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  4. Recombinant Bovine Peroxisome proliferator-activated receptor gamma (PPARG), partial

Recombinant Bovine Peroxisome proliferator-activated receptor gamma (PPARG), partial

  • 中文名稱：
    牛PPARG重組蛋白
  • 貨號：
    CSB-YP018424BO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    牛PPARG重組蛋白
  • 貨號：
    CSB-EP018424BO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    牛PPARG重組蛋白
  • 貨號：
    CSB-EP018424BO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    牛PPARG重組蛋白
  • 貨號：
    CSB-BP018424BO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    牛PPARG重組蛋白
  • 貨號：
    CSB-MP018424BO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    PPARG; NR1C3; Peroxisome proliferator-activated receptor gamma; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.
  • 基因功能參考文獻：
    1. Three novel SNPs of the bovine PPARgamma gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C > G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C > T) and SNP3 (AC_000179.1 g.57431994 T > C) in exon 7. PMID: 28481711
    2. These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB activation through a mechanism partly dependent on PPARgamma activation. PMID: 28095338
    3. PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells. PMID: 27287918
    4. An Asp7Gly substitution in PPARG is associated with adiposity. PMID: 24466299
    5. upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age PMID: 24200561
    6. Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 gene expression in adipocytes. PMID: 22748806
    7. A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated. PMID: 22930427
    8. study demonstrates the co-expression of DLX3, PPARG and SP1 in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation PMID: 21937107
    9. Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined. PMID: 20306301
    10. oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells PMID: 20302927
    11. The effects of dietary fat components on the expression of PPAR-gamma AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported. PMID: 20154154
    12. Intramammary infection elicited a strong transcriptomic response, leading to potent activation of pro-inflammatory pathways that were associated with a marked inhibition of lipid synthesis, stress-activated kinase signaling cascades, and PPAR signaling. PMID: 19925655
    13. PPARgamma1 has bifunctional properties in the regulation of KDR gene expression mediated via interaction with both Sp1 and Sp3 PMID: 15111490
    14. There is evidence of cotranscription and intergenic splicing events between the PPARG gene and the neighboring gene TSEN2 in cattle. Two types of chimeric transcripts are observed. PMID: 16595010

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 組織特異性：
    Highest expression in adipose tissue. Lower in spleen and lung. Also detected in ovary, mammary gland and small intestine.
  • 數據庫鏈接：


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