在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. GSS Recombinant Monoclonal Antibody

GSS Recombinant Monoclonal Antibody

  • 中文名稱：
    GSS Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA188887A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: HEK293 whole cell lysate(30μg), Hela whole cell lysate(30μg), PC-3 whole cell lysate(30μg), HepG2 whole cell lysate(30μg), SH-SY5Y whole cell lysate(30μg), A431 whole cell lysate(30μg), Mouse liver tissue lysate(30μg), Rat liver tissue lysate(30μg), Mouse lung tissue lysate(30μg)
      All lanes: GSS antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 52 kDa
      Observed band size: 52 kDa
      Exposure time：2min
    • Immunofluorescence staining of A549 cell with CSB-RA188887A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Overlay Peak curve showing A431 cells stained with CSB-RA188887A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    GSS
  • 別名：
    Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase), GSS
  • 反應種屬：
    Human, Mouse, Rat
  • 免疫原：
    A synthesized peptide from human GSS protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2H9
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes.
  • 基因功能參考文獻：
    1. Data suggest that the potential of clusterin and glutathione synthetase (GSH-S) as platelet biomarkers for early detection of colorectal cancer (CRC) could improve existing screening modalities in clinical application. PMID: 28849249
    2. Mutation in Glutathione Synthase gene is associated with chronic metabolic acidosis in glutathione synthetase deficiency. PMID: 26669244
    3. Four SNPs (rs7265992, rs6060124, rs7260770, and rs4911455) in GSS were significantly associated with bladder cancer recurrence after transurethral resection and BCG treatment. PMID: 25851338
    4. In this study, clinical, biochemical, and genetic aspects of five Chinese 5-oxoprolinuria patients with OPLAH or GSS gene mutations were investigated. PMID: 25851806
    5. Studied the role of protein-protein interactions in the structural stability, activity and allostery of enzymes using the obligate homodimer human glutathione synthetase as an ideal model. PMID: 25070563
    6. The findings indicate that Asp458 is essential for hGS catalysis and that it impacts the allostery of hGS. PMID: 21771585
    7. These results imply that residues V44 and V45 are integral to the stability of human glutathione synthetase. PMID: 21683691
    8. We have shown that susceptibility to health effects of air pollution on lung function growth is associated with genetic variation in the GSS gene PMID: 20802163
    9. Single-nucleotide polymorphism in glutathione synthetase is associated with small-cell lung cancer. PMID: 20439344
    10. This research indicates that Gly369 and Gly370 have essential roles in hGS, while Gly371 has a lesser involvement. PMID: 20800579
    11. the cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase PMID: 20413906
    12. A novel alternative splicing variant (ASV) of the GSS gene was identified in 10 human normal tissues and five human cancer cell lines. PMID: 19672693
    13. Glutathione synthetase deficiency: is gamma-glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione? PMID: 12638941
    14. analysis of conserved residues of human glutathione synthetase PMID: 14990577
    15. The cloning and characterization of a 2.2 kb 5'-flanking region of the human glutathione synthetase gene is reported. PMID: 15890065
    16. glutathione synthetase autosomal mutations result in glutathione synthetase deficiency, which may cause progressive retinal dystrophy with hyperpigmentations and maculopathy [case report] PMID: 17206463
    17. Glutathione synthase expression may indicate better survival in early stage adenocarcinoma of the lung, and manipulation of glutathione synthase may be a potential basis for treatment of some non-small cell lung cancers. PMID: 17234469
    18. Severe glutathione synthetase deficiency is associated with progressive retinal dystrophy of the rod-cone type, affecting the central retina with advanced macular edema in adulthood. PMID: 19111905

    顯示更多

    收起更多

  • 相關疾病：
    Glutathione synthetase deficiency (GSS deficiency); Glutathione synthetase deficiency of erythrocytes (GLUSYNDE)
  • 蛋白家族：
    Eukaryotic GSH synthase family
  • 數據庫鏈接：

    HGNC: 4624

    OMIM: 231900

    KEGG: hsa:2937

    STRING: 9606.ENSP00000216951

    UniGene: Hs.82327



主站蜘蛛池模板： 精品欧美аv高清免费视频| 白嫩日本少妇做爰| 韩国精品无码少妇在线观看| 野外被强j到高潮免费观看| 国产无套露脸在线观看| 国产sm调教视频在线观看| 亚洲aⅴ综合色区无码一区| 久久久噜噜噜久久熟女| 国产v在线在线观看视频免费| 九色porny丨自拍视频| 欧美成人猛片aaaaaaa| 国产精品人人妻人人爽| 亚洲中文字幕不卡无码| 精品久久久无码人妻中文字幕豆芽| 黑人大荫蒂老太大| 欧美性欧美巨大黑白大战| 亚洲性色成人av| 性欧美老妇另类xxxx| 国产无套内射久久久国产| 狠狠色丁香婷婷综合尤物 | 欧美成人精品 一区二区三区| 浓毛欧美老妇乱子伦视频| 无码福利一区二区三区| 亚洲人成网站在线播放影院在线| 精品国产第一福利网站| 欧美顶级少妇做爰hd| 久久777国产线看观看精品 | 亚洲国产精品久久久久久久| 熟妇女人妻丰满少妇中文字幕| 久青草国产97香蕉在线影院| 亚洲精品高清国产一久久| 欧美饥渴熟妇高潮喷水水| 风流少妇按摩来高潮| 久热这里只有精品99| 久久狠狠色噜噜狠狠狠狠97| 2020精品国产自在现线看| 正在播放东北夫妻内射| 热re99久久6国产精品免费| 67194熟妇在线观看线路| 亚洲欧洲成人av每日更新| 大胸美女污污污www网站|