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  4. Recombinant Bothrops alternatus Zinc metalloproteinase-disintegrin alternagin

Recombinant Bothrops alternatus Zinc metalloproteinase-disintegrin alternagin

  • 中文名稱：
    Recombinant Bothrops alternatus Zinc metalloproteinase-disintegrin alternagin
  • 貨號：
    CSB-YP315153BUS
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Bothrops alternatus Zinc metalloproteinase-disintegrin alternagin
  • 貨號：
    CSB-EP315153BUS
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Bothrops alternatus Zinc metalloproteinase-disintegrin alternagin
  • 貨號：
    CSB-EP315153BUS-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Bothrops alternatus Zinc metalloproteinase-disintegrin alternagin
  • 貨號：
    CSB-BP315153BUS
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Bothrops alternatus Zinc metalloproteinase-disintegrin alternagin
  • 貨號：
    CSB-MP315153BUS
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 別名：
    ; Zinc metalloproteinase-disintegrin-like alternagin; EC 3.4.24.-; Snake venom metalloproteinase; SVMP) [Cleaved into: Disintegrin-like alternagin-C; Alt-C)]; Fragment
  • 種屬：
    Bothrops alternatus (Urutu)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-196
  • 氨基酸序列
    IISPPVCGNE LLEVGEECDC GTPENCQNXC CDAATCKLKS GSQCGHXDCC EQCKFTKSGT ECRASMSECD PAEHCTGQSX XCXXDVFHKN GQPCLDNYGY CYNGNCPIMY HAQCYALFGA DVYEAEDSCF KDNQKGNYYG YCRKENXXXX XCXXXDVKCG RLYCKDNSPK QNNPCKMFYS NDDEHKGNVL PGTKCE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    hemorrhagic protease that acts as a potent inhibitor of collagen-induced adhesion by blockage of alpha-2/beta-1 (ITGA2/ITGB1) integrin. Cleaves at Leu-|-Met bonds.; Disintegrin alternagin-C: potent inhibitor of the collagen binding to alpha-2/beta-1 (ITGA2/ITGB1) integrin. Has a chemotactic activity on neutrophils and this effect involves actin cytoskeleton rearrangement, FAK, PI3-kinase and Erk-2 activities. Induces endothelial cell proliferation, and these effects are mediated at least in part by an increased expression of vascular endothelial growth factor (VEGF). In injured muscles, reduces both MMP-2 mRNA and gelatinolytic activity, suggesting that it changes the overall balance of extracellular matrix protein turnover during muscle regeneration. In low concentrations, induces formation of new vessels and up-regulates the expression of VEGF receptor 2 (KDR) without affecting VEGF receptor 1 (FLT1) expression. In high concentrations, strongly inhibits angiogenesis, and the expression of both receptors is down-regulated. Has very low plasma clotting activity.
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Venom metalloproteinase (M12B) family, P-III subfamily, P-IIIb sub-subfamily
  • 組織特異性：
    Expressed by the venom gland.


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