无码人妻中文字幕| 亚洲精品久久久久久| 亚洲美女高清无水av| 天天鲁在视频在线观看| av无码一区二区三区| 亚洲妇熟xxxx妇色黄| 日本十八禁黄无遮禁视频免费| 国产男生夜间福利免费网站| 中文字幕人妻丝袜二区| 亚洲乱亚洲乱妇小说网| 亚洲熟妇久久国内精品| 情侣激情18内射骚话国产 | 少妇无码精油按摩专区| 久久99国产精品久久99| 男女猛烈无遮挡免费视频| 天干夜啦天干天干国产免费| 中文亚洲无线码49vv| 无码日韩精品一区二区免费暖暖| 5个黑人躁我一个视频| 日本少妇高潮喷水视频| 亚洲国产精品成人综合色| 亚洲の无码国产の无码步美| 丁香色婷婷国产精品视频| 精品国产乱码久久久久乱码| 久久天天躁狠狠躁夜夜2019| 无码专区人妻系列日韩精品少妇| 国产又色又爽又黄好看的视频| 日本少妇内射视频播放舔|