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RAP1GAP Recombinant Monoclonal Antibody

  • 中文名稱:
    RAP1GAP Recombinant Monoclonal Antibody
  • 貨號:
    CSB-RA559749A0HU
  • 規(guī)格:
    ¥1320
  • 圖片:
    • Overlay Peak curve showing PC-3 cells stained with CSB-RA559749A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    KIAA0474 antibody; Rap1 GTPase activating protein 1 antibody; RAP1 GTPase activating protein antibody; Rap1 GTPase-activating protein 1 antibody; RAP1GA1 antibody; Rap1ga1 protein antibody; Rap1GAP antibody; Rap1GAP1 antibody; RAP1GAPII antibody; RAPGAP antibody; RPGP1_HUMAN antibody
  • 反應種屬:
    Human
  • 免疫原:
    A synthesized peptide derived from human RAP1GAP
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    12C12
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA, FC
  • 推薦稀釋比:
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
  • 基因功能參考文獻:
    1. This is the first mechanistic study of Rap1Gap in breast cancer progression. Decreases in Rap1Gap expression led to changes in adherens junctions via reduction in E-cadherin levels, to cytoskeletal remodeling, and to increases in ERK activation that are correlated with an invasive phenotype in DCIS PMID: 30144784
    2. Rap1GAP may play a significant role in gastric cancer progression and act as a valuable prognostic marker for gastric cancer. PMID: 29758923
    3. results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity PMID: 27612188
    4. Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC). PMID: 28196746
    5. Rap1GAP is ubiquitinated and degraded through proteasome pathway in mitosis. Rap1GAP interacts with PLK1 in vivo. PMID: 25329897
    6. kidney biopsies from glomerulosclerosis patients exhibited increased RAP1GAP, resulting in diminished glomerular RAP1 activation PMID: 24642466
    7. findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells. PMID: 23864657
    8. Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro. PMID: 22614916
    9. Downregulation of RAP1GAP in thyroid tumors enhances SRC-dependent signals that regulate cellular architecture and motility. PMID: 22696507
    10. Over-expression of Rap1GAP attenuated levels of both cadherins and integrins that are known to regulate the cancer cells invasion in renal cel carcinoma. PMID: 22266190
    11. Rap1GAP is a more effective inhibitor of cell-matrix adhesion compared to cell-cell adhesion. PMID: 21785277
    12. A polycomb-mediated repression of rap1GAP was demonstrated that involves EZH2, a histone methyltransferase in head and neck cancers. It was also shown that the loss of miR-101 expression correlates with EZH2 upregulation and rap1GAP downregulation. PMID: 21532618
    13. These studies establish that the direct physical interaction of Rap1 with KRIT1 enables the translocation of microtubule-sequestered KRIT1 to junctions, thereby supporting junctional integrity and cardiovascular development PMID: 21633110
    14. The expression level of RAP1GAp in myelodysplastic syndrome patients significantly increased as compared with patients with non-malignant blood diseases or AML. PMID: 19549374
    15. Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities PMID: 21460216
    16. Results suggest that downregulation of Rap1GAP in epithelial tumors where alterations in cell/cell and cell/matrix adhesion are early steps in tumor dissemination supports a role for Rap1GAP depletion in tumor progression. PMID: 20439492
    17. Epigenetic or genetic loss of Rap1GAP is very common in thyroid cancer, where these events are sufficient to promote cell proliferation and invasion. PMID: 20124489
    18. Rap1GAP protein levels are tightly regulated and it may have a role as a tumor suppressor PMID: 14660640
    19. data identify rap1GAP as a putative tumor suppressor gene in pancreatic cancer PMID: 16424023
    20. Down-regulation of Rap1GAP is associated with oropharyngeal squamous cell carcinoma PMID: 16436672
    21. Data implicate Rap1GAP as a putative tumor/invasion suppressor in the thyroid, and show that downregulation of Rap1GAP contributes to Ras transformation. PMID: 17646383
    22. Rap1 increases KRIT-1 targeting to endothelial cell-cell junctions where it suppresses stress fibers and stabilizes junctional integrity. PMID: 17954608
    23. Rap1GAP inhibits tumor growth but induces MMP2- and MMP9-mediated SCC invasion and tumor progression, suggesting a role for this protein as a biomarker for early N-stage, aggressive SCCs PMID: 18483282
    24. Data propose that over-expression of RAP1GAP gene may play a role in the pathogenesis of myelodysplastic syndrome. PMID: 18551404
    25. a role for Rap1GAP depletion in the progression of human thyroid tumors, possibly through unrestrained Rap activity. PMID: 19066305
    26. Overexpression of Rap1GAP in melanoma cells blocks Rap1 activation and extracellular signal-regulated kinase (ERK) phosphorylation and inhibits melanoma cell proliferation and survival. PMID: 19147557
    27. model in which the Ras GAP-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1, allowing stabilization of the transition state during GTP hydrolysis initiated by the arginine finger PMID: 19433443

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  • 亞細胞定位:
    Golgi apparatus membrane; Peripheral membrane protein.
  • 組織特異性:
    Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 9858

    OMIM: 600278

    KEGG: hsa:5909

    STRING: 9606.ENSP00000290101

    UniGene: Hs.148178



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