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CSN2 Recombinant Monoclonal Antibody

  • 中文名稱：
    CSN2重組抗體
  • 貨號：
    CSB-RA959139A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA959139A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA959139A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing HepG2 cells stained with CSB-RA959139A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃.The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSN2 Recombinant Monoclonal Antibody（Code: CSB-RA959139A0HU）是針對COP9信號體復(fù)合體亞基2（CSN2）研發(fā)的高特異性抗體，該靶點通過調(diào)控泛素-蛋白酶體系統(tǒng)參與細胞周期進程、DNA損傷修復(fù)及轉(zhuǎn)錄因子活性等關(guān)鍵生物學(xué)過程。本產(chǎn)品經(jīng)ELISA、免疫組化（IHC）和流式細胞術(shù)（FC）等多平臺嚴格驗證，在IHC應(yīng)用中可清晰顯示組織或細胞樣本中CSN2蛋白的定位與表達水平，推薦稀釋比例為1:50-1:200；流式檢測中同樣表現(xiàn)出優(yōu)異的信號分辨能力，推薦使用濃度范圍為1:50-1:200。其重組單克隆特性確保了批次間的高度一致性，適用于探究CSN2在蛋白質(zhì)穩(wěn)定性調(diào)控、腫瘤發(fā)生機制及細胞應(yīng)激反應(yīng)中的功能研究，為發(fā)育生物學(xué)、癌癥信號通路分析等基礎(chǔ)科研領(lǐng)域提供可靠工具。本品僅供科學(xué)研究使用。
  • Uniprot No.：
  • 基因名：
    CSN2
  • 別名：
    Beta-casein, CSN2, CASB
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human CSN2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    29D6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Important role in determination of the surface properties of the casein micelles.
  • 基因功能參考文獻：
    1. Data suggest that neurogenesis in neuronal stem cells is differentially affected by human and bovine beta-casein-derived opioid peptides BCM7 and BCM9; such neurogenic changes are accompanied by changes in glutathione/glutathione disulfide ratio and in S-adenosylmethionine/S-adenosylhomocysteine ratio, indicative of changes in redox and methylation states (including DNA methylation). PMID: 27611101
    2. Exogenous 5-HT decreased beta-casein expression in MCF-12A human mammary epithelial cells and was responsible for inhibiting phosphorylation of STAT5, resulting in a decline in lactational function. PMID: 25087955
    3. The acidic fragment of human Abeta (Abeta1-11) and a phosphorylated fragment of beta-Casein induced tau fibrillization in vitro. PMID: 24364857
    4. Milk congestion gives rise to higher levels of beta-casomorphin-8 in milk and plasma than in lactating women without problems. PMID: 24189037
    5. derivatives of peptide fragment (54-59) exhibit immunosuppressant activity PMID: 19463972
    6. New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors. They might play a role in antiseptic and antiinfectious functions due to cysteine protease inhibition of bacteria and viruses. PMID: 12788072
    7. The RCM-kappa does form concentration-dependent micelles. Also, beta-CN phosphorylation level influences micelle formation. Complexes were low-temperature reversible and RCM-kappa fibrils were seen. PMID: 16947075
    8. a negative cross talk between PR and Stat5a/GR may contribute to the physiological role of progesterone to repress lactogenic hormone induction of the beta-casein gene PMID: 16973758

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Beta-casein family
  • 組織特異性：
    Mammary gland specific. Secreted in milk.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2447

    OMIM: 115460

    KEGG: hsa:1447

    STRING: 9606.ENSP00000341030

    UniGene: Hs.2242



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