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  4. Recombinant Bovine Pigment epithelium-derived factor (SERPINF1)

Recombinant Bovine Pigment epithelium-derived factor (SERPINF1)

  • 中文名稱：
    牛SERPINF1重組蛋白
  • 貨號：
    CSB-YP846450BO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    牛SERPINF1重組蛋白
  • 貨號：
    CSB-EP846450BO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    牛SERPINF1重組蛋白
  • 貨號：
    CSB-BP846450BO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    牛SERPINF1重組蛋白
  • 貨號：
    CSB-MP846450BO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    SERPINF1; PEDFPigment epithelium-derived factor; PEDF; Serpin F1
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    full length protein
  • 表達區域：
    21-416
  • 氨基酸序列
    NAGQEAGSLT PESTGAPVEE EDPFFKVPVN KLAAAVSNFG YDLYRVRSGE SPTANVLLSP LSVATALSAL SLGAEQRTES NIHRALYYDL ISNPDIHGTY KDLLASVTAP QKNLKSASRI IFERKLRIKA SFIPPLEKSY GTRPRILTGN SRVDLQEINN WVQAQMKGKV ARSTREMPSE ISIFLLGVAY FKGQWVTKFD SRKTSLEDFY LDEERTVKVP MMSDPQAVLR YGLDSDLNCK IAQLPLTGST SIIFFLPQKV TQNLTLIEES LTSEFIHDID RELKTVQAVL TIPKLKLSYE GELTKSVQEL KLQSLFDAPD FSKITGKPIK LTQVEHRVGF EWNEDGAGTN SSPGVQPARL TFPLDYHLNQ PFIFVLRDTD TGALLFIGKI LDPRGT
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
  • 基因功能參考文獻：
    1. PEDF inhibits key steps in the angiogenic response of retinal capillary endothelial cells, including cell proliferation and vascular tubule formation. Gene expression of PEDF is negatively regulated by glucose, insulin (via mTOR) and VEGF. PMID: 20219495
    2. Results suggest that leptin might elicit angiogenesis through vascular endothelial growth factor induction as well as pigment epithelium-derived factor suppression in pericytes. PMID: 12779248
    3. PEDF promotes growth of pericytes through autocrine production of PDGFB. PMID: 15896354
    4. PEDF and VEGFR-1 have roles in the negative regulation of angiogenesis PMID: 16339148
  • 亞細胞定位：
    Secreted. Melanosome.
  • 蛋白家族：
    Serpin family
  • 組織特異性：
    Retinal pigment epithelial cells. Located in the interphotoreceptor matrix (IPM) which is between the retinal pigment epithelium and the neural retina.
  • 數據庫鏈接：


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