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  4. HDGF Recombinant Monoclonal Antibody

HDGF Recombinant Monoclonal Antibody

  • 中文名稱：
    HDGF Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA065054A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in:SH-SY5Y whole cell lysate(30μg)
      All lanes:HDGF antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Observed band size: 37 kDa
      Exposure time：2min
    • Immunofluorescence staining of Hela cell with CSB-RA065054A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Overlay Peak curve showing MCF-7 cells stained with CSB-RA065054A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    HDGF
  • 別名：
    Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2), HDGF, HMG1L2
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide from human HDGF protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    4C2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a transcriptional repressor. Has mitogenic activity for fibroblasts. Heparin-binding protein.; Does not have mitogenic activity for fibroblasts. Does not bind heparin.; Has mitogenic activity for fibroblasts. Heparin-binding protein.
  • 基因功能參考文獻：
    1. miR139 was downregulated in epithelial ovarian cancer, and acted as a tumor suppressor by directly targeting HDGF. PMID: 28713954
    2. high serum levels of HDGF were significantly correlated to bone metastasis and poorer prognosis of non-small cell lung cancer. PMID: 28592712
    3. Data suggested that HDGF knockdown inhibits cellular migration and invasion in vitro of prostate cancer via modulating epithelial-mesenchymal transition signaling pathway, as well as MMP2 and MMP9 signaling pathway. These results supported that HDGF is a relevant protein in the progression of prostate cancer and may serve as a potentially therapeutic target for prostate cancer as well as its downstream targets. PMID: 29300772
    4. HDGF is overexpressed in both androgen-sensitive and androgen-insensitive cell lines. Forced overexpression enhanced cell viability but knockdown reduced proliferation of benign prostate cells.Ectopic HDGF overexpression of HDGF in up-regulated cyclin E and BCL-2, but down-regulated BAX. Treatment with a HDGF monoclonal antibody and vitamin K2 reduced proliferation and inhibited NF-kB expression in a tumor cell line. PMID: 27692835
    5. functional diversity of HDGF isoforms PMID: 27926477
    6. our findings first indicate that the interaction of HDGF and beta-catenin may play a crucial role in tumorigenesis of synovial sarcoma. PMID: 26842923
    7. HDGF was overexpressed in hepatocellular carcinoma patients and cells. PMID: 27273265
    8. miRNA497 directly targets hepatomaderived growth factor (HDGF) in prostate cancer cells. PMID: 26780929
    9. describe two previously unknown HDGF isoforms, HDGF-B and HDGF-C, generated via alternative splicing with structurally unrelated N-terminal regions of their hath region PMID: 26845719
    10. study uncovers a novel function of HDGF as a messenger of cellular condition (alarmin) which in-turn modulates cellular function-aspects that could be used as a biomarker for ovarian cancer. PMID: 26612514
    11. HDGF and beta-catenin interact as a positive feedback loop, which plays an important role in carcinogenesis and progression of colorectal carcinoma. PMID: 26296979
    12. HDGF is important in promoting malignant biological behaviors, including proliferation, migration and invasion of hilar cholangiocarcinoma cells. PMID: 26081074
    13. Hepatoma-derived growth factor overexpression is involved in liver carcinogenesis. PMID: 25938538
    14. Meta-analysis results provide evidence that HDGF may be a new indicator of poor cancer prognosis. PMID: 25773828
    15. HDGF contains conserved N-terminal HATH domains with a characteristic structural motif, namely the PWWP motif. This study defines the role of the first residue of the PWWP motif in modulating HATH domain stability and oligomer formation in binding. PMID: 26067205
    16. HDGF overexpression is common in early-stage cervical adenocarcinoma. PMID: 25421244
    17. The expression level of hepatoma-derived growth factor (HDGF) significantly decreased in response to the virus-associated RNAs under replication-deficient condition. PMID: 25275311
    18. HDGF can promote IHCC cells progression, including proliferation, invasion, and angiogenesis PMID: 25262276
    19. Results suggest that HDGF downregulation significantly suppresses glioma cell proliferation, migration, invasion in vitro and tumorigenesis in vivo is probably involved in the activation of both the PI3K/Akt and the TGF-beta signaling pathways PMID: 24986090
    20. These data suggested that irradiated fibroblasts promoted invasion, growth, EMT and HDGF expression of ESCC. PMID: 25677618
    21. The expression of nuclear HDGF might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma. PMID: 25071353
    22. HDGF is a potential unfavorable factor for the progression and prognosis of endometrial carcinoma. PMID: 24692842
    23. Data indicate that hepatoma-derived growth factor (HDGF) was a target of miR-195 in non-small cell lung cancer (NSCLC) cells. PMID: 24891187
    24. expression of HDGF was negatively correlated with miR-141 in gastric cancer tissues: the suppressive effects of miR-141 on GC cell proliferation, colony formation, in vitro migration, and invasion were partially mediated by suppressing HDGF expression. PMID: 24276755
    25. ADAM9 high expression is correlated positively and significantly with HDGF high expression in non-small cell lung cancer. PMID: 24770635
    26. Patients with higher HDGF and CD31 expression level had poorer overall survival rates. PMID: 23771798
    27. Positive expression of HDGF was detected in 46.2 % of patients with extrahepatic cholangiocarcinoma and correlated with poor tumor differentiation. The HDGF expression group had lower survival than the negative HDGF expression group. PMID: 23793608
    28. Combining p53 expression and HDGF expression significantly improved prognostic stratification for patients with Ewing family tumor. PMID: 24072730
    29. Together, these results indicate that HDGF downregulation participates in POMC-induced suppression of metastasis and EMT in melanoma. PMID: 23468531
    30. Suggest that HDGF exhibits oncogenic properties and may be a novel prognostic factor in Ewing's sarcoma. PMID: 23878072
    31. Up-regulation of hepatoma-derived growth factor facilities tumor progression in malignant melanoma. PMID: 23536873
    32. The suppressive effect of miR-16 on cell proliferation, colony formation, migration, and invasion is partially mediated by inhibiting HDGF expression. PMID: 23954293
    33. Studied HDGF in gallbladder cancer (GBC).Patients with nuclear HDGF-pos tumors had worse survival than patients with HDGF-negative tumors. Treatment of GBC-SD and SGC-996 lines with HDGF-siRNA significantly reduced the proliferation of GBC cell lines. PMID: 23609195
    34. Tumor samples from non-small cell lung cancers show an inverse relationship between microRNA-497 and HDGF levels, and ectopic expression of miR-497 significantly inhibited tumor growth and angiogenesis in a xenograft model PMID: 23673296
    35. Expression of a cytosolic variant of hepatoma-derived growth factor causes a redistribution of nucleolin into the cytoplasm. PMID: 23305559
    36. Hepatoma-derived growth factor regulates breast cancer cell invasion by modulating epithelial--mesenchymal transition. PMID: 22247069
    37. Hepatoma-derived growth factor overexpression contributes to the oncogenic processes in oral cancer cells PMID: 22361040
    38. Differential proteomic analysis of human glioblastoma and neural stem cells reveals HDGF as a novel angiogenic secreted factor PMID: 22331796
    39. High hepatoma-derived growth factor is associated with gliomas. PMID: 22037800
    40. The interactome suggests that HDGF is a multifunctional protein and participates in many cellular events, including ribosome biogenesis, RNA processing, DNA damage repair and transcriptional regulation. PMID: 21907836
    41. found that HDGF was overexpressed also in primary gastric, breast, and lung cancer tissues harboring mutant p53 genes PMID: 22006999
    42. HDGF was highly expressed in 158 non-small cell lung cancer tissues compared with normal control. PMID: 21426662
    43. High HDGF is associated with hilar cholangiocarcinoma. PMID: 20848225
    44. Increased nuclear expression of HDGF is a potential unfavourable prognostic factor for patients with hepatoma-derived growth factor PMID: 21255068
    45. High HDGF expression is associated with poor overall survival in patients with hepatocellular carcinoma. Down-regulation of HDGF inhibits the growth, anchorage-independent growth, migration and invasion of HepG2 cells. PMID: 20846397
    46. High hepatoma-derived growth factor is associated with colorectal carcinoma. PMID: 19924574
    47. results suggest that HDGF is involved in cell growth, cell invasion, and apoptosis PMID: 21302807
    48. The present study is aimed at examining the role of HDGF in keloid pathogenesis. PMID: 19432814
    49. HDGF expression is upgraded in postoperative stage I non-small cell lung cancer patients, and is a significantly independent predictive factor. PMID: 18478933
    50. Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus PMID: 11751870

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  • 亞細胞定位：
    [Isoform 1]: Nucleus. Cytoplasm. Secreted, extracellular exosome.; [Isoform 2]: Nucleus. Cytoplasm. Secreted, extracellular exosome.; [Isoform 3]: Nucleus. Cytoplasm. Secreted, extracellular exosome.
  • 蛋白家族：
    HDGF family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 4856

    OMIM: 600339

    KEGG: hsa:3068

    STRING: 9606.ENSP00000357189

    UniGene: Hs.743948



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