在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. GRSF1 Recombinant Monoclonal Antibody

GRSF1 Recombinant Monoclonal Antibody

  • 中文名稱：
    GRSF1 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA083965A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing HepG2 cells stained with CSB-RA083965A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    GRSF1
  • 別名：
    G-rich sequence factor 1 (GRSF-1), GRSF1
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide from human GRSF1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    8E7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome. G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA.
  • 基因功能參考文獻：
    1. Deletion of either of the three GRSF1 quasi-RNA-recognition motifs (qRRMs) severely impairs RNA-binding. PMID: 29288125
    2. Data show that some of the naturally occurring guanine-rich RNA sequence binding factor 1 (GRSF1) mutants exhibited a strongly reduced RNA-binding activity although the general protein structure was hardly affected. PMID: 29366917
    3. HuR and GRSF1 govern the cytoplasmic and mitochondrial localization of the lncRNA RMRP, which is encoded by nuclear DNA but has key functions in mitochondria. PMID: 27198227
    4. MiR-346 depends on GRSF1 to upregulate another target gene. PMID: 26507454
    5. Grsf1 controls translation of the protein Use1, possibly by positioning the 40S ribosomal subunit and associated translation factors in front of the translation start site. PMID: 25184340
    6. The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression. PMID: 23473033
    7. GRSF1 regulates RNA processing in mitochondrial RNA granules. PMID: 23473034
    8. GRSF-1 functions by selectively recruiting cellular and viral mRNAs containing 5' UTR GRSF-1 binding sites to polyribosomes, which is mediated through interactions with cellular proteins PMID: 12239318

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Mitochondrion matrix.; [Isoform 2]: Cytoplasm.
  • 數據庫鏈接：

    HGNC: 4610

    OMIM: 604851

    KEGG: hsa:2926

    STRING: 9606.ENSP00000254799

    UniGene: Hs.309763



主站蜘蛛池模板： 欧美成aⅴ人高清ww| 无码av中文字幕免费放 | 日韩 无码 偷拍 中文字幕| 韩国乱码片免费看| 亚洲国产成人精品无码区花野真一| 波多野结衣超清无码专区| 好男人在线社区www在线影院| 久久综合亚洲色hezyo社区| 国产老熟女网站| 免费国产a国产片高清网站| 亚洲日韩色在线影院性色| 亚洲一线二线三线品牌精华液久久久 | 久久不见久久见免费视频观看| 一区二区三区在线 | 欧洲| 国产精品无码mv在线观看| 国产人妻精品区一区二区三区 | 手机看黄av免费网址| 800av凹凸视频在线观看| 国产成人精品电影在线观看| 使劲快高潮了国语对白在线| 国内揄拍国内精品对白86| 亚洲精品国产美女久久久99 | 国产无遮挡a片又黄又爽漫画| 国产亚洲精品成人aa片新蒲金| 亚洲国产一区二区三区波多野结衣| 亚洲永久精品ww47| 精品亚洲成a人在线观看青青| 热re99久久6国产精品免费| 国产老熟妇精品观看| 欧洲亚洲精品久久久久| 777精品出轨人妻国产| 日韩一卡二卡三卡四卡免费观在线 | 日日摸天天爽天天爽视频| 亚洲欧美日韩中文无线码| 无码国模大尺度视频在线观看| 亚洲精品av无码喷奶水网站| 日本不卡一区| 国产精品久久久久久妇女| 亚洲中文欧美在线视频| 精品日产一卡2卡三卡4卡在线| 日韩av无码中文字幕|