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  4. Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase ATX1 (ATX1), partial

Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase ATX1 (ATX1), partial

  • 中文名稱：
    Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase ATX1(ATX1) ,partial
  • 貨號：
    CSB-YP863210DOA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase ATX1(ATX1) ,partial
  • 貨號：
    CSB-EP863210DOA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase ATX1(ATX1) ,partial
  • 貨號：
    CSB-EP863210DOA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase ATX1(ATX1) ,partial
  • 貨號：
    CSB-BP863210DOA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Arabidopsis thaliana Histone-lysine N-methyltransferase ATX1(ATX1) ,partial
  • 貨號：
    CSB-MP863210DOA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ATX1
  • Uniprot No.：
  • 別名：
    ATX1; SDG27; SET27; TRX1; At2g31650; T9H9.17Histone H3-lysine(4) N-trimethyltransferase ATX1; EC 2.1.1.354; Protein SET DOMAIN GROUP 27; Protein-lysine N-trimethyltransferase ATX1-SoloSET; EC 2.1.1.-; Trithorax-homolog protein 1; TRX-homolog protein 1
  • 種屬：
    Arabidopsis thaliana (Mouse-ear cress)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binds to the promoter and regulates the transcription of target genes, maintaining them in an active state; at promoters, required for TATA binding proteins (TBPs, e.g. TBP1 and TBP2) and RNA polymerase II (Pol II) recruitment, and, in a subsequent event, is recruited by a phosphorylated form of Pol II to the +300-bp region of transcribed sequences to trimethylates nucleosomes. Histone trimethyltransferase that trimethylates 'Lys-4' of histone H3 (H3K4me3); H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation and is required for efficient elongation of transcription but not for transcription initiation. Methylates only a limited fraction of nucleosomes of target genes (e.g. FLC, NAP, XTH33 and WRKY70). Necessary for WDR5A occupancy at WRKY70 and LTP7 genes. Required to maintain the active state of class A (AP1 and AP2), class B (PI and AP3) and class C (AG, AGAMOUS) floral homeotic genes at early stages of flower development. Together with CLF, modulates AG nucleosome methylation statement. Involved in epigenetic regulation (e.g. H3K4me3) of the floral repressors FLC, FT and SOC1 to prevent the transition from vegetative to reproductive development, independently of the photoperiod; binds the active FLC locus before flowering, but this interaction is released upon the transition to flowering. Regulates floral organ identity and flowering transition. Functions as a receptor for the lipid messenger phosphatidylinositol 5-phosphate (PI5P), which regulates negatively its transcriptional activation activity. Exhibits histone methylase activity and subsequent transcriptional regulation on WRKY70 gene, and, to a lower extent on secondary defense-response targets salicylic acid (SA)-responsive gene PR1 and jasmonic acid (JA)-responsive gene THI2.1. Involved in response to dehydration stress-response in both abscisic acid (ABA)-dependent and ABA-independent pathways; this includes specific genes (e.g. COR15A, ADH1, CBF4, RD29A, RD29B, RD26, ABF3, NCED3 and ABA3) epigenetic regulation (e.g. H3K4me3 and Pol II recruitment) to promotes their transcription and influence ABA production. Implicated in stomatal closure regulation. Indirect repressor of XTH genes (XTH33). Necessary for the phosphorylation of Pol II NRPB1 (e.g. Ser5P and Ser2P) at the promoters of target genes, thus regulating both early and late stages of transcription. Controls root growth and architecture by regulating the timing of root development, stem cell niche maintenance (e.g. quiescent center (QC)), and cell patterning during primary and lateral root development. Modulates cell cycle duration, cell production, and the transition from cell proliferation in the root apical meristem (RAM) to cell elongation.; Trimethylates A4/EF1A post-translationally at Lys-396. Required for actin cytoskeleton organization.
  • 基因功能參考文獻：
    1. Our study provided genetic evidence for the first time that, copper ions necessary for ethylene receptor biogenesis and signaling are transported from ATX1 to RAN1. PMID: 28388654
    2. review of role in gene activation PMID: 25047977
    3. ATX1 is involved in the timing of root development, stem cell niche maintenance, and cell patterning during primary and lateral root development. PMID: 25205583
    4. We demonstrate that ATX1 and AtCOMPASS-like have distinct effects on PIC (transcription preinitiation complex )formation and the transition to transcription elongation. ATX1 and AtCOMPASS-like are required for efficient PIC formation. PMID: 23284292
    5. overexpression of ATX1 resulted in hypersensitivity to severe Cu deficiency... However, overexpression of mutated ATX1, replacing the Cu-binding motif MXCXXC with MXGXXG, abolished the hypersensitivity... PMID: 22899077
    6. Loss of ATX1 function caused lower seed germination, larger stomatal apertures, increased water loss and sensitivity to dehydration stress. PMID: 21309869
    7. A novel member of the Trithorax family with a role unrelated to chromatin is encoded from an internal promoter in the ATX1 locus as an isoform containing only the SET domain (soloSET). PMID: 21245040
    8. ATX1 exhibited two distinct roles in facilitating TBP and Pol II occupancy at promoters and in H3K4 trimethylation within the transcribed region. PMID: 21266657
    9. discovery of a mechanistic link between a chromatin modifying activity (ATX1) and a lipid (PtdIns5P) synthesis in a signaling pathway that ultimately results in altered expression of ATX1 dependent genes downregulated in response to dehydration stress PMID: 20967218
    10. study identified an overlapping set of genes co-regulated by ATX1 and AtMTM under drought conditions; propose that these shared genes represent ultimate targets of partially overlapping branches of the pathways of nuclear ATX1 and cytoplasmic AtMTM1 PMID: 19901554
    11. ATX1 is involved in methylating histone H3- lysine 4 of only a fraction of Arabidopsis nucleosomes. PMID: 16157865
    12. Data show that ATX1 function in the epigenetic regulation of the floral repressor FLOWERING LOCUS C (FLC). PMID: 18375656
    13. Results show that ATX1 proteins methylate K4 of histone H3 and trimethylates it. PMID: 18375658
    14. ATX1 was found involved in the developmental and adaptation processes of the plant. PMID: 19412892

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  • 亞細胞定位：
    [Isoform 1]: Nucleus. Cytoplasm.; [Isoform 3]: Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, TRX/MLL subfamily
  • 組織特異性：
    [Isoform 1]: Strongly expressed in cotyledons, but weak levels in the first true leaves, except at the hydothodes. Ubiquitous with higher levels in dividing tissues, including inflorescence meristem and flower primordia. Expressed also in leaves (especial
  • 數據庫鏈接：

    KEGG: ath:AT2G31650

    STRING: 3702.AT2G31650.1

    UniGene: At.14356



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