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  4. HPCA Recombinant Monoclonal Antibody

HPCA Recombinant Monoclonal Antibody

  • 中文名稱：
    HPCA Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA828732A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Hippocalcin expression in HepG2 cells using Hippocalcin antibody. Green, isotype control; red, Hippocalcin.
    • Immunocytochemical staining of HepG2 cells with hippocalcin antibody. Nuclei were stained blue with DAPI; Hippocalcin was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
    • Western blotting analysis using Hippocalcin antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Hippocalcin antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    HPCA
  • 別名：
    HPCA; Hippocalcin; Neuron-Specific Calcium-Binding Protein Hippocalcin; Dystonia 2, Torsion (Autosomal Recessive); Calcium-Binding Protein BDR-2; BDR2; DYT2
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human HPCA protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    22G5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases.
  • 基因功能參考文獻：
    1. Sequence analysis of the HPCA gene in 505 patients with dystonia did not reveal variants in the coding regions of HPCA. PMID: 27145302
    2. hippocalcin forms oligomers upon calcium binding and directly interacts with VGCCs. The dystonia-causing mutations did not affect protein stability or folding. In common for both T71N and A190T mutants was an impaired calcium-dependent oligomerisation and increased intracellular calcium influx after KCl depolarisation. PMID: 28398555
    3. None of the patients enrolled was found to carry HPCA mutations, rising suspicion that these probably represent a very rare cause of dystonia in childhood-adolescence. PMID: 27771228
    4. Mutations in HPCA cause autosomal-recessive primary isolated dystonia. PMID: 25799108
    5. analysis of a novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents PMID: 22544757
    6. Hippocalcin is a sensitive Ca2+ sensor capable of responding to increases in intracellular Ca2+ concentration over the narrow dynamic range of 200-800 nM free Ca2+. PMID: 14638856
    7. The structural factors affecting the binding of hippocalcin to phosphatidylinositol 4,5-bisphosphate at the cell surface and the Golgi apparatus are described. PMID: 16053445
    8. Hippocalcin and MLK2 were colocalized in the halo of Lewy bodies in Parkinson disease patients, and neither protein was detected in normal pigmented neurons. PMID: 19332348
    9. diminished hippocalcin expression does not contribute to Huntington disease-related neurodegeneration PMID: 19686238

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  • 相關疾病：
    Dystonia 2, torsion, autosomal recessive (DYT2)
  • 亞細胞定位：
    Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Recoverin family
  • 組織特異性：
    Brain specific.
  • 數據庫鏈接：

    HGNC: 5144

    OMIM: 142622

    KEGG: hsa:3208

    STRING: 9606.ENSP00000362566

    UniGene: Hs.632391



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