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Histone H1.0 Recombinant Monoclonal Antibody

  • 中文名稱:
    組蛋白 H1.0重組抗體
  • 貨號:
    CSB-RA010087A0HU
  • 規格:
    ¥1320
  • 其他:

產品詳情

  • 產品描述:
    CSB-RA010087A0HU 是一款針對核心連接組蛋白H1.0設計的高特異性科研抗體。該靶蛋白作為染色質結構的關鍵調控因子,通過參與核小體間連接維持基因組穩定性,并在細胞分化、基因沉默及表觀遺傳調控中發揮重要作用。本產品經ELISA平臺嚴格驗證,展現優異的抗原結合能力與批次間一致性,可精準識別天然構象的Histone H1.0蛋白。其重組單克隆抗體技術確保低交叉反應性和高重復性,適用于染色質動態分析、表觀遺傳修飾研究、基因表達譜解析等基礎科研領域,尤其在探索細胞周期調控、干細胞分化機制及腫瘤發生相關染色質重塑過程中具有重要應用價值,為核蛋白功能研究和表觀遺傳學模型構建提供可靠工具。
  • Uniprot No.:
  • 基因名:
    H1F0
  • 別名:
    H1 histone family member 0 antibody; H1(0) antibody; H10 antibody; H10_HUMAN antibody; h1f0 antibody; H1FV antibody; Histone H1'' antibody; Histone H1(0) antibody; Histone H1.0 antibody; Histone H10 antibody; Histone H5 antibody; MGC5241 antibody; N-terminally processed antibody
  • 反應種屬:
    Human
  • 免疫原:
    A synthesized peptide
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    1C7
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
  • 基因功能參考文獻:
    1. H1.X moves more rapidly than other linker histones in vivo Domain swapping between H1.0 and H1.X suggests that the globular domain (GD) and C-terminal domain (CTD) of H1.X independently contribute to the dynamic behavior of H1.X. PMID: 27528617
    2. this study shows that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. PMID: 27708074
    3. The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 and H1c. PMID: 22334665
    4. nuclear transport of H1 histones requires a heterodimeric nuclear import receptor PMID: 12080050
    5. H1(0)histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1(0) expression. PMID: 12149419

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  • 亞細胞定位:
    Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
  • 蛋白家族:
    Histone H1/H5 family
  • 數據庫鏈接:

    HGNC: 4714

    OMIM: 142708

    KEGG: hsa:3005

    STRING: 9606.ENSP00000344504

    UniGene: Hs.745024



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