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  4. Recombinant Bovine Coagulation factor XI (F11), partial

Recombinant Bovine Coagulation factor XI (F11), partial

  • 中文名稱：
    牛F11重組蛋白
  • 貨號：
    CSB-YP007916BO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    牛F11重組蛋白
  • 貨號：
    CSB-EP007916BO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    牛F11重組蛋白
  • 貨號：
    CSB-EP007916BO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    牛F11重組蛋白
  • 貨號：
    CSB-BP007916BO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    牛F11重組蛋白
  • 貨號：
    CSB-MP007916BO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    F11Coagulation factor XI; FXI; EC 3.4.21.27; Plasma thromboplastin antecedent; PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
  • 種屬：
    Bos taurus (Bovine)
  • 蛋白長度：
    partial
  • 表達區域：
    19-387
  • 氨基酸序列
    EC VTTLFQDACF KGGDITVAFA PNAKHCQIIC THHPRCLLFT FMTESSSEDP TKWYTCILKD SVTETLPMVN MTGAISGYSS KQCLHHISAC SKDMYVDLNM KGMNYNSSLA QSARECQQRC TDDTHCHFFT FATRHFPSIK DRNTCLLKNT QTGTPTSITK LHEVVSGFSL KSCGLSNLAC IRDIFPRTAF VDITIDTVMA PDPFVCRSIC THHPSCLFFT FLSEEWPTAS ERNLCLLKTS SSGLPSARFR KNRAFSGFSL QHCQHSVPVF CHSSFYRNTD FLGEELDIVD ADSHEACQKT CTNSIRCQFF TYSPSQESCN GGKGKCYLKL SANGSPTKIL HGTGSISGYT LRLCKMDNVC TTKIKTR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
  • 基因功能參考文獻：
    1. Sequence analysis of the bovine coagulation factor XI (F11) gene revealed an unusually high number of non-synonymous mutations. However, none of the mutations in the F11 gene were concordant with Bovine neonatal pancytopenia status. PMID: 21087874
    2. DNA was extracted and amplified from the bovine mummified fetuses, and the samples were successfully tested for Factor XI gene deficiency in the mummies. PMID: 15785014
    3. Insertion of 15 nucleotides in the F11 gene is the causative mutation for factor XI deficiency in Japanese black cattle. PMID: 16104386
    4. The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene PMID: 19433912
  • 相關疾病：
    Defects in F11 are the cause of factor XI deficiency in Japanese black cattle. It is a hereditary mild bleeding disorder with an autosomal recessive mode of inheritance.
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family, Plasma kallikrein subfamily
  • 數據庫鏈接：


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