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MUC17 Recombinant Monoclonal Antibody

  • 中文名稱(chēng)：
    MUC17重組抗體
  • 貨號(hào)：
    CSB-RA727848MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human MUC17 with Anti-MUC17 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MUC17 (CSB-MP727848HU) at 2 μg/mL can bind Anti-MUC17 recombinant antibody. The EC50 is 0.9057-1.259 ng/mL.
    • The purity of MUC17 was greater than 95% as determined by SEC-HPLC
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA727848MA1HU MUC17重組單克隆抗體是經(jīng)ELISA驗(yàn)證的高特異性科研工具，靶向黏蛋白家族成員MUC17。該跨膜糖蛋白在胃腸道上皮屏障保護(hù)和細(xì)胞信號(hào)調(diào)控中發(fā)揮重要作用，其異常表達(dá)與消化系統(tǒng)病理過(guò)程密切相關(guān)。本抗體通過(guò)重組技術(shù)制備，具備優(yōu)異的重現(xiàn)性和批次穩(wěn)定性，適用于定量ELISA檢測(cè)體系，可精準(zhǔn)識(shí)別天然構(gòu)象的MUC17蛋白。實(shí)驗(yàn)數(shù)據(jù)顯示其在抗原識(shí)別中展現(xiàn)高親和力與低交叉反應(yīng)性，能夠有效支持基礎(chǔ)研究中的蛋白表達(dá)水平分析、病理機(jī)制探索及相關(guān)信號(hào)通路研究。該產(chǎn)品特別適用于胃腸道疾病模型構(gòu)建、腫瘤微環(huán)境分析以及黏蛋白功能組學(xué)研究，為探討MUC17在細(xì)胞黏附、分化及免疫調(diào)節(jié)中的作用提供可靠檢測(cè)工具，滿足分子互作研究和生物標(biāo)志物篩選等科研需求。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Mucin-17, MUC-17, Small intestinal mucin-3 (MUC-3), MUC17, MUC3
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human MUC17 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 抗體亞型：
    Human IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    8D12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Probably plays a role in maintaining homeostasis on mucosal surfaces.
  • 基因功能參考文獻(xiàn)：
    1. MUC17 polymorphisms are involved in endometriosis development and the associated infertility in the Taiwanese population. PMID: 26285705
    2. Carbachol stimulated enterocyte MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment. PMID: 23784542
    3. The HIF1alpha-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of hypoxia responsive element could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells. PMID: 22970168
    4. Both native and exogenous MUC17 play a role in attachment and invasion of enteroinvasive E. coli in colonic cell lines and in maintaining epithelial barrier function. PMID: 21393431
    5. Hypomethylation status in the MUC17 promoter could be a novel epigenetic marker for the diagnosis of Pancreatic ductal adenocarcinomas. PMID: 20926598
    6. Results indicate that the potential protective effects of this membrane-bound mucin are primarily or secondarily diminished in inflammatory and neoplastic conditions. PMID: 20702471
    7. augments intestinal cell restitution and enhances healing of experimental colitis in mice PMID: 20211273
    8. The authors demonstrate that apically atypical enteropathogenic Escherichia coli infection is followed by increased production of secreted MUC2 and MUC5AC mucins and membrane-bound MUC3 and MUC4 mucins. PMID: 20065027
    9. sequence homology & chromosome mapping PMID: 11855812
    10. surface localization of the smaller subunit of MUC17 is dependent on its N-glycosylation status PMID: 12888891
    11. The MUC17 sequence has been extended toward its 5'-extremity to complete the sequence and localize the promoter and regulatory elements. PMID: 16737958
    12. Pdzk1 plays a specific role in stabilizing Muc17 in the apical membrane of small intestinal enterocytes. PMID: 17990980

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  • 亞細(xì)胞定位：
    [Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Secreted. Cell membrane.
  • 組織特異性：
    Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in panc
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16800

    OMIM: 608424

    KEGG: hsa:140453

    STRING: 9606.ENSP00000302716

    UniGene: Hs.271819



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