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  4. PPP2R5D Recombinant Monoclonal Antibody

PPP2R5D Recombinant Monoclonal Antibody

  • 中文名稱：
    PPP2R5D Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA439668A0HU
  • 規格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA439668A0HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA439668A0HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing Hela cells stained with CSB-RA439668A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    2A5D_HUMAN antibody; B'delta antibody; B56D antibody; Delta isoform of regulatory subunit B56; protein phosphatase 2A antibody; MGC2134 antibody; MGC8949 antibody; OTTHUMP00000039821 antibody; PP2A B subunit B' delta isoform antibody; PP2A B subunit B56 delta isoform antibody; PP2A B subunit isoform B''-delta antibody; PP2A B subunit isoform B56-delta antibody; PP2A B subunit isoform PR61-delta antibody; PP2A B subunit isoform R5-delta antibody; PP2A B subunit PR61 delta isoform antibody; PP2A B subunit R5 delta isoform antibody; PPP2R5D antibody; Protein phosphatase 2 regulatory subunit B (B56) delta isoform antibody; Protein phosphatase 2 regulatory subunit B delta isoform antibody; Protein phosphatase 2 regulatory subunit B' delta antibody; Serine threonine protein phosphatase 2A 56 kDa regulatory subunit delta isoform antibody; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform antibody; TEG-271 antibody; Tex271 antibody
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human PPP2R5D
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    18C3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
  • 基因功能參考文獻：
    1. Mutations in PPP2R5D are genetic cause of intellectual disability. PMID: 26576547
    2. MiR-9 regulates GR signaling and steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity. PMID: 25772595
    3. Mutant B56delta was A and C binding-deficient, while mutant Aalpha subunits bound B56delta well but were unable to bind C PMID: 26168268
    4. PP2A-B56delta is the single most significant contributor, of the PP2A holoenzyme subunits, to BubR1 and Bub1 kinetochore localization. PMID: 25246613
    5. Protein kinase A mediated activation of protein phosphatase 2A is enabled by PPP2R5D phosphorylation, which modulates the affinity of the protein phosphatase 2A holoenzyme to its physiological substrates. PMID: 20423611
    6. Data show that the protein phosphatase 2A subunit B56delta specifically interacts with HAND1 and -2, but not other basic helix-loop-helix proteins. PMID: 14636580
    7. Gonadotropin-releasing hormone (GnRH) affects the membrane protein phosphatase 2A-associated apoptosis and the enzyme activity in ovarian cancer cells. PMID: 15809743
    8. PP2A:B56delta as a key upstream regulator of Cdk1 activity upon exit from mitosis PMID: 18056802

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  • 相關疾病：
    Mental retardation, autosomal dominant 35 (MRD35)
  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.
  • 蛋白家族：
    Phosphatase 2A regulatory subunit B56 family
  • 組織特異性：
    Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.
  • 數據庫鏈接：

    HGNC: 9312

    OMIM: 601646

    KEGG: hsa:5528

    STRING: 9606.ENSP00000417963

    UniGene: Hs.533308



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