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  4. SMARCC1 Recombinant Monoclonal Antibody

SMARCC1 Recombinant Monoclonal Antibody

  • 中文名稱：
    SMARCC1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA290732A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of SMARCC1 expression in HepG2 cells using SMARCC1 antibody. Green, isotype control; red, SMARCC1.
    • Immunocytochemical staining of HepG2 cells with SMARCC1 antibody. Nuclei were stained blue with DAPI; SMARCC1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using SMARCC1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with SMARCC1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SMARCC1
  • 別名：
    SMARCC1; SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin Subfamily C Member 1; BAF155; CRACC1; SRG3; SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily C Member 1; SWI/SNF Complex Subunit SMARCC1; SWI/SNF Complex 155 KDa Subunit; BRG1-Associated Factor 155; Rsc8; SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of; Chromatin, Subfamily C, Member 1; Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 155; Chromatin Remodeling Complex BAF155 Subunit; HYC5; SWI3; RSC8
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human SMARCC1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    25E5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
  • 基因功能參考文獻：
    1. Study found SMARCC1 as a direct target of miR-202-5p and promoted the growth and metastasis of colorectal carcinoma (CRC) cells. Furthermore, SMARCC1 could reverse the inhibitory effect of miR-202-5p on growth and metastasis of CRC cells. PMID: 30144500
    2. our data showed that Swi3 strongly affects haem/oxygen-dependent activation of respiration gene promoters whereas Swi2 affects only the basal, haem-independent activities of these promoters. using computational analysis and RNAi knockdown, we showed that the mammalian Swi3 BAF155 and BAF170 regulate respiration in HeLa cells. PMID: 27190130
    3. Results show the secondary structure of SWIRM domain of BAF155 consists of five alpha-helices forming a typical histone fold for DNA interactions. PMID: 23996527
    4. we identify BAF155 as a substrate for arginine methyltransferase CARM1. PMID: 24434208
    5. Wwp2 acts as a ubiquitin ligase of SRG3. PMID: 24365151
    6. miR-320c regulates the resistance of pancreatic cancer cells to gemcitabine through SMARCC1. PMID: 23799850
    7. loss of BAF155 expression represents another mechanism for inactivation of SWI/SNF complex activity in the development in human cancer. PMID: 22139574
    8. Data show that the mechanism of BAF155-mediated stabilization of BAF57 involves blocking its ubiquitination by preventing interaction with TRIP12. PMID: 20829358
    9. protein levels of BAF155/170 dictate the maximum cellular amount of BAF57 PMID: 16199878
    10. Constitutive expression of SRG3 inhibits positive selection processes in T-cell receptor transgenic mice. PMID: 17513758
    11. An increased expression of SMARCC1 protein was found in prostate cancer positively correlated with tumour dedifferentiation, progression, metastasis and time to recurrence. PMID: 18581278
    12. patients with tumours displaying high levels of CBFB and SMARCC1 proteins had a significantly better overall survival rate than patients with low levels PMID: 19156145

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    SMARCC family
  • 組織特異性：
    Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 11104

    OMIM: 601732

    KEGG: hsa:6599

    STRING: 9606.ENSP00000254480

    UniGene: Hs.476179



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