在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Apis mellifera Melittin (MELT)

In Stock
  • 中文名稱:
    Recombinant Apis mellifera Melittin(MELT)
  • 貨號:
    CSB-EP355665DNK
  • 規格:
    ¥3324
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    MELT
  • Uniprot No.:
  • 別名:
    MELT; Melittin; MEL; MLT; Allergen Api m 3; Allergen Api m III; allergen Api m 4
  • 種屬:
    Apis mellifera (Honeybee)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    2.8 kDa
  • 表達區域:
    44-69aa
  • 氨基酸序列
    GIGAVLKVLTTGLPALISWIKRKRQQ
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    Tag-Free
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Melittin: Main toxin of bee venom with strong hemolytic activity and antimicrobial activity. It has enhancing effects on bee venom phospholipase A2 activity. This amphipathic toxin binds to negatively charged membrane surface and forms pore by inserting into lipid bilayers inducing the leakage of ions and molecules and the enhancement of permeability that ultimately leads to cell lysis. It acts as a voltage-gated pore with higher selectivity for anions over cations. The ion conductance has been shown to be voltage-dependent. Self-association of melittin in membranes is promoted by high ionic strength, but not by the presence of negatively charged lipids. In vivo, intradermal injection into healthy human volunteers produce sharp pain sensation and an inflammatory response. It produces pain by activating primary nociceptor cells directly and indirectly due to its ability to activate plasma membrane phospholipase A2 and its pore-forming activity.; Melittin-S: 1.4-fold less hemolytic and adopts a less organized secondary structure than melittin.; Melittin-2: Has strong hemolytic activity.
  • 基因功能參考文獻:
    1. this study shows that melittin constrains the expression of identified key genes associated with bladder cancer PMID: 29854840
    2. Molecular dynamics simulation was performed to characterize the structure and interaction of melittin with lipid molecules in dimyristoylphosphatidylglycerol bilayers. The simulation results indicate that basic amino acid residues in melittin interact strongly with lipid head groups to generate a pseudo-transmembrane alignment. PMID: 28165239
    3. All-atom/coarse-grained approach simulations demonstrated a clear salt effect and a moderate temperature effect on aggregation and support the molten globule model of melittin aggregates. PMID: 28636825
    4. Taking uPA(1-43) amino acids specifically binding to uPAR as targeted part of fusion protein, and making use of antitumor activity of melittin, the recombinant fusion protein it was able to inhibit growth of ovarian tumors . PMID: 25394558
    5. These findings point to the preservation and, from more aqueous solvent conditions, the formation of an at least partially helical form of melittin in the gas-phase. PMID: 21701716
    6. isolation and biochemical characterization of melittin-S, an isoform of melittin comprising a Ser residue at the 10th position, from the venom of Africanized A. mellifera; seasonal variation in venom content of melittins PMID: 20472009
    7. This paper characterizes the quantitative parameters of the peptide-lipid interactions related to the mechanism of formation of toroidal pores by melittin, compared to the formation of barrel-stave pores by alamethicin. PMID: 15035629
    8. melittin is localized in a motionally restricted region in membranes; increasing unsaturation in membranes causes a considerable change in the secondary structure of membrane-bound melittin PMID: 15471568
    9. from a kinetics point of view, the formation of the alpha-helix is a consequence of the membrane insertion of melittin. The rate of melittin folding was found to be influenced by the lipid composition of the bilayer. PMID: 15533303
    10. Melittin does not block NF-kappa B-p50-DNA interactions; rather, the human cells tested show significantly increased mRNA levels of several inflammatory genes, elevated cyclooxygenase-2 protein levels, and release of large quantities of oxygen radicals. PMID: 17579088
    11. increases in plasma adrenaline, noradrenaline, vasopressin levels and renin activity mediate the pressor responses to melittin in normal and hypotensive conditions in rats PMID: 17897713

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Target cell membrane.
  • 蛋白家族:
    Melittin family
  • 組織特異性:
    Expressed by the venom gland.
  • 數據庫鏈接:

    KEGG: ame:406130

    STRING: 7460.GB10355-PA

    UniGene: Ame.1212



主站蜘蛛池模板: 激情综合婷婷丁香五月情| 人妻熟人中文字幕一区二区| 免费国产h视频在线观看| 国产精品点击进入在线影院高清 | 国产日韩欧美| 国产xxxxx在线观看| 日本人妻中文字幕乱码系列| 成人午夜精品无码一区二区三区| 极品新婚夜少妇真紧| 脱了美女内裤猛烈进入gif| 西西人体大胆瓣开下部毛茸茸| 日本亲子乱子伦xxxx50路| 伊人久久大香线蕉综合中文字幕| 日韩网红少妇无码视频香港| 97一区二区国产好的精华液| 久久亚洲精品中文字幕一区| av大片在线无码免费| 极品白嫩的小少妇| 777精品久无码人妻蜜桃| 日本亚洲欧洲另类图片| 国内精品久久久久av福利秒拍| 老鲁夜夜老鲁| 国产寡妇偷人在线观看| 中国少妇内射xxxxx-百度 | 国产产无码乱码精品久久鸭| 国精品人妻无码一区二区三区蜜柚| 一本热久久sm色国产| 人妻中文无码久热丝袜| 高清破外女出血av毛片| 国产色情又大又粗又黄的电影| ā片在线观看免费观看| 欧美黑人欧美精品刺激| 成人自慰女黄网站免费大全| 极品少妇被猛的白浆直喷白浆| 免费纯肉3d动漫无码网站| 春药玩弄少妇高潮吼叫| 亚瑟av亚洲精品一区二区| 搡老熟女老女人一区二区| 久久av无码aⅴ高潮av喷吹| 亚洲综合激情五月丁香六月| 欧美精品黑人粗大视频|