在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. PSMC5 Recombinant Monoclonal Antibody

PSMC5 Recombinant Monoclonal Antibody

  • 中文名稱：
    PSMC5 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA879024A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: PC-3 whole cell lysate(20μg),HepG2 whole cell lysate(20μg), Jurkat whole cell lysate(20μg), U-251MG whole cell lysate(20μg),A549 whole cell lysate(20μg),MCF-7 whole cell lysate(20μg),HEK293 whole cell lysate(20μg),Mouse brain tissue lysate(20μg),Rat brain tissue lysate(20μg)
      All lanes: PSMC5 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 46 kDa
      Observed band size: 50 kDa
      Exposure time：1min
    • Immunofluorescence staining of Hela cell with CSB-RA879024A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Overlay Peak curve showing SH-SY5Y cells stained with CSB-RA879024A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PSMC5
  • 別名：
    26S protease regulatory subunit 8 antibody; 26S proteasome AAA-ATPase subunit RPT6 antibody; Cim3 antibody; MSUG1 protein antibody; p45 antibody; p45/SUG antibody; Proteasome 26S ATPase subunit 5 antibody; Proteasome 26S subunit ATPase 5 antibody; Proteasome prosome macropain 26S subunit ATPase 5 antibody; Proteasome subunit p45 antibody; PRS8_HUMAN antibody; PSMC5 antibody; Rpt6 antibody; S8 antibody; SUG1 antibody; Tat binding protein homolog 10 antibody; TBP10 antibody; Thyroid hormone receptor interacting protein 1 antibody; Thyroid hormone receptor-interacting protein 1 antibody; Thyroid receptor interactor 1 antibody; TRIP1 antibody; TRIP1(SUG1) antibody
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    A synthesized peptide derived from human PSMC5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    4E5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
  • 基因功能參考文獻：
    1. autoinflammation-associated H443P nlrc4 mutant is altered in interaction with SUG1 and ubiquitinated proteins, triggering constitutive caspase-8-mediated cell death dependent on FADD but independent of Ser(533) phosphorylation. PMID: 27974463
    2. Our data suggest that PSMC5 facilitates the damaging effects of radiation in radiation-responsive H460 cancer cells and therefore may serve as a prognostic indicator for radiotherapy and molecular targeted therapy in lung cancer patients. PMID: 26592665
    3. XopJ has protease activity to specifically degrade RPT6. PMID: 25739698
    4. TRIP-1 regulates fibroblast acquisition of phenotype and function associated with myofibroblasts. PMID: 24528651
    5. gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity PMID: 24482233
    6. Rpt6 interacts directly with CKIP-1 and promotes the turnover of Smurf1. PMID: 23032291
    7. Sug1 plays a critical role in transcription of MHC class I, and the MHC class II-like molecules, HLA-DM and HLA-DO. PMID: 22771340
    8. Findings show that Sug1 is crucial for regulating histone H3K4me3 and H3R17me2 at the cytokine inducible MHC-II and CIITA promoters. PMID: 19660582
    9. SUG1 has a role in ubiquitin/proteasome-mediated degradation of estrogen receptors PMID: 14702340
    10. Proteasome dysfunction by a proteasome inhibitor or siRNA-mediated knock-down of Sug1 caused the up-regulation of MYO18B protein and MYO18B was polyubiquitinated in vivo. PMID: 16499872
    11. p45 plays an important role in regulating ataxin-3 degradation by the proteasome. PMID: 17302910
    12. These data demonstrate that both 19S and 20S subunits of the 26S proteasome play specific and critical roles in regulating CIITA activity and MHC class II transcription. PMID: 18215421
    13. The current study strongly implicates the 19S ATPase Sug1 in modifying histones to initiate major histocompatibility complex class II transcription and provides novel insights into the role of the proteasome in the regulation of mammalian transcription. PMID: 18662994
    14. SUG-1 has a unique role in linking the transcription and degradation processes via its ability to interact with SRC-3. PMID: 19144644

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    AAA ATPase family
  • 數據庫鏈接：

    HGNC: 9552

    OMIM: 601681

    KEGG: hsa:5705

    STRING: 9606.ENSP00000310572

    UniGene: Hs.79387



主站蜘蛛池模板： 国产精品va在线观看无码| 欧美黑人与白人精品a片| 日韩在线一区二区三区免费视频| 亚洲日韩高清在线亚洲专区| 电影久久久久久| 免费播放婬乱男女婬视频国产 | 久久精品国产欧美日韩| 人妻中文字幕av无码专区| 中文无码字幕中文有码字幕| av无码中文字幕不卡一区二区三区 | 真实国产乱子伦对白视频不卡| 激情综合亚洲色婷婷五月| 任我橹这里只有精品 在线视频| 欧美人妻少妇精品久久黑人| 天天爱天天做狠狠久久做| 成人片黄网站a毛片免费| 黑人巨茎大战欧美白妇免费| 欧美日韩亚洲tv不卡久久| 免费无码又爽又刺激毛片| 成人毛片18女人毛片免费| 熟妇的味道hd中文字幕| 国产v综合v亚洲欧美久久| 2021国产精品香蕉在线观看| 热久久视久久精品18| 18禁在线永久免费观看| 男ji大巴进入女人的视频小说| 日本熟妇浓密毛毛多| 欧洲国产精品无码专区影院| 亚洲va中文字幕无码毛片| 精品夜夜爽欧美毛片视频 | 90后极品粉嫩小泬20p| 久久久噜噜噜久噜久久| 女性自慰网站免费观看w| 亚洲成 人 综合 亚洲欧洲| av天堂午夜精品一区| 日本三级成本人网站| 肉感饱满中年熟妇日本| 亚洲人成小说网站色在线观看| 国产热re99久久6国产精品首页| 丰满人妻被中出中文字幕| 久章草国语自产拍在线观看|