在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Bovine E3 ubiquitin-protein ligase RNF168 (RNF168), partial

Recombinant Bovine E3 ubiquitin-protein ligase RNF168 (RNF168), partial

  • 中文名稱：
    牛RNF168重組蛋白
  • 貨號：
    CSB-YP606591BO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    牛RNF168重組蛋白
  • 貨號：
    CSB-EP606591BO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    牛RNF168重組蛋白
  • 貨號：
    CSB-EP606591BO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    牛RNF168重組蛋白
  • 貨號：
    CSB-BP606591BO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    牛RNF168重組蛋白
  • 貨號：
    CSB-MP606591BO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RNF168
  • Uniprot No.：
  • 別名：
    RNF168; E3 ubiquitin-protein ligase RNF168; EC 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    RNF168 family
  • 數據庫鏈接：

    KEGG: bta:613812

    STRING: 9913.ENSBTAP00000017712

    UniGene: Bt.6014



主站蜘蛛池模板： 在线人人车操人人看视频| 在线a亚洲视频播放在线观看| av午夜久久蜜桃传媒软件| 成 人色 网 站 欧美大片在线观看 | 一区二三区在线 | 中国| 国产成人免费永久在线平台| 亚洲精品久久久久久下一站| 成人无码男男gv在线观看网站| 色欲综合久久中文字幕网| 久久久亚洲一区二区三区| 国产内射合集颜射| 精品系列无码一区二区三区| 嫩草研究院久久久精品| 亚洲乱码国产乱码精品精| 精品无码av一区二区三区| 亚洲精品无码成人片久久| 国产午夜精品久久久久免费视| а天堂8中文最新版在线官网| 国产女人高潮嗷嗷嗷叫| 国内少妇偷人精品视频| 欧美日韩综合一区二区三区| 色偷一区国产精品| 无码免费无线观看在线视| 三级男人添奶爽爽爽视频| 国内露脸中年夫妇交换| 任你干视频精品播放| 久久精品青青草原伊人| 丰满人妻被黑人猛烈进入| 两个人日本www免费版| 成人免费无码不卡毛片| 激情爆乳一区二区三区| 中文字幕欧美人妻精品一区| 亚洲成a人v在线蜜臀| 男女猛烈无遮挡免费视频在线观看| 亚洲精品自在在线观看| 亚洲系列一区中文字幕| 色偷偷亚洲第一成人综合网址| 小说区 图片区色 综合区| 欧美亚洲偷图色综合| 亚洲欧洲日产国码无码网站| 国产精品视频|