在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Bovine Serine/threonine-protein kinase PAK 1 (PAK1), partial

  • 中文名稱:
    牛PAK1重組蛋白
  • 貨號:
    CSB-YP600957BO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    牛PAK1重組蛋白
  • 貨號:
    CSB-EP600957BO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    牛PAK1重組蛋白
  • 貨號:
    CSB-EP600957BO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    牛PAK1重組蛋白
  • 貨號:
    CSB-BP600957BO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    牛PAK1重組蛋白
  • 貨號:
    CSB-MP600957BO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    PAK1Serine/threonine-protein kinase PAK 1; EC 2.7.11.1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK
  • 種屬:
    Bos taurus (Bovine)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. In podocytes, promotes NR3C2 nuclear localization. Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation. Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion. In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC). Along with GIT1, positively regulates microtubule nucleation during interphase.
  • 亞細胞定位:
    Cytoplasm. Cell junction, focal adhesion. Cell projection, lamellipodium. Cell membrane. Cell projection, ruffle membrane. Cell projection, invadopodium. Nucleus, nucleoplasm. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 在线高清理伦片a| 午夜免费啪视频在线观看区| 99久e在线精品视频在线| 日产精品卡二卡三卡四卡区满十八 | 日本www网站色情乱码| 国产欧美va天堂在线观看视频下载| 国产人妖xxxx做受视频| 韩国精品福利一区二区三区| 伊在人天堂亚洲香蕉精品区| 日日摸夜夜摸狠狠摸婷婷| 亚洲精品伊人久久久大香| 国产边打电话边被躁视频| 欧美成人精品第一区二区三区| 六月丁香婷婷色狠狠久久| 日本无码人妻精品一区二区蜜桃| 亚洲人成网站18禁止| mm1313亚洲国产精品无码试看| 2024av天堂手机在线观看| 无码少妇一区二区三区芒果| 久久久www成人免费看片| 亚洲国产成人久久一区| 天天躁日日躁aaaaxxxx| 久久精品一区二区三区四区| 免费无码一区二区三区a片| 久久人妻xunleige无码| 久久不见久久见www电影免费| 国产精品久久一区二区三区| 中日韩高清无专码区2021| 青青草国产精品欧美成人| 久久精品中文字幕第一页| а天堂中文最新一区二区三区| 热re99久久精品国产66热| 任你干视频精品播放| 精产国品一二三产品麻豆| 一本一道av无码中文字幕﹣百度| 女人高潮流白浆视频| 午夜成人爽爽爽视频在线观看| 成人伊人亚洲人综合网| 亚洲人成色77777在线观看| 中文字幕aⅴ人妻一区二区| 精品香蕉久久久午夜福利|