在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DKK1 Recombinant Monoclonal Antibody

  • 中文名稱(chēng):
    DKK1重組抗體
  • 貨號(hào):
    CSB-RA576260A0HU
  • 規(guī)格:
    ¥1320
  • 圖片:
    • Western Blot
      Positive WB detected in: 293 whole cell lysate
      All lanes: DKK1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 29 kDa
      Observed band size: 38 kDa
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    CSB-RA576260A0HU DKK1重組單克隆抗體是特異性識(shí)別Dickkopf相關(guān)蛋白1(DKK1)的高性能檢測(cè)工具。DKK1作為Wnt信號(hào)通路的拮抗劑,在胚胎發(fā)育、骨代謝調(diào)控及腫瘤發(fā)生等過(guò)程中發(fā)揮重要作用。本抗體經(jīng)ELISA和蛋白質(zhì)印跡(WB)雙平臺(tái)驗(yàn)證,能有效識(shí)別天然構(gòu)象的DKK1蛋白,在WB實(shí)驗(yàn)中推薦使用1:500至1:5000的寬范圍稀釋梯度,適用于不同實(shí)驗(yàn)體系的需求。質(zhì)控?cái)?shù)據(jù)顯示其具有優(yōu)異的特異性,能精準(zhǔn)區(qū)分目標(biāo)蛋白與其他DKK家族成員,且經(jīng)多批次驗(yàn)證表現(xiàn)出穩(wěn)定的結(jié)合活性與低背景特性。該抗體適用于探索Wnt信號(hào)通路調(diào)控機(jī)制、腫瘤微環(huán)境研究以及骨代謝相關(guān)疾病的基礎(chǔ)科研,特別在檢測(cè)細(xì)胞裂解液或組織樣本中DKK1的表達(dá)水平變化時(shí)展現(xiàn)出高靈敏度和重復(fù)性。其重組單克隆抗體的特性確保了實(shí)驗(yàn)數(shù)據(jù)的高度一致性,為研究DKK1在細(xì)胞分化、癌癥轉(zhuǎn)移或骨形成異常等領(lǐng)域的生物學(xué)功能提供了可靠工具。
  • Uniprot No.:
  • 基因名:
  • 別名:
    Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK), DKK1
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    A synthesized peptide derived from human DKK1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類(lèi)型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號(hào):
    1D12
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity.
  • 基因功能參考文獻(xiàn):
    1. Results provide evidence that DKK-1 is involved in the progression of prostate cancer (PC). DKK-1-mediated inhibition of osteoblasts, which contributes to tumor progression and osteolytic metastases, may also play a role in the development of metastases with osteoblastic features. PMID: 30116403
    2. our findings suggest that glucocorticoid-induced expression of Dkk-1 could be a key factor in modulating the differentiation ability of MSCs used for osteonecrosis of the femur head and other stem cell therapies. PMID: 29084466
    3. MicroRNA152 inhibits cell proliferation of osteosarcoma through DKK1. PMID: 29845282
    4. this study shows that DKK1 is increased in vitiligo in lesional and peri-lesional skin of acral and non-acral lesions PMID: 29605863
    5. Dkk-1 and PTH levels in psoriatic arthritis are lower than healthy female controls, in contrast with rheumatoid arthritis, in which they are increased PMID: 28634697
    6. this study suggests that higher expression of DKK1 in the dermis induced senescence in melanocytes that may lead to hypopigmentation and play role in vitiligo pathogenesis PMID: 29442138
    7. TNF-alpha, DKK1, and OPG have roles in pathogenesis of knee osteoarthritis PMID: 28676900
    8. Serum level of DKK-1 is elevated in patients with rheumatoid arthritis (RA) compared to healthy controls, suggesting an important role of DKK-1 in the pathogenesis and treatment of RA [review]. PMID: 29665496
    9. the staining intensity of DKK1 was significantly stronger in the placentas of the severe preeclampsia group PMID: 29603045
    10. Serum OPN and DKK1 levels of hepatocellular carcinoma patients could be considered as novel biomarkers showing prognostic significance after hepatectomy based on long-term survival data PMID: 29753515
    11. These findings suggested that decreased circulating DKK-1 levels are associated with the development and severity of exudative age-related macular degeneration, and have potential to become a biomarker for exudative age-related macular degeneration. PMID: 28455497
    12. In patients with rheumatoid arthritis, higher levels of DKK1 were found in patients with lower functional status.This could be explained by more structural damage; DKK1 could be used as a biomarker of joint destruction in RA. PMID: 29282619
    13. The Dickkopf-1 (DKK1) is a secreted inhibitor of beta-catenin-dependent Wnt signalling and was originally characterized as a tumour suppressor based on the prevailing view that Wnt signalling promotes cancer pathogenesis. PMID: 28574171
    14. Collectively, our data strongly suggest that stress-related neurohormones, such as GCs, cause DP cells to secrete DKK1, which in turn inhibits hair growth. PMID: 28155238
    15. the inhibitory effects of silencing miR-217 on stem cell properties and Wnt signaling were reversed by the downregulation of DKK1 in miR-217-downregulated cells. Therefore, our results indicate that miR-217 plays a vital role in the CSC-like phenotypes of Hepatocellular carcinoma (HCC) cells and may be used as a potential therapeutic target against HCC. PMID: 28849121
    16. In our cohort of pregnant women, sclerostin and DKK1 were not associated with any adverse metabolic profile, and possibly do not play relevant roles in the pathophysiology of gestational diabetes mellitus. PMID: 28277306
    17. Serum DKK-1 levels in axial spondyloarthritis depend on disease duration. As disease duration increases, DKK-1 serum levels decrease. PMID: 27297260
    18. inhibition of the mTOR pathway increases sensitivity of melanoma cells towards temozolomide, which is associated with enhanced expression of the Wnt antagonist DKK1 PMID: 28423208
    19. Inhibition of DKK1 expression effectively decrease plaque stability by attenuating endoplasmic reticulum stress-mediated cellular apoptosis through intiating the JNK pathway and inhibiting Wnt/betacatenin and following by activation of the IRE1alpha and eif2alpha/CHOP pathways. PMID: 28703797
    20. This study demonstrated that DKK-1 may be a predictor for prognosis in pancreatic ductal adenocarcinoma patients. PMID: 28749252
    21. synovial fluid Dkk-1 levels are positively related to the severity of joint damage in knee osteoarthritis. PMID: 28451870
    22. DKK1 exerts its pro-invasion function at least in part through the beta-catenin/ MMP-7 signaling pathway, suggesting DKK1 as a potential therapeutic target for human hilar cholangiocarcinoma (HCCA). PMID: 27608843
    23. Sclerostin But Not Dickkopf-1 has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women PMID: 27289555
    24. High serum levels of sclerostin and Dkk-1 are associated with acute ischaemic stroke PMID: 27573735
    25. regulated by Dkk-1 secreted by Multiple Myeloma cells and is a potential mechanism contributing to the osteoblast dysfunction noted in Multiple Myeloma. PMID: 26763740
    26. DKK1 c.121G>A (p.(A41T)) variant was identified in the family with Chiari malformation type 1. Screening of DKK1 in a cohort of 65 CMI sporadic patients identified another missense variant, the c.359G>T (p.(R120L)), in two unrelated patients. PMID: 28513615
    27. LRP6 ectodomain becomes highly compact upon complexation with the Wnt antagonist Dkk1, suggesting a potential role for the ectodomain conformational change in the regulation of receptor oligomerization and signaling. PMID: 28052259
    28. Our results suggest that measurement of DKK-1 combined with DKK-1 autoantibodies is a potentially valuable tool for the early detection of ESCC. PMID: 26988995
    29. TET1 potently inhibited canonical Wnt/beta-catenin signaling by demethylating and upregulating two upstream antagonists of this pathway, SFRP2 and DKK1, which was associated with inhibition of EMT and cancer cell metastasis. PMID: 28851501
    30. This is the first study demonstrating a link between B cell depletion and skin Dkk-1 upregulation in patients with systemic sclerosis PMID: 27208972
    31. We found significantly increased levels of DKK-1 in patients with acute CO poisoning, compared to healthy controls. High levels of serum DKK-1 in patients were significantly correlated with severe neurological symptoms. PMID: 27353797
    32. DKK1 prevents lung metastasis of breast cancer cells but promotes breast-to-bone metastasis. PMID: 28892080
    33. Structure of the dual-mode Wnt regulator Kremen1 and insight into ternary complex formation with LRP6 and DKK1 have been presented. PMID: 27524201
    34. Expression of Cancer stem cells-associated DKK1 mRNA might be an unfavorable prognostic marker for patients with hepatocellular carcinoma. PMID: 28870909
    35. In chronic kidney disease, serum levels of the Wnt inhibitors DKK1 and sclerostin are unrelated, indicating different sites of origin and/ or different regulatory mechanisms. Sclerostin, as opposed to DKK1, may qualify as a biomarker of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD), particularly in dialysis patients. PMID: 28493902
    36. endogenous expression of the WNT antagonists DKK1 and FRZB is necessary for multiple steps during chondrogenesis PMID: 27733096
    37. The expression level of DKK1 in serum was increased in breast cancer patients, suggesting that serum expression level of DKK1 could be a useful biomarker in breast cancer. PMID: 28248066
    38. Results show that the expression of DKK1 is elevated in human HBV-related hepatocellular carcinoma tissues. PMID: 28419472
    39. DKK-1 and PDCD5 can be independent predictors of overall survival in patients suffering from chondrosarcoma. PMID: 27255549
    40. In patients with hepatocellular carcinoma serum DKK1 level correlated with tumor size, consequently, patients with bigger tumors tend to have higher levels of DKK1. PMID: 27161933
    41. Our results indicate that DKK1 and SFRP1 may be potentially useful biomarkers for evaluating the beneficial effects of long-term exercise on physical fitness and metabolism as well as the prognosis of patients with cancer. PMID: 28178355
    42. Dickkopf-1 and sclerostin were never correlated with each other or with bone turnover markers patients with Paget's disease of bone PMID: 28054306
    43. these findings suggest that DKK1 induces the occurrence of epithelial-mesenchymal transition and promotes migration and invasion in non-small cell lung cancer cells. Mechanically, b-catenin plays a vital role in DKK1-induced non-small cell lung cancer cell migration and invasion, and DKK1 inhibits the phosphorylation of b-catenin, resulting in the increased nuclear localization of b-catenin. PMID: 28677426
    44. Results suggest that miR-107 is likely to inhibit the occurrence and development of osteosarcoma by down-regulating Dkk-1 via the Wnt/beta-catenin signaling pathway. PMID: 28682874
    45. Recombinant Dkk1 suppresses beta-catenin target genes in myeloid-derived suppressor cells (MDSCs) from mice and humans and anti-Dkk1 loses its antitumor effects in mice lacking beta-catenin in myeloid cells or after depletion of MDSCs, demonstrating that Dkk1 directly targets MDSCs. PMID: 27045006
    46. Luciferase-fused 3' untranslated region of human Dickkopf1 activity was highly upregulated in A1CF-overexpressed MCF7 cells, but this upregulation can be inhibited by mutating conserved binding motifs of Dickkopf1 3' untranslated region. A1CF played a crucial role in cell migration and survival through affecting 3' untranslated region of Dickkopf1 to upregulate its expression in MCF7 cells. PMID: 28639893
    47. Circulating sclerostin and Dickkopf-1 levels do not change across the menstrual cycle and do not demonstrate any relationship with estradiol in premenopausal women. PMID: 27601021
    48. Results found miR-203 and DKK1 to be expressed at differential levels in cisplatin-sensitive and -insensitive lung adenocarcinoma tissues; there was also a negative correlation between them. PMID: 28350100
    49. Serum levels of OPG and DKK-1 were measured in 97 rheumatoid arthritis patients who were treated according to a treat-to-target strategy (T2T) aimed at remission (DAS28<2.6). PMID: 27911913
    50. DKK1 can promote vasculogenic mimicry formation via induction of the expression of epithelial-mesenchymal transition and cancer stem-like cell-related proteins. PMID: 27240974

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    Dickkopf family
  • 組織特異性:
    Placenta.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 2891

    OMIM: 605189

    KEGG: hsa:22943

    STRING: 9606.ENSP00000363081

    UniGene: Hs.40499



主站蜘蛛池模板: 日韩在线一区二区不卡视频| 怡红院a∨人人爰人人爽| 亚洲欧美日韩综合一区| 狠狠色丁香婷婷综合尤物 | 中文字幕丰满乱子无码视频| 亚洲午夜福利院在线观看| 美女脱了内裤张开腿让男人桶网站| 西西人体做爰大胆gogo| 免费人成网站在线观看欧美 | 狠日狠干日日射| 秋霞特色aa大片| 中文在线а√天堂官网| 久久精品人人做人人爽老司机| 久久精品中文字幕有码| 人人人妻人人澡人人爽欧美一区| 国产精品无码一区二区在线| 亚洲国产av天码精品果冻传媒| 成人性无码专区免费视频| 肉色超薄丝袜脚交一区二区| 国产精品久久久亚洲| 人妻综合专区第一页| 亚洲精品久久久一区| 国产999精品成人网站| 日韩精品一卡2卡三卡4卡| 国产一区二区不卡在线看| 国产精品久久| 国产午夜无码视频在线观看| 在线岛国片免费无码av| 999国内精品永久免费观看| 18禁止看的免费污网站| 西西人体大胆午夜啪啪| 亚洲人成网站18禁止大| 久久精品国产一区二区电影| 波多野结衣av无码| 永久免费男同av无码入口| 国产很色很黄很大爽的视频| 国内老熟妇对白xxxxhd| 国产熟女亚洲精品麻豆| 国产果冻豆传媒麻婆| 国产丰满老熟妇乱xxx1区| 人妻无码一区二区三区免费|