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SOCS7 Recombinant Monoclonal Antibody

  • 中文名稱：
    SOCS7重組抗體
  • 貨號：
    CSB-RA594821A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA594821A0HU diluted at 1:50 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.43% DAB.
    • Overlay Peak curve showing HepG2 cells stained with CSB-RA594821A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA594821A0HU 重組單克隆抗體是針對SOCS7蛋白開發(fā)的高特異性科研工具。SOCS7作為細(xì)胞因子信號抑制因子家族成員，通過調(diào)控JAK-STAT信號通路參與免疫應(yīng)答、細(xì)胞周期調(diào)控及代謝平衡等生物學(xué)過程。本抗體經(jīng)ELISA、免疫組化（IHC）和流式細(xì)胞術(shù)（FC）多平臺驗(yàn)證，在推薦稀釋比例（IHC 1:50-1:200，F(xiàn)C 1:50-1:200）下展現(xiàn)出優(yōu)異的目標(biāo)蛋白結(jié)合能力，可精準(zhǔn)識別天然構(gòu)象及變性狀態(tài)的SOCS7，實(shí)驗(yàn)結(jié)果具有高重復(fù)性與低背景干擾特性。其應(yīng)用涵蓋體外細(xì)胞模型、組織切片及原代細(xì)胞分析，適用于探究SOCS7在炎癥反應(yīng)、腫瘤微環(huán)境調(diào)控或代謝性疾病中的分子機(jī)制研究，為信號轉(zhuǎn)導(dǎo)通路解析、蛋白質(zhì)相互作用分析及疾病相關(guān)生物標(biāo)記物檢測提供可靠工具。本產(chǎn)品嚴(yán)格遵循質(zhì)量控制標(biāo)準(zhǔn)，適用于基礎(chǔ)科研領(lǐng)域的蛋白表達(dá)定位及功能研究。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and phospholipase C gamma-binding protein) (Nck-associated protein 4) (NAP-4), SOCS7, NAP4 SOCS6
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human SOCS7
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    23E4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • 基因功能參考文獻(xiàn)：
    1. This study showed that increased protein levels of SOCS-4 and SOCS-7 in Alzheimer's disease brains. PMID: 25286386
    2. This SOCS7 knockdown-attributed effect could be due to a precise anti-PLCg-1 role. PMID: 25162020
    3. genetic variants in the SOCS7 gene do not impact variation in glucose homeostasis traits and only minimally impact risk of T2DM in the Old Order Amish PMID: 23767996
    4. Insulin Like Growth Factor I treatment and SOCS7 loss have synergistically resulted in increased growth and migration of MCF7 and in increased migration of MDA-MB-231 cells. PMID: 24046004
    5. The present report describes for the first time associations between common variants in SOCS7 gene and obesity, central obesity, insulin resistance and disorders of lipid metabolism in nondiabetic men from Argentina. PMID: 22397880
    6. SOCS7 functioned as an oncogene, the finding that revealed a novel mechanism of carcinogenesis in bladder cancer cells. PMID: 23392170
    7. LNCaP-S17 cells are resistant to exogenous IL-6-induced neuroendocrine differentiation due to increased levels of CIS/SOCS7 that block activation of JAK2-STAT3 pathways. PMID: 22213096
    8. Higher mRNA expression levels of SOCS1, 3, 4 and 7 are significantly associated with earlier tumour stage and better clinical outcome in human breast cancer. PMID: 20433750
    9. findings show that PPAR-gamma is involved in the regulation of SOCS-7 expression by hepatitis C virus core protein genotype 3a PMID: 20357037
    10. Taken together, our data indicate that SOCS-7 interacts with vinexin and the actin cytoskeleton. PMID: 15242778
    11. Results indicate that SOCS-7 is a dysregulator of prolactin, leptin, and growth hormone signaling and that its mode of action is a variation of SOCS protein inhibition of cytokine-inducible STAT3 and 5-mediated signal transduction. PMID: 15677474
    12. data suggest that SOCS7 is a potent regulator of glucose homeostasis and insulin signaling PMID: 16127460

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
  • 組織特異性：
    Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29846

    OMIM: 608788

    KEGG: hsa:30837

    STRING: 9606.ENSP00000464034

    UniGene: Hs.514132



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