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  4. GPA33 Recombinant Monoclonal Antibody

GPA33 Recombinant Monoclonal Antibody

  • 中文名稱：
    GPA33重組抗體
  • 貨號：
    CSB-RA245537A0HU
  • 規格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA245537A0HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA245537A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA245537A0HU GPA33重組單克隆抗體是針對人源糖蛋白A33（GPA33）設計的高特異性科研工具。GPA33作為一種跨膜糖蛋白，在正常胃腸道上皮細胞和結直腸癌等腫瘤組織中特異性表達，其參與細胞間粘附及信號調控的功能使其成為胃腸道腫瘤微環境研究的重要靶點。本抗體采用重組技術制備，經ELISA和免疫組化（IHC）雙重驗證，在IHC應用中推薦使用1:50至1:200的稀釋比例，能清晰顯示石蠟包埋組織中靶蛋白的定位與表達水平，背景信號低且重復性優異。該產品適用于胃腸道腫瘤病理學分析、腫瘤標志物篩選及細胞膜表面蛋白功能研究，可為探索GPA33在腫瘤發生發展中的分子機制、評估腫瘤組織特異性表達模式提供可靠支持，同時滿足體外實驗中對蛋白互作及信號通路研究的精準檢測需求。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cell surface A33 antigen (Glycoprotein A33), GPA33
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human GPA33
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    4H4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May play a role in cell-cell recognition and signaling.
  • 基因功能參考文獻：
    1. A33 shows similar sensitivity to but is more specific than CDX2 as an immunomarker of colorectal carcinoma PMID: 28226180
    2. A33 expression is directly correlated to colorectal tumor differentiation. PMID: 27272411
    3. Data indicate that EpCAM- and A33-Exos were released from the apical and basolateral surfaces, respectively. PMID: 23230278
    4. Data indicate positive staining was observed for both A33 expression and KRN330 binding from patients biopsied on Day 8, 9 or 14 following initial dosing of 3 mg/kg. PMID: 23294608
    5. The A33-dependent incorporation of B5 into extracellular enveloped vaccinia virions is mediated through an interaction between their lumenal domains. PMID: 22623777
    6. Increased interaction between vaccinia virus proteins A33 and B5 is detrimental to infectious extracellular enveloped virion production. PMID: 22623782
    7. cloning, chromosomal localizations, exon-intron structures and transcription start sites - target gene for the intestine-specific homeobox transcription factor, CDX1. PMID: 12114523
    8. Regulation of A33 antigen expression by GKLF. PMID: 12853980
    9. This work has demonstrated that the antigen is both highly immobile and extremely persistent-retaining its surface localization for a turnover halflife of greater than 2 days. PMID: 18236042

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.
  • 數據庫鏈接：

    HGNC: 4445

    OMIM: 602171

    KEGG: hsa:10223

    STRING: 9606.ENSP00000356842

    UniGene: Hs.651244



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