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  4. PPM1G Recombinant Monoclonal Antibody

PPM1G Recombinant Monoclonal Antibody

  • 中文名稱：
    PPM1G Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA213346A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA213346A0HU diluted at 1:100 and staining in paraffin-embedded human colorectal cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing Hela cells stained with CSB-RA213346A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PPM1G
  • 別名：
    Protein phosphatase 1G (EC 3.1.3.16) (Protein phosphatase 1C) (Protein phosphatase 2C isoform gamma) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma), PPM1G, PPM1C
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide from human PPM1G protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    5E2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻：
    1. PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP. PMID: 26324325
    2. Hypermethylation in the 3'-protein-phosphatase-1G (PPM1G) gene locus was associated with alcohol use disorder. PMID: 25982659
    3. PPM1G inactivates monomeric WWP2 and promotes the assembly of WWP2-WWP1 heterodimeric complex. PMID: 25071155
    4. PPM1G dephosphorylates the P-TEFb kinase T loop to disassemble the 7SK snRNP. PMID: 24316072
    5. study has identified protein phosphatase PPM1G as a novel regulator of cap-dependent protein translation by negatively controlling the phosphorylation of 4E-BP1. PMID: 23814053
    6. ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage PMID: 22361354
    7. The degradation of p21(WAF1/CIP1) induced by PP2Cgamma was mediated in a proteasome-dependent manner. PMID: 17054950
    8. Protein phosphatase 2C gamma mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes. PMID: 17074886
    9. PP2Cgamma modulates alternative splicing of specific pre-mRNAs coregulated by YB-1. PMID: 17572683
    10. an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex PMID: 17984321
    11. PP2Cgamma is a novel regulator of p21(Cip1/WAF1) protein stability via the Akt signaling pathway. PMID: 19538940
    12. Functional study of the mouse homolog PMID: 9271424

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  • 亞細胞定位：
    Cytoplasm. Membrane; Lipid-anchor.
  • 蛋白家族：
    PP2C family
  • 組織特異性：
    Widely expressed. Most abundant in testis, skeletal muscle, and heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9278

    OMIM: 605119

    KEGG: hsa:5496

    STRING: 9606.ENSP00000264714

    UniGene: Hs.643951



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