在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. TCP1 Recombinant Monoclonal Antibody

TCP1 Recombinant Monoclonal Antibody

  • 中文名稱：
    TCP1 Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA056950A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Immunofluorescence staining of Hela cell with CSB-RA056950A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Overlay Peak curve showing jurkat cells stained with CSB-RA056950A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    TCP1
  • 別名：
    T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha), TCP1, CCT1 CCTA
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide from human TCP1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    20F10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IF, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
  • 基因功能參考文獻(xiàn)：
    1. Chaperonin CCT interferes with fibre assembly by interaction of its CCTzeta and CCTgamma subunits with the A53T central hydrophobic region. This interaction is specific to NAC conformation, as it is produced once soluble alpha-synuclein A53T oligomers form and blocks the reaction before fibres begin to grow. PMID: 28102321
    2. chaperonin-containing TCP-1 complex required for lysosomal functioning and autophagosome degradation PMID: 27929117
    3. Result suggest the positive correlation between purinergic receptor P2X 7 (P2X7R) and T-complex protein 1 (TCP-1) in lymphoma patients. PMID: 26556873
    4. Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1-ETO/RUNX1-RUNX1T1 is facilitated by interaction with the chaperonin TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70). PMID: 26706127
    5. Changes for CRMP2, TCP1epsilon, TPM2 and 14-3-3gamma were confirmed in experimental tumors and in a series of 28 human SI-NETs. PMID: 25224486
    6. A role for the TRiC subunits TCP1 and CCT2, and potentially the entire TRiC complex, in breast cancer. PMID: 25704758
    7. CCT8 might be an oncogene and participate in HCC cell proliferation. PMID: 24862099
    8. identified 6 of the 8 components of the chaperonin-containing TCP-1 (CCT) complex bound to LOX-1 cytoplasmic domain PMID: 24846140
    9. Data suggest that specific molecular mediators involved in glucocerebrosidase maturation and degradation, and abnormal interaction with TCP1 and c-Cbl, could be responsible for phenotypic variation among patients with the same genotypes. PMID: 21098288
    10. the membrane binding domain of CTP:phosphocholine cytidylyltransferase has a role in alveolar type II cells PMID: 19684306
    11. Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1. PMID: 11771755
    12. TRiC chaperonin binds to HIF prolyl hydroxylase PHD3 PMID: 15251459
    13. the strong inhibitory action of PhLP(S) on Gbetagamma signaling is the result of a previously unrecognized mechanism of Gbetagamma-regulation, inhibition of Gbetagamma-folding by interference with TCP-1alpha PMID: 15745879
    14. Data show that Plk1 associates with chaperonin-containing TCP1 complex (CCT) both in vitro and in vivo. PMID: 15923617
    15. The specific and directed rearrangement of the beta-actin structure, seen in the natural beta-actin-TRiC system, is vital for guiding beta-actin to the native state. PMID: 17939680
    16. a paper describing a pathway in which this gene product functions PMID: 1630491

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    TCP-1 chaperonin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11655

    OMIM: 186980

    KEGG: hsa:6950

    STRING: 9606.ENSP00000317334

    UniGene: Hs.363137



主站蜘蛛池模板： 国产高清在线精品一区| 国产suv精品一区二区五| 老太婆性杂交视频| 精品精品国产男人的天堂| 无码高潮喷吹在线观看| 成人国产一区二区三区精品| 国产成人精品免高潮在线观看| 又色又爽又高潮免费视频观看| 狠狠色噜噜狠狠狠888米奇视频| 天堂а√在线官网| 亚洲国产欧美在线人成人| 中文字幕av无码免费久久| 人妻互换一二三区激情视频| 亚洲成a人v影院色老汉影院| 无码国产欧美一区二区三区不卡| 热99re久久精品国产首页免费| 欧美肥臀大屁股magnet| 国产欧美日韩va另类在线播放| 亚洲狠狠婷婷综合久久| 日本少妇被黑人xxxxx| 少妇夜夜春夜夜爽试看视频| 色噜噜噜亚洲男人的天堂| 一二三四区无产乱码1000集 | 久久超碰精品一夜七次郎| 97久久超碰精品视觉盛宴| 久久精品无码一区二区www| 黑人巨大精品欧美| 亚洲人成色4444在线观看| 人人模人人爽人人喊久久| 亚洲欧美中文字幕日韩一区二区| 亚洲精品无码久久| 中文精品无码中文字幕无码专区| 成在人线av无码免观看| 西西艺术人像摄影| 国产乱人伦精品一区二区在线观看| 人妻熟妇乱又伦精品视频中文字幕| 久久精品人妻一区二区三区| 四虎成人欧美精品在永久在线| 国产裸体xxxx视频| 999zyz玖玖资源站永久| 日本两人免费观看的视频|