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  4. LYPD3 (Lupartumab) Recombinant Monoclonal Antibody

LYPD3 (Lupartumab) Recombinant Monoclonal Antibody

  • 中文名稱：
    LYPD3 (Lupartumab) Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA013263MA2HU
  • 規格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human LYPD3 with Anti-LYPD3 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA.Immobilized Human LYPD3(CSB-MP013263HU) at 2 μg/mL can bind Anti-LYPD3 recombinant antibody. The EC50 is 2.375-2.905 ng/mL.
    • The Binding Activity of Macaca fascicularit LYPD3 with Anti-LYPD3 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis LYPD3（CSB-MP6357MOV1） at 2 μg/mL can bind Anti-LYPD3 recombinant antibody.The EC50 is 0.8819-1.688 ng/mL.
    • The Binding Activity of Mouse Lypd3 with Anti-LYPD3 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA.Immobilized Mouse Lypd3(CSB-MP849681MO1) at 2 μg/mL can bind Anti-LYPD3 recombinant antibody. The EC50 is 1.995-2.345 ng/mL.
    • The Binding Activity of Rat Lypd3 with Anti-LYPD3 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA.Immobilized Rat Lypd3(CSB-MP013263RA) at 2 μg/mL can bind Anti-LYPD3 recombinant antibody. The EC50 is 3.515-3.992 ng/mL.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    2310061G07Rik antibody; C4.4A antibody; GPI-anchored metastasis-associated protein C4.4A homolog antibody; GPI-anchored metastasis-associated protein homolog antibody; Ly6/PLAUR domain-containing protein 3 antibody; Lypd3 antibody; LYPD3_HUMAN antibody; Matrigel-induced gene C4 protein antibody; MIG-C4 antibody; SHINC3 antibody; Lupartumab
  • 反應種屬：
    Human, Rat, Mouse, Macaca fascicularis
  • 免疫原：
    Recombinant Human LYPD3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    11G8
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:5000-1:50000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
  • 基因功能參考文獻：
    1. While in the healthy liver hepatocytes are C4.4A negative, data show that C4.4A is strongly expressed in hepatocellular carcinoma (HCC) with upregulation at the invasive front and in lung metastasis, indicating that C4.4A apparently contributes to HCC progression. PMID: 29048672
    2. Our results are consistent with previous data in mouse embryogenesis and wound healing. Based on these findings, we conclude that this human TES model provides an excellent surrogate for studies of C4.4A and Haldisin expressions in human stratified epithelia. PMID: 29075641
    3. Expression and crystallographic studies of the D1D2 domains of C4.4A have been reported. PMID: 28777093
    4. LYPD3 has a role in the maintenance of colorectal cancer stem-like cells. PMID: 28238780
    5. Highly expressed C4.4A protein in HER2-positive human breast cancers indicate a good prognosis. PMID: 23918676
    6. overexpression of C4.4A correlates with metastatic potential of gastric cancer and C4.4A could be a novel independent prognostic marker for predicting outcome. PMID: 24935570
    7. expression of the Ly6/uPAR-domain proteins C4.4A and Haldisin in non-invasive and invasive skin lesions PMID: 25414274
    8. Tenascin-C expression was significantly associated with C4.4A expression in clinical esophageal squamous carcinoma samples suggesting that there may be a functional role for the C4.4A to induceTenascin-C in vivo. PMID: 23708783
    9. findings suggest that a tight association between C4.4A and tumor budding may, in part, be due to C4.4A promoting epithelial-mesenchymal transition at the invasive front of colorectal cancer PMID: 22404718
    10. the first explanation for the C4.4A contribution to wound healing and metastasis. PMID: 22431918
    11. data indicate that expression of the C4.4A protein at the invasive front acts as a novel prognostic marker in colorectal cancer, possibly through invasion-related mechanisms PMID: 20825414
    12. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan PMID: 12592373
    13. High tumour cell C4.4A expression is associated with shorter survival for non-small cell lung cancer patients. PMID: 17706320
    14. Overexpression of C4.4A is associated with invasion and metastasis of esophageal squamous cell carcinoma PMID: 17849475
    15. we consider C4.4A as a candidate diagnostic marker in colorectal cancer, which possibly can be detected in body fluids PMID: 17912244
    16. cleavage of C4.4A by ADAM10 and ADAM17 contributes to tumor progression PMID: 18979631

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 組織特異性：
    Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TC
  • 數據庫鏈接：

    HGNC: 24880

    OMIM: 609484

    KEGG: hsa:27076

    STRING: 9606.ENSP00000244333

    UniGene: Hs.631594



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