在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. MTA2 Recombinant Monoclonal Antibody

MTA2 Recombinant Monoclonal Antibody

  • 中文名稱：
    MTA2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA568219A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate(30μg), NIH/3T3 whole cell lysate(30μg)
      All lanes: MTA2 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 75 kDa
      Observed band size: 70 kDa
      Exposure time：3min
    • IHC image of CSB-RA568219A0HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA568219A0HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Immunofluorescence staining of A431 cell with CSB-RA568219A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Overlay Peak curve showing jurkat cells stained with CSB-RA568219A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MTA2
  • 別名：
    Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1) (MTA1-L1 protein) (p53 target protein in deacetylase complex), MTA2, MTA1L1 PID
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    A synthesized peptide from human MTA2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    11D11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:50-1:200
    IF 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
  • 基因功能參考文獻：
    1. This study is the first to demonstrate that SNHG5 is a critical and powerful regulator that is involved in GC progression through trapping MTA2 in the cytosol. PMID: 27065326
    2. Taken together with previous findings this suggests, that MTA-RBBP is a stable complex, with a central role in the initial assembly of the human NuRD complex. PMID: 28179136
    3. These results indicated there might be a tight correlation among MTA2, Ki-67 and hepatocellular carcinoma prognosis PMID: 26722504
    4. MTA2 is a crucial biomarker that is closely related with prognosis of colorectal carcinoma and also a potential molecular target for evaluating the prognosis and treatment of CRC. PMID: 26261611
    5. MTA2 overexpression enhances colony formation and tumor growth of gastric cancer cells, but not plays important role in cancer cell migration and metastasis. IL-11 is one of the downstream effectors of MTA2 in regulating gastric cancer cells growth PMID: 25929737
    6. MTA-2 protein may facilitate the invasive potential of non-small-cell lung cancer cells through the inhibition of the cell adhesion molecule Ep-CAM and E-cadherin, suggesting that it might be a potential therapeutic target in NSCLC. PMID: 25969565
    7. High MTA2 protein and mRNA expression is associated with glioma. PMID: 25048531
    8. MTA2 acts as a central hub for cytoskeletal organization and transcription and provides a link between nuclear and cytoskeletal organization. PMID: 25394532
    9. MTA2 depletion could significantly inhibit human breast cancer cell growth and metastasis, implying that MTA2 might be involved in the progression of breast cancer. PMID: 25081667
    10. Study demonstrates that hBD-3 inhibits the progression of colon cancer in a paracrine fashion through downregulation of MTA2 expression. PMID: 24969834
    11. Mta2 and Tipin cooperate to maintain replication fork integrity, especially on regions that are intrinsically difficult to duplicate. PMID: 24830473
    12. MTA2 knockdown impairs invasion and metastasis of gastric cancer cells. PMID: 24010737
    13. results reveal a novel post-translational regulation of MTA2 by the way of p300-dependent acetylation, which is important for tumor cells growth and migration and provides a potential target for clinical cancer research PMID: 24468085
    14. High expression levels of MTA2 is associated with pancreatic ductal adenocarcinoma. PMID: 23400716
    15. MTA2 is highly expressed in the primary lesions of gastric cancer than that in adjacent non-cancerous tissues, and is closely related with tumor invasion. MTA2 expression is elevated in Sp1 positive gastric cancer. PMID: 23158992
    16. Sertoli cell-specific expression of MTA2 is required for transcriptional regulation of FSHR gene during spermatogenesis. PMID: 23086931
    17. High nuclear MTA2 expression is associated with thymoma. PMID: 22833212
    18. Our data suggested that MTA2 might play roles in both the nucleus and cytoplasm in the progression of NSCLC. PMID: 22585429
    19. The expression of MTA2 had positive correlation with clinical stage and lymph node metastasis. PMID: 20704817
    20. interaction with mCpG-binding domain of MBD2 PMID: 12124384
    21. MTA2 is a repressor of estrogen receptor (ER)alpha activity and that it could represent a new therapeutic target of ERalpha action in human breast tumors PMID: 16645043
    22. Findings indicate a tight correlation between the MTA2 expression level and hepatocellular carcinoma size and differentiation. PMID: 19702911
    23. Deacetylation and functional interactions by the PID/MTA2-associated NuRD complex may represent an important pathway to regulate p53 function. PMID: 11099047

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 7411

    OMIM: 603947

    KEGG: hsa:9219

    STRING: 9606.ENSP00000278823

    UniGene: Hs.173043



主站蜘蛛池模板： 狠狠躁夜夜躁人人爽天天 | 人妻少妇精品无码专区app| 动漫av网站免费观看| 狠狠色婷婷久久一区二区三区| 男ji大巴进入女人的视频小说| 国产漂亮白嫩美女在线观看| 亚洲精品伊人久久久大香 | 熟女人妻av粗壮巨龙| 精品午夜福利在线视在亚洲| 久久国产亚洲精选av| 小荡货好紧好爽奶头大视频| 日本不卡高字幕在线2019| 人妻少妇被粗大爽.9797pw| 在线播放免费人成毛片试看| 国产一卡二卡三新区2022| 日韩精品一区二区三区| 性生交大片免费看女人按摩摩| 亚洲 日本 欧美 中文字幕| 亚洲精品一卡2卡三卡4卡 | 再深点灬舒服灬太大了在线视频| 国产男女猛烈无遮挡免费视频| 亚洲18色成人网站www| 午夜a理论片在线播放| 日韩精品无码人成视频| 网禁拗女稀缺资源在线观看| 14萝自慰专用网站| 亚洲国产成人一区二区精品区 | 欧美人成精品网站播放| 国产午夜福利视频在线观看| 精品一区二区三区在线观看视频| 亚洲色大网站www永久网站| 国产精品亚洲а∨无码播放不卡| 精品无码专区毛片| 日日狠狠久久8888偷偷色| 亚洲制服 视频在线观看| 久久国产乱子伦精品免费台湾| 无码精品人妻一区二区三区影院| 亚洲爆乳无码一区二区三区| 国产原创av中文在线观看| 末成年女av片一区二区| 一本一道波多野结衣av一区|