在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Bovine cGMP-gated cation channel alpha-1 (CNGA1), partial

  • 中文名稱:
    Recombinant Bovine cGMP-gated cation channel alpha-1(CNGA1) ,partial
  • 貨號:
    CSB-YP005642BO1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Bovine cGMP-gated cation channel alpha-1(CNGA1) ,partial
  • 貨號:
    CSB-EP005642BO1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Bovine cGMP-gated cation channel alpha-1(CNGA1) ,partial
  • 貨號:
    CSB-EP005642BO1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Bovine cGMP-gated cation channel alpha-1(CNGA1) ,partial
  • 貨號:
    CSB-BP005642BO1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Bovine cGMP-gated cation channel alpha-1(CNGA1) ,partial
  • 貨號:
    CSB-MP005642BO1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    CNGA1; CNCG; CNCG1; cGMP-gated cation channel alpha-1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
  • 種屬:
    Bos taurus (Bovine)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.
  • 基因功能參考文獻:
    1. These results suggest that restraining the A' helix to the plasma membrane potentiates CNGA1 channel opening. PMID: 26969165
    2. Conformation changes of CNGA1 associated with its gating function are reported. PMID: 25963832
    3. Data show that when Pro365 is replaced with a threonine in cyclic nucleotide gated channel alpha 1 (CNGA1), cesium Cs+ permeation is nearly abolished. PMID: 26100907
    4. Stabilizing the C-helix of intact CNGA1 channels by metal binding to a pair of histidines promoted channel opening. PMID: 23525108
    5. A ring of threonines in the inner vestibule of the pore of CNGA1 channels constitutes a binding site for permeating ions PMID: 22869010
    6. Three CNGA1 subunits and a single CNGB1 subunit form the rod cyclic nucleotide-gated ion channels. PMID: 21878911
    7. Existence of a strong coupling between the upper portion of the S6 helix provides a simple molecular mechanism for CNGA1 gating. PMID: 19289572
    8. The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry PMID: 12432397
    9. Data suggest that the native rod cyclic nucleotide-gated (CNG) channel is a tetramer composed of three A1 and one B1 subunit. PMID: 12467591
    10. Data show that the cyclic nucleotide-gated (CNG) channel contains three CNGA1 subunits and only one CNGB1 subunit. PMID: 12467592
    11. Structural models of the tetrameric cyclic nucleotide gated channel alpha 1 from bovine rod is presented. PMID: 15792804
    12. In CNGA1 channels, pore gating is involved in the rate-limiting reactions determining the activation time course in the sequence of events between cGMP binding and pore opening. PMID: 16473910
    13. These observations suggest that these effects are mediated by the formation of a disulfide bond (S-S) between F380C and the endogenous Cys-314 in the S5 segment. PMID: 16513780
    14. analyze in detail the molecular mechanisms underlying Cd2+ inhibition and longer cross-linkers in mutant CNGA1 channels PMID: 19132361
    15. detailed analysis of conformational changes of the S6 domain and C-linker during gating of CNGA1 channels PMID: 19488745

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA1 subfamily
  • 組織特異性:
    Expressed in the retina, in rod cells (at protein level).
  • 數據庫鏈接:

    KEGG: bta:281700

    STRING: 9913.ENSBTAP00000002853

    UniGene: Bt.53



主站蜘蛛池模板: 日本爽爽爽爽爽爽在线观看免| 成熟了的熟妇毛茸茸| 国产精品免费久久久久影院| 国产精品无码专区av在线播放| 国产成人福利美女观看视频| 国产成人综合95精品视频| 国产精品午夜爆乳美女视频| 99久在线国内在线播放免费观看 | 国精产品一区一区三区免费视频| 熟妇人妻一区二区三区四区| 无尺码精品产品日韩| 亚洲视频日本有码中文| 亚洲日韩欧美一区久久久久我| а天堂中文官网| 天天综合爱天天综合色| 激情欧美成人久久综合| 中文字幕人成乱码熟女免费| 亚洲乱亚洲乱妇| 亚洲国产美国国产综合一区| 国产成人av在线影院无毒| 天天爽夜夜爱| 国产精品久久久久久影视| 饥渴少妇做私密保健视频| 国语自产视频在线| 特黄aaaaaaa片免费视频| 色综合中文综合网| 硬了进去湿好大娇喘视频| 欧美性猛交xxxxx按摩欧美| 97久久草草超级碰碰碰| julia无码中文字幕一区| 色猫咪av在线观看| 中文字幕亚洲综合久久综合| 免费的av网站手机版| 大肉大捧一进一出好爽视频| 国产99久久九九精品无码| 熟妇丰满大屁股在线播放| 久久精品99久久香蕉国产| 无码人妻aⅴ一区二区三区| 成a人片亚洲日本久久| 久久久774这里只有精品17| 产精品视频在线观看免费|