在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Bovine viral diarrhea virus Genome polyprotein, partial

  • 中文名稱:
    Recombinant Bovine viral diarrhea virus Genome polyprotein ,partial
  • 貨號:
    CSB-YP324843BKW1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Bovine viral diarrhea virus Genome polyprotein ,partial
  • 貨號:
    CSB-EP324843BKW1
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Bovine viral diarrhea virus Genome polyprotein ,partial
  • 貨號:
    CSB-EP324843BKW1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Bovine viral diarrhea virus Genome polyprotein ,partial
  • 貨號:
    CSB-BP324843BKW1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Bovine viral diarrhea virus Genome polyprotein ,partial
  • 貨號:
    CSB-MP324843BKW1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    N/A
  • Uniprot No.:
  • 別名:
    Genome polyprotein
  • 種屬:
    Bovine viral diarrhea virus (isolate NADL) (BVDV) (Mucosal disease virus)
  • 蛋白長度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Leader cysteine autoprotease that cleaves itself from the nascent polyprotein during translation of the viral mRNA. Once released, plays a role in the inhibition of host innate immune response by interacting with host IRF3 and inducing its proteasomal degradation.; Packages viral RNA to form a viral nucleocapsid and thereby protects viral RNA. Plays also a role in transcription regulation. Protects the incoming virus against IFN-induced effectors.; Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans.; E1 and/or E2 are probably responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis.; E1 and/or E2 are probably responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis.; Plays an essential role in the virus replication cycle by acting as a viroporin. Forms ion conductive pores, which alters the cell permeability allowing the transport of ions and other small molecules. Forms a leader sequence to properly orient NS2 in the membrane.; Uncleaved NS2-3 is required for production of infectious virus.; Plays a role in the regulation of viral RNA replication.; Multifunctional protein that contains an N-terminal protease and a C-terminal helicase, playing essential roles in viral polyprotein processing and viral genome replication. The chymotrypsin-like serine protease activity utilizes NS4A as an essential cofactor and catalyzes the cleavage of the polyprotein leading to the release of NS4A, NS4B, NS5A, and NS5B. Interacts with NS5B to enhance RNA-dependent RNA polymerase activity.; Acts as a cofactor for the NS3 protease activity.; Induces a specific membrane alteration that serves as a scaffold for the virus replication complex.; Replicates the viral (+) and (-) genome.
  • 基因功能參考文獻:
    1. Bovine viral diarrhea virus 1 infection of monocyte-derived dendritic cells was prevented by incubating the virus with anti-viral E2 antibodies or by pretreating the cells with recombinant E2 protein before virus contact, suggesting that the virus infects monocyte-derived dendritic cells through an E2-mediated mechanism. PMID: 27529119
    2. E2 acts as a host complement regulatory protein. PMID: 27038454
    3. The viral N-terminal protease interact with host proteins and are components of the ribonucleoprotein complex. PMID: 24965446
    4. E2 glycoproteins of both BVDV type 1 and type2 exhibit a comparable antigenic structure, but with type specific epitopes PMID: 23838147
    5. These findings reveal the existence of an alternative -1/+2 ORF in the N(pro)(1-19) region during the replication of bovine viral diarrhea virus and open a new avenue to understand the life cycle and pathogenesis of pestiviruses. PMID: 22079882
    6. The NS2 and NS3 are not essential for virion morphogenesis. PMID: 22031952
    7. The minimal residues of NIBP that interact with NS5A of bovine viral diarrhea virus were mapped as aa 597-623. PMID: 20444997
    8. BVDV NS3/NS3Delta50 induces apoptosis initiated by caspase-8 activation and subsequent cytochrome c release-dependent caspase-9 activation. PMID: 15720974
    9. These findings suggest dual mechanisms of pestivirus superinfection exclusion, one at the level of viral entry that requires viral glycoprotein E2 and a second at the level of viral RNA replication. PMID: 15731218
    10. the results of this study demonstrate a surprising flexibility within the palm region of a plus-strand RNA virus RNA dependent RNA polymerase, resulting in viral attenuation in vitro. PMID: 17098978
    11. These results suggest that the NS2-3 protein of ncp bovine viral diarrhea virus 1 is cleaved in vivo. PMID: 18557898
    12. This study demonstrated that authentic, enzymically active E(rns) produced in mammalian cells prevented a dsRNA-induced IFN response when present in the supernatant of bovine cells. [E(rns)] PMID: 18796719
    13. These experiments showed that a Y1338H substitution at residue 193 of NS2 resulted in the temperaturedependent attenuation of cytopathogenicity despite high levels of infectious virus production. PMID: 19776121
    14. These data suggest that the NS3/4A protein is responsible for regulating the levels of cellular apoptosis and provide new insights regarding the viral elements associated with cytopathogenic biotype pathogenesis. PMID: 19793904

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Capsid protein C]: Virion.; [E(rns) glycoprotein]: Host membrane; Peripheral membrane protein. Virion membrane; Peripheral membrane protein.; [Envelope glycoprotein E2]: Host cell surface. Virion membrane.; [Cysteine protease NS2]: Host membrane; Multi-pass membrane protein.; [Serine protease NS3]: Host cytoplasm.; [Non-structural protein 4B]: Host cytoplasm.; [Non-structural protein 5A]: Host cytoplasm.
  • 蛋白家族:
    Pestivirus polyprotein family
  • 數(shù)據(jù)庫鏈接:

    KEGG: vg:1489735



主站蜘蛛池模板: 天天摸天天做天天爽水多| 国产美女裸体丝袜喷水视频| 永久久久免费人妻精品| 日韩成人av无码一区二区三区| 欧美老熟妇乱子| 亚洲人成网站18禁止无码| 国产内射老熟女aaaa∵| 日本高清www午色夜在线视频| 香蕉久久国产超碰青草| 99精品免视看| 极品尤物一区二区三区| 网友自拍区视频精品| 亚洲精品国产自在久久| 日本xxxxx片免费观看喷水| 97精品国产手机| 蜜臀av午夜一区二区三区| 天堂在线www中文| 国产精品系列无码专区| 国产中文字字幕乱码无限| 日本特黄特色特爽大片| 亚洲中文字幕久久精品无码va| 18禁精品久久久国产精品久久久| 国产福利一区二区三区在线视频 | 亚洲欧美日韩综合一区二区| 在线看片免费人成视频福利 | 久久99亚洲网美利坚合众国| 亚洲国产精品成人综合色| 国产吃奶在线观看| a片免费视频在线观看| 国产亚洲精品久久久久久打不开| 国色天香精品一卡2卡3卡4| 少妇又色又紧又爽又刺激视频| 成人性能视频在线| 99er国产这里只有精品视频免费 | 少妇做爰又色又紧夜视频| 成人亚洲欧美丁香在线观看| 夜夜爽日日澡人人添| 性按摩xxxx在线观看| 亚洲伊人色综合www962| 羞羞影院午夜男女爽爽免费| 97人人模人人爽人人喊网|