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DDX6 Recombinant Monoclonal Antibody

  • 中文名稱：
    DDX6重組抗體
  • 貨號：
    CSB-RA180423A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA180423A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA180423A0HU DDX6重組單克隆抗體是針對RNA解旋酶家族成員DDX6研發(fā)的高特異性檢測工具。該抗體靶向的DDX6蛋白是DEAD-box蛋白家族的重要成員，參與mRNA代謝調(diào)控、應(yīng)激顆粒形成及microRNA介導(dǎo)的基因沉默等關(guān)鍵生物學(xué)過程。經(jīng)嚴(yán)格驗(yàn)證，本產(chǎn)品在ELISA實(shí)驗(yàn)中展現(xiàn)出優(yōu)異的抗原結(jié)合能力，免疫組化（IHC）應(yīng)用時(shí)推薦使用1:50-1:200稀釋度，可在組織樣本中精準(zhǔn)定位DDX6蛋白的亞細(xì)胞分布，染色結(jié)果背景低、信號明確。作為重組單克隆抗體，其具有高度均一的批次穩(wěn)定性和可重復(fù)性，適用于探究RNA加工機(jī)制、細(xì)胞應(yīng)激反應(yīng)調(diào)控、胚胎發(fā)育相關(guān)研究以及腫瘤等疾病模型中基因表達(dá)異常的分子機(jī)制解析。該產(chǎn)品專為科研實(shí)驗(yàn)設(shè)計(jì)，可為RNA代謝研究、信號通路分析及蛋白質(zhì)功能探索提供可靠工具。
  • Uniprot No.：
  • 基因名：
    DDX6
  • 別名：
    Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK), DDX6, HLR2 RCK
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human DDX6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6D8
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
  • 基因功能參考文獻(xiàn)：
    1. Results provide evidence for a dual mechanisms regulating the nucleocytoplasmic localization of DDX6. First, data show that DDX6 can be transported by 4E-T in a piggyback manner. Furthermore, a novel nuclear targeting mechanism was detected in which DDX6 enters the newly formed nuclei by "hitch-hiking" on mitotic chromosomes with its C-terminal domain during M phase progression. PMID: 28216671
    2. Results showed that DDX6 protein was overexpressed in gastric cancer (GC) and provided evidence that DDX6 acted as an upstream molecule that positively regulated the expression of HER2 and FGFR2 at the post-transcriptional step in GC cells. PMID: 29987267
    3. These findings imply a novel function for DDX6 as an RNA co-sensor and signaling enhancer for RIG-I. PMID: 29949917
    4. Identification of the DEAD box RNA helicase DDX6 as a new partner that acts in cooperation with Tau to increase miRNA activity. PMID: 29966762
    5. DDX6 modulates interaction of miR-122 with the 5' untranslated region of hepatitis C virus RNA. PMID: 28456022
    6. we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis. PMID: 27342281
    7. miRNAs, AGOs, GW182, the CCR4-NOT complex, and DDX6/Me31B repress and degrade polyadenylated mRNA targets that are translated via scanning-independent mechanisms in both human and Drosophila melanogaster cells PMID: 27009120
    8. DDX6 may have a role in radio- and chemoresistance in glioblastoma PMID: 26783102
    9. Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility. PMID: 26610392
    10. DDX6 repression complexes are required for P-body assembly. PMID: 25995375
    11. Protein Interactome Analysis of DDX6 PMID: 26184334
    12. Results indicate that progenitor function is maintained by DDX6 complexes through two distinct pathways that include the degradation of differentiation-inducing transcripts and by promoting the translation of self-renewal and proliferation mRNAs. PMID: 26412305
    13. CNOT1 facilitates recruitment of DDX6 to miRNA-targeted mRNAs, placing DDX6 as a downstream effector in the miRNA silencing pathway. PMID: 25035296
    14. study discovered multiple susceptibility variants for systemic lupus erythematosus in the 11q23.3 region, including variants in/near PHLDB1 (rs11603023), DDX6 (rs638893) and CXCR5 (rs10892301) PMID: 24001599
    15. Crystal structures of the DDX6, CNOT1 and CNOT9 complexes. PMID: 24768538
    16. Crystal structure of the DDX6, CNOT9 and CNOT1 complex. PMID: 24768540
    17. DDX6 and miR-122 modulate HCV through distinct pathways. PMID: 23826300
    18. data indicate that P-body assembly occurs in a step-wise manner, where Rck participates in the initial suppression of mRNA translation, whereas Pat1b in a second step triggers P-body assembly and promotes mRNA decapping PMID: 23535175
    19. High DDX6 expression is associated with gastric cancer. PMID: 23932921
    20. We identified several unbalanced aberrations and a t(11;14) involving IGH and DDX6 providing evidence for a contribution of DDX6 to lymphomagenesis by deregulation of BCL6 in NMZL. PMID: 22965301
    21. DEAD-box RNA helicase 6 (DDX6) is a cellular modulator of vascular endothelial growth factor expression under hypoxia PMID: 23293030
    22. Rck/p54 recruitment by sequence-specific translational repressors leads to further binding of Rck/p54 along mRNA molecules, resulting in their masking, unwinding, and ultimately recruitment to P-bodies. PMID: 22836354
    23. assembling HIV-1 co-opts a preexisting host complex containing cellular facilitators such as DDX6, which the virus uses to catalyze capsid assembly PMID: 22851315
    24. Data show that DDX6 is required for efficient assembly or release of infectious Dengue virus. PMID: 21957497
    25. stud finds that DDX6 is required for efficient genome packaging of foamy virus, a spumaretrovirus PMID: 22022269
    26. RCK is a functional partner of TTP in promoting TTP-mediated translational repression of AU-rich mRNA PMID: 22203041
    27. data suggest that in premature erythroid cells translational silencing of hr15-LOX mRNA is maintained by DDX6 mediated storage in these RNP granules PMID: 20884783
    28. DDX6 helicase activity is essential for efficient hepatitis C virus replication, reflecting essential roles for DDX6 in hepatitis C virus genome amplification and/or maintenance of cellular homeostasis. PMID: 20392846
    29. In the Australian GWAS, one SNP achieved genomewide significance for comorbid AD/ND, rs1784300 near DDX6 on chromosome 11 (p = 2.60 x 10(-9)). PMID: 20158304
    30. DEAD-box helicase rck/p54, is involved in post-transcriptional regulation of APP, as its overexpression in cultured cells results in elevated levels of APP mRNA and protein PMID: 18378046
    31. Rck/p54 protein is possibly involved in the replication of HCV genomes in hepatocytes and in carcinogenesis of hepatocellular carcinoma. PMID: 12823589
    32. The Over-expression of RCK-p54 protein in HeLa cells caused growth inhibition and cell cycle arrest at G2/M with down-regulation of c-myc expression. PMID: 16611246
    33. Study shows that RCK/p54, a DEAD box helicase, interacts with Ago1 and Ago2, in active siRISC or miRISC from human cells; directly interacts with Ago1 and Ago2 in vivo, facilitates formation of P-bodies, and is a general repressor of translation. PMID: 16756390
    34. ataxin-2 interacts with the RNA helicase DDX6 PMID: 17392519
    35. RCK/ p54 might be a determinant of colorectal cancer proliferation by activating the canonical Wnt pathway PMID: 18769115
    36. Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. PMID: 19285948
    37. The role of the p54 helicase activity in translational repression and in P-body formation, was examined. PMID: 19297524

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  • 相關(guān)疾病：
    A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32).
  • 亞細(xì)胞定位：
    Cytoplasm, P-body. Cytoplasm. Nucleus.
  • 蛋白家族：
    DEAD box helicase family, DDX6/DHH1 subfamily
  • 組織特異性：
    Abundantly expressed in most tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2747

    OMIM: 600326

    KEGG: hsa:1656

    STRING: 9606.ENSP00000264018

    UniGene: Hs.408461



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