在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. ZYX Recombinant Monoclonal Antibody

ZYX Recombinant Monoclonal Antibody

  • 中文名稱：
    ZYX Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA032877A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing 786-O cells stained with CSB-RA032877A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ZYX antibody; Zyxin antibody; Zyxin-2 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human ZYX
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    8F2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.
  • 基因功能參考文獻(xiàn)：
    1. Study findings identify zyxin as a physiological regulator of endothelial exocytosis through reorganizing local actin network in the final stage of exocytosis. Zyxin downregulation inhibits the secretion of VWF from human primary endothelial cells. PMID: 28256511
    2. these observations suggest that Zyxin promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8-mediated YAP activation. PMID: 29967145
    3. Increased zyxin expression is associated with asthma. PMID: 28278518
    4. Zyxin binding to Ptc2 is due to the interaction of Zyxin 2nd LIM-domain (530-590 aa) with the under-membrane region of the cytoplasmic C-terminus of Ptc2 (1159-1412 aa). PMID: 27125030
    5. ZYX gene may be aging-related gene and involved in Osteoporosis. PMID: 25771989
    6. key regulator of stretch-induced gene expression at the cellular level PMID: 26071033
    7. Matrix density alters zyxin phosphorylation, which limits peripheral process formation and extension in endothelial cells invading 3D collagen matrices. PMID: 25038525
    8. Zyxin, which is thought to be essential for tight cell-to-cell junctions, decreased 1.8-fold in TNF-alpha-treated human brain microvascular endothelial cells. PMID: 25025691
    9. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. PMID: 24036928
    10. Zyxin is a novel target for beta-amyloid peptide activities in Alzheimer's disease. PMID: 23330981
    11. Zyxin is suggested to promote growth, migration and invasiveness of fibroblastic type oral squamous cell carcinoma cells by upregulating Rac1 and Cdc42. PMID: 23292068
    12. A stretch-induced signaling pathway in vascular cells leads to the activation of zyxin, a cytoskeletal protein specifically involved in transducing mechanical stimuli. PMID: 23233529
    13. RA-induced cancer cell cytotoxicity was significantly impaired by Zyxin or PTOV1. Overall, our findings suggest that Zyxin and PTOV1 should be considered as critical determinants in cancer therapy with retinoids PMID: 23321499
    14. Zyxin is a transforming growth factor-beta (TGF-beta)/Smad3 target gene that regulates lung cancer cell motility via integrin alpha5beta1. PMID: 22778267
    15. Zyxin phenotype is mediated by partners alpha-actinin and p130Cas and ensures that motile cells in a three-dimensional matrix explore the largest space possible in minimum time. PMID: 22395610
    16. Depletion of nectin-2 from L cells expressing E-cadherin results in a loss of zyxin localization to cell-cell contacts, demonstrating that the zyxin-nectin interaction plays a critical role in zyxin targeting to these sites. PMID: 22056563
    17. LIM domain of zyxin recruits zyxin to force-bearing sites at the leading edge of migrating cells PMID: 21889443
    18. Findings suggest an unforeseen role for Zyxin in DNA damage-induced cell fate control through modulating the HIPK2-p53 signaling axis. PMID: 21248071
    19. Zyxin, whose expression is negatively regulated by microRNA-16 (miR-16), is confirmed to be a direct target gene of miR-16. Overexpression of zyxin could also restrain cell movement and enhance cell-cell adhesion. PMID: 21360639
    20. Stretch appears to be an important factor in the development of endothelial dysfunction with zyxin as a potential therapeutic target to interfere with these early changes in endothelial cell phenotype PMID: 20705921
    21. The LIM domain protein zyxin was identified as an interaction partner for human synemin. PMID: 19853601
    22. This study establishes a crucial role of zyxin in thrombin signaling in endothelial cells and provides evidence for a novel PAR-1 signaling pathway mediated by zyxin. PMID: 19690217
    23. LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions PMID: 15004028
    24. Within Ewing tumor cells, zyxin is expressed at very low levels and remains diffusely distributed throughout the cytoplasm, instead of concentrating in actin-rich dynamic structures. Zyxin has tumor suppressor activity in Ewing tumor cells. PMID: 15748890
    25. zyxin indirectly enables the interaction of ZNF384/CIZ/NMP4 with p130CAS PMID: 16510139
    26. A sarch for genes upregulated by thymosin beta4 identified zyxin in SiHA cells in the presence of exogenously added thymosin beta4 and when thymosin beta4 is overexpressed using adenoviral vectors. PMID: 16956606
    27. These results suggest that zyxin is involved in mechanical-force-dependent facilitation of actin polymerization at focal adhesions. PMID: 18682496
    28. We identified zyxin as an interactor with endoglin in human umbilical vein vascular endothelial cells and this interaction is localized within the 47-amino acid carboxyl-terminal cytosolic domain of endoglin, and maps within zyxin residues 326-572. PMID: 15084601

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.
  • 蛋白家族：
    Zyxin/ajuba family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13200

    OMIM: 602002

    KEGG: hsa:7791

    STRING: 9606.ENSP00000324422

    UniGene: Hs.490415



主站蜘蛛池模板： 十八禁真人啪啪免费网站| 精品日本一区二区三区在线观看| 国产免国产免费| 日韩精品无码免费专区网站| 国产肉丝袜视频在线观看| 亚洲日韩av无码| 老熟妇仑乱视频一区二区| 中文字幕人妻无码专区| 无码被窝影院午夜看片爽爽jk| 好吊妞人成视频在线观看27du| 性xxxx搡xxxxx搡欧美| 国产精品被窝福利一区| 国产美熟女乱又伦av果冻传媒| 特黄aaaaaaa片免费视频| 亚洲精品亚洲人成人网| 超清无码av最大网站| 久久理论片午夜琪琪电影院| 国产精品久久久久影院老司| 无码免费无线观看在线视频| 18禁黄网站禁片免费观看不卡| 国产亚洲人成网站在线观看| 亚洲五月天综合| 男女下面进入的视频| 五月丁香啪啪激情综合色九色| 天堂在线.www天堂在线资源| 精品无码国产一区二区三区51安 | 国产欧美精品一区二区三区| 色悠久久久久久久综合网伊人| 亚洲国产精品13p| 久久天天躁狠狠躁夜夜躁app| 黑人巨大精品欧美黑寡妇| 国产a国产片国产| 国产交换配乱婬视频偷网站| 国产又黄又爽又色的免费视频| 竹菊影视欧美日韩一区二区三区四区五区 | 中文字幕无码精品亚洲资源网久久| 国产日产亚洲系列最新| 国产熟妇疯狂4p交在线播放| 999国内精品永久免费观看| 免费无码又爽又高潮视频| 日本无遮挡真人祼交视频|