在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Bovine Endothelin-1 (EDN1)

Recombinant Bovine Endothelin-1 (EDN1)

  • 中文名稱：
    牛EDN1重組蛋白
  • 貨號：
    CSB-YP007400BO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    牛EDN1重組蛋白
  • 貨號：
    CSB-EP007400BO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    牛EDN1重組蛋白
  • 貨號：
    CSB-EP007400BO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    牛EDN1重組蛋白
  • 貨號：
    CSB-BP007400BO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    牛EDN1重組蛋白
  • 貨號：
    CSB-MP007400BO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    EDN1Endothelin-1; ET-1; Preproendothelin-1; PPET1) [Cleaved into: Big endothelin-1]
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    Cytoplasmic domain
  • 表達區域：
    53-73
  • 氨基酸序列
    CSCSSLMD KECVYFCHLD IIW
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells.
  • 基因功能參考文獻：
    1. EDN-1 may be involved in the protection of sperm from phagocytosis by polymorphonuclear neutrophils in the bovine oviduct, supporting sperm survival until fertilization PMID: 26781611
    2. Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2, EDN3) and EDN-converting enzymes (ECE1, ECE2) are expressed in epithelial cells; EDN receptors (EDNRA, EDNRB) are present in smooth-muscle. Expression of EDN1, EDN2, and ECE2 is highest on day of ovulation. EDN/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows. PMID: 25370848
    3. results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase-PKCalpha-p(38)MAPK and NFkappaB-MT1MMP signaling pathways along with a marked decrease in TIMP-2 expression in the cells PMID: 26910780
    4. We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 activity in the cell membrane. PMID: 25399298
    5. Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy. PMID: 22921266
    6. Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells. PMID: 12826225
    7. Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels PMID: 14609525
    8. prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis PMID: 15269098
    9. LOX-1 and CD40 synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells. PMID: 15838273
    10. Elevated local expression of ET-1 and Ednra/Ednrb during the peri-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport. PMID: 15838292
    11. Suggest that the activation of a local positive feedback mechanism in the corpus luteum among ET-1, Ang II and PGF2alpha might play a functional role in the paracrine modulation of luteolytic cascade. PMID: 15838293
    12. The combined metabolic burden of homocysteine and high glucose stimulates ET-1 synthesis in bovine aortic endothelial cells via a mechanism dependent on the production of mitochondrial ROS, but may not be generalisable to all types of endothelial cells. PMID: 16410680
    13. hypoxia and endothelin-1 have roles in mediating vasa vasorum neovascularization with pulmonary artery adventitial fibroblasts PMID: 16723696
    14. The present study thus showed that neither leptin nor resistin affects the expression of endothelin-1 or adrenomedullin in bovine brain microvascular endothelial cells. PMID: 16940707
    15. Intraluteal OXT may locally modulate secretion of vasoactive substances, particularly EDN1 and PGF(2alpha) within the corpus luteum. PMID: 17287495
    16. Endothelin may be associated with final maturation of follicles. PMID: 17380043
    17. Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion PMID: 18718910

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Endothelin/sarafotoxin family
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲精品国产一区二区在线观看| 强行交换配乱婬bd| 亚洲阿v天堂在线| 国语做受对白xxxxx在线| 在线人成免费视频69国产| 男人靠女人的免费视频| 强奷乱码中文字幕熟女一| 少妇愉情理伦片丰满丰满午夜| 一本久道久久综合久久爱| 国产69精品久久久久乱码韩国| 免费人成视频| 激情综合五月| 国产亚洲中文日本不卡二区| 国内精品自在自线视频| 成人性生交大免费看| 精品女同一区二区三区免费站| 午夜福利一区二区三区高清视频 | 国产免费内射又粗又爽密桃视频| 精品国产乱码久久久久久夜深人妻 | 日本精品αv中文字幕| 成 人 亚洲 综合天堂| 在线播放无码后入内射少妇| 四川丰满妇女毛片四川话| 亚洲欧美国产毛片在线| 中文字幕乱码一区二区三区免费| 国产亚洲精选美女久久久久| 中文字幕中文乱码www| 麻豆精品导航| 日本狂喷奶水在线播放212| 日本人妻精品免费视频| 蜜臀av无码精品人妻色欲| 亚洲爆乳www无码专区| 免费能直接看黄的视频| 国产在线精品一区二区三区| 精品人妻午夜一区二区三区四区| 亚洲精品国产av天美传媒| 秋霞国产精品一区二区| 精品国产污污免费网站入口| 亚洲精品成人a在线观看| 国产美女被遭高潮免费网站| 国产在线视频一区二区三区|