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KIFAP3 Recombinant Monoclonal Antibody

  • 中文名稱：
    KIFAP3重組抗體
  • 貨號(hào)：
    CSB-RA869779A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate
      All lanes: KIFAP3 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 92, 87, 83 kDa
      Observed band size: 72-95 kDa
    • IHC image of CSB-RA869779A0HU diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Immunofluorescence staining of PC-3 cell with CSB-RA869779A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 552-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA869779A0HU KIFAP3重組單克隆抗體是針對(duì)驅(qū)動(dòng)蛋白家族成員KIFAP3研發(fā)的高特異性科研工具，適用于多種實(shí)驗(yàn)場(chǎng)景。該抗體識(shí)別的靶標(biāo)蛋白KIFAP3在細(xì)胞內(nèi)運(yùn)輸、有絲分裂調(diào)控及纖毛形成中發(fā)揮重要作用，其異常表達(dá)與腫瘤發(fā)生、神經(jīng)退行性疾病密切相關(guān)。經(jīng)嚴(yán)格驗(yàn)證，該抗體在Western Blot中可清晰檢測(cè)目標(biāo)蛋白，免疫組化（IHC）和免疫熒光（IF）實(shí)驗(yàn)顯示其在多種組織與細(xì)胞模型中的特異性定位，推薦使用稀釋度為WB 1:500-1:2000、IHC 1:50-1:200、IF 1:50-1:200，同時(shí)支持ELISA檢測(cè)。其高批次間一致性為細(xì)胞周期研究、胞內(nèi)運(yùn)輸機(jī)制探索及疾病相關(guān)分子網(wǎng)絡(luò)解析提供可靠支持，適用于腫瘤生物學(xué)、神經(jīng)科學(xué)領(lǐng)域的體外實(shí)驗(yàn)及病理模型分析，為研究KIFAP3在細(xì)胞動(dòng)力學(xué)異常或病理微環(huán)境中的功能調(diào)控提供精準(zhǔn)檢測(cè)方案。
  • Uniprot No.：
  • 基因名：
    KIFAP3
  • 別名：
    Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein), KIFAP3, KIF3AP SMAP
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human KIFAP3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    28E9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:50-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex.
  • 基因功能參考文獻(xiàn)：
    1. This study does not show an influence of KIFAP3 variants on survival in the studied Swiss and Swedish cohort PMID: 28140676
    2. Common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. PMID: 24838185
    3. The incidence of the motor neuron-predominant amyotrophic lateral sclerosis phenotype in the patients of this cohort supports the hypothesis that the SNP within the KIFAP3 gene is a potential modifier of the amyotrophic lateral sclerosis phenotype PMID: 21659726
    4. Data clearly show that SNP rs1541160 does not modify survival within cohort of 504 Italian ALS cases. PMID: 20566859
    5. Kinesin-2 plays a role in the KDEL-R-/COPI-dependent retrograde transport pathway from the Golgi complex to the ER. PMID: 17113389
    6. KAP3 sequestration by misfolded SOD1 and the inhibition of ChAT transport play a role in the dysfunction of amyotrophic lateral sclerosis. PMID: 19088126
    7. a variant within the KIFAP3 gene that is associated with decreased KIFAP3 expression and increased survival in sporadic ALS was identified. PMID: 19451621

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  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17060

    OMIM: 601836

    KEGG: hsa:22920

    STRING: 9606.ENSP00000354560

    UniGene: Hs.433442



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