LDHC Recombinant Monoclonal Antibody
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中文名稱:LDHC重組抗體
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貨號:CSB-RA886298A0HU
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規格:¥1320
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圖片:
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Overlay Peak curve showing Hela cells stained with CSB-RA886298A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
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其他:
產品詳情
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產品描述:CSB-RA886298A0HU LDHC重組單克隆抗體是針對乳酸脫氫酶C亞基(LDHC)開發的高特異性科研試劑。該抗體通過重組蛋白免疫策略制備,經ELISA和流式細胞術(FC)嚴格驗證,在FC應用中推薦使用1:50-1:200稀釋比例。LDHC作為糖酵解關鍵酶,特異性地表達于生殖細胞及多種腫瘤組織,其異常表達與精子活力調控及腫瘤代謝重編程密切相關。本產品能特異性識別天然構象的LDHC蛋白,在FC檢測中展現出優異的信號分辨率和低背景特性,適用于活細胞表面標記及胞內蛋白定位分析。該抗體具有高批次穩定性,可為生殖生物學研究(如精子功能評估)、腫瘤微環境代謝研究(包括腫瘤細胞能量代謝通路解析)以及生殖系統相關疾病機制探索提供可靠工具。其優化的FC性能特別適合用于流式細胞術檢測中低豐度靶標的精準識別,為科研人員開展細胞水平的功能研究提供有效支持。
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Uniprot No.:
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基因名:
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別名:L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X), LDHC, LDH3 LDHX
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反應種屬:Human
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免疫原:A synthesized peptide derived from human LDHC
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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抗體亞型:Rabbit IgG
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純化方式:Affinity-chromatography
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克隆號:9F2
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產品提供形式:Liquid
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應用范圍:ELISA, FC
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推薦稀釋比:
Application Recommended Dilution FC 1:50-1:200 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相關產品
靶點詳情
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功能:Possible role in sperm motility.
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基因功能參考文獻:
- Lactate dehydrogenase C may act as a novel biomarker for renal cell carcinoma progression and a potential therapeutic target for the treatment of renal cell carcinoma. PMID: 28351304
- three uniquely identified proteins (CDK6 , galectin-3-binding protein and LDH C) were found, which show tight connection with prostate cancer and presence of all of them was previously linked to certain aspects of prostate cancer PMID: 26503549
- Down-regulated LDH-C4 expression is significantly correlated with lowered enzyme activity in human spermatozoa. PMID: 25795631
- This is the first report to show a positive correlation between LDH-3 and hemolytic parameters in sickle cell anemia. PMID: 26069337
- LDH3 was increased in essential thrombocythemia. This isoenzymatic pattern could be expression of a metabolic adaptation. PMID: 17178662
- LDH3 is a supporting diagnostic marker in cases of chronic tuberculosis. PMID: 17935709
- hLdhc expression in cancer cells was regulated by transcription factor Sp1 and CREB and promoter CGI methylation PMID: 18930904
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亞細胞定位:Cytoplasm.
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蛋白家族:LDH/MDH superfamily, LDH family
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數據庫鏈接:
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