在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Bovine E3 ubiquitin-protein ligase RNF168 (RNF168), partial

Recombinant Bovine E3 ubiquitin-protein ligase RNF168 (RNF168), partial

  • 中文名稱：
    牛RNF168重組蛋白
  • 貨號：
    CSB-YP606591BO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    牛RNF168重組蛋白
  • 貨號：
    CSB-EP606591BO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    牛RNF168重組蛋白
  • 貨號：
    CSB-EP606591BO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    牛RNF168重組蛋白
  • 貨號：
    CSB-BP606591BO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    牛RNF168重組蛋白
  • 貨號：
    CSB-MP606591BO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RNF168
  • Uniprot No.：
  • 別名：
    RNF168; E3 ubiquitin-protein ligase RNF168; EC 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    RNF168 family
  • 數據庫鏈接：

    KEGG: bta:613812

    STRING: 9913.ENSBTAP00000017712

    UniGene: Bt.6014



主站蜘蛛池模板： 亚洲无线码免费| 国产高潮国产高潮久久久| 国产精品186在线观看在线播放| 精品久久久久久无码人妻蜜桃| 欧美人成视频在线视频| 午夜爽爽爽男女免费观看麻豆国产 | 久久九九有精品国产尤物| 国产露脸无套对白在线播放| 无码日本精品xxxxxxxxx| 成人av久久一区二区三区| 国内精品久久久久影院优| 久热国产精品视频一区二区三区 | 国产欧美va天堂在线电影| 亚洲无线码中文字幕在线| 国产欧美日韩va另类在线播放| 粗了大了 整进去好爽视频| 硬了进去湿好大娇喘视频 | 亚洲日本va午夜中文字幕一区| 久久午夜无码鲁丝片秋霞| 久久99久久99小草精品免视看| 日韩亚洲国产高清免费视频| 亚洲人妻av伦理| 亚洲 自拍 另类小说综合图区| 亚洲日韩穿丝袜在线推荐 | 中文字幕久久熟女人妻av免费| 国产精品成人久久久久久久| 玩肥熟老妇bbw视频| 亚洲.欧美.在线视频| 色偷偷色噜噜狠狠成人免费视频| 国产精品无码专区在线观看| 四虎影视无码永久免费| 18级成人毛片免费观看| 色爱无码av综合区| 好了av四色综合无码久久| 亚洲kkk4444在线观看| 国内老熟妇乱子伦视频| 亚 洲 视 频 高 清 无 码| 国产性猛交普通话对白| 人人澡人人澡人人看添av | 女人被男人桶30分钟无遮挡动态图| 人妻少妇无码中文幕久久|