在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CSF2RB Recombinant Monoclonal Antibody

  • 中文名稱:
    CSF2RB重組抗體
  • 貨號:
    CSB-RA006047MA1HU
  • 規(guī)格:
    ¥1320
  • 圖片:
    • Immunofluorescence staining of Hela cell with CSB-RA006047MA1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L).
    • Immunofluorescence staining of A549 cell with CSB-RA006047MA1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L).
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    CSF2RB Recombinant Monoclonal Antibody(CSB-RA006047MA1HU)是一款靶向人粒細胞-巨噬細胞集落刺激因子受體β亞基(CSF2RB)的高特異性抗體,適用于科研領(lǐng)域?qū)AK-STAT信號通路及免疫調(diào)控機制的研究。該抗體通過重組技術(shù)制備,具有嚴格的批次一致性,經(jīng)ELISA和免疫熒光(IF)實驗驗證,可在多種實驗體系中特異性識別天然構(gòu)象的CSF2RB蛋白。在IF應(yīng)用中,推薦使用1:50至1:200的稀釋度,可清晰呈現(xiàn)靶蛋白在細胞內(nèi)的定位及表達水平。CSF2RB作為IL-3、IL-5和GM-CSF細胞因子受體的共同信號轉(zhuǎn)導(dǎo)亞基,在造血系統(tǒng)發(fā)育、免疫細胞分化及炎癥反應(yīng)中發(fā)揮關(guān)鍵作用。本產(chǎn)品適用于探究其在造血干細胞調(diào)控、免疫細胞功能研究以及相關(guān)信號通路互作機制中的分子作用,為體外細胞模型或組織樣本的靶點檢測提供可靠工具,尤其適用于免疫學(xué)、血液學(xué)及炎癥相關(guān)的基礎(chǔ)研究領(lǐng)域。
  • Uniprot No.:
  • 基因名:
  • 別名:
    CSF2RB Recombinant Monoclonal Antibody
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human CSF2RB protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    hIgG1
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    9C9
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
  • 基因功能參考文獻:
    1. SYK mediates the actions of EPO and GM-CSF and coordinates with TGF-beta in erythropoiesis. PMID: 28131718
    2. Exome sequencing identified candidate variants, including a missense mutation in DUOX2 that impaired its function and a frameshift mutation in CSF2RB that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals. PMID: 27373512
    3. In a genetic analysis of Ashkenazi Jewish individuals, we associated Crohn's Disease with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor, providing an additional mechanism for alterations to the innate immune response in individuals with Crohn's Disease. PMID: 27377463
    4. VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14 PMID: 23572530
    5. These data suggest that expression of GM-CSF and its receptor subunits by colon tumors may be a useful marker for prognosis PMID: 23108143
    6. JAK kinase binding to betac requires the presence of three critical betac lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling. PMID: 21965659
    7. Over expression of IL-3Ralpha and truncated mutation of hbetac may be involved in proliferation and differentiation block in NB4 cells. PMID: 21176354
    8. Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils PMID: 20705940
    9. The results of the study support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population. PMID: 21247258
    10. Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations [case report] PMID: 21205713
    11. the up-regulation of IL-3Rbeta expression may contribute to the maintenance of proliferation rather than cell differentiation. PMID: 21207215
    12. The beta1 integrin-interacting domain in the extracellular domain of IL-3Rbeta was identified. A fragment of a protein corresponding to domain 4 of IL-3Rbeta prevented IL-3-mediated arterial morphogenesis and endothelial cell migration. PMID: 20802515
    13. the domain 1 D-E loop disulfide of hbetac and beta(IL-3) have roles in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling PMID: 20516062
    14. Two different modes of beta c binding are utilized in the presence of the hIL-3R alpha isoforms. PMID: 20472554
    15. hGM-CSF activation of hGM/beta(c)with or w/o the hbeta(c) subunit, promoted primitive phenotype maintenance, indicating that the hGM Ralpha chain cytosolic domain is needed for differentiation mediated by the hGM Ralpha, beta(c) receptor complex. PMID: 12384414
    16. JAK2 activation mediates cross-talk between extracellular domain mutants of the beta-subunit of the GM-CSF receptor and EpoR PMID: 12488507
    17. Interleukin-3 binding to the human betac receptor involves functional epitopes formed by domains 1 and 4 of different protein chains PMID: 15060062
    18. A minor improvement in resolution has given a clearer indication of the position and stabilization of the key residues Tyr15, Phe79, Tyr347, His349, Ile350 and Tyr403 in the elbow region between domain 1 and domain 4 of the dimer-related molecule. PMID: 16754968
    19. These results suggest that the JAK1-JH7-3 domains are required for interleukin-3 receptor common beta subunit interaction and abolish wild type JAK1 and JAK2-mediated signaling. PMID: 16767694
    20. This study found that several markers (rs2072707, rs2284031 and rs909486)of csf2rb showed sex-specific and family history-dependent associations with schizophrenia. PMID: 17667962
    21. The dynamic role of the common signaling subunit beta c is to prevent IL5alpha and GM-CSF ligand-receptor complexes from rapidly dissociating. PMID: 18294864
    22. The interaction between intercellular adhesion molecule 1 (ICAM-1) and the GM-CSF receptor is essential for GM-CSF-induced eosinophil activation and survival. PMID: 18322230
    23. IL-5-induced effects on betac assembly in the presence of nontagged IL-5Ralpha provide direct evidence that IL-5 can cause higher order rearrangements of betac homo-oligomers PMID: 18326494
    24. Ligand-binding and receptor activation are not critically dependent on individual N-glycosylation sites within the IL-3- and IL-5-receptor common beta-subunit. PMID: 18374598

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Pulmonary surfactant metabolism dysfunction 5 (SMDP5)
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Type I cytokine receptor family, Type 4 subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2436

    OMIM: 138981

    KEGG: hsa:1439

    STRING: 9606.ENSP00000384053

    UniGene: Hs.592192



主站蜘蛛池模板: 玩弄少妇高潮ⅹxxxyw| 中文天堂网www新版资源在线| 久久精品aⅴ无码中文字字幕重口 亚洲精品永久在线观看 | 久久久久人妻精品区一三寸| 亚洲熟妇无码av不卡在线播放 | 中文精品一卡2卡3卡4卡国色| 污18禁污色黄网站免费| 亚洲精品午夜理伦不卡在线观看| 美女露出粉嫩小奶头在视频18禁| 亚洲日本va中文字幕久久| 老太脱裤子让老头玩xxxxx| 免费无码成人av电影在线播放 | 亚洲一区波多野结衣在线| 人妻丰满av无码中文字幕| 337p日本欧洲亚洲大胆张筱雨| 午夜精品一区二区三区的区别| 麻豆国产精品va在线观看| 国产免费人成视频在线播放播| 国产办公室秘书无码精品99| 亚洲日韩av在线观看| 国产精品成人a区在线观看| 精品欧美аv高清免费视频| 日日摸日日碰夜夜爽亚洲| 亂倫近親相姦中文字幕| 亚洲国产成人久久综合下载| 午夜爽爽爽男女免费观看麻豆国产| 国产ww久久久久久久久久| 国产麻豆成人精品av| 免费h动漫无码网站| 国产高清在线精品一区下载| 亚洲精品永久在线观看| 欲求不满邻居的爆乳在线播放| 亚洲成av人片在线观看一区二区三区 | 国产精品人妻在线观看| 欧美性xxxxx极品老少| 亚洲a片国产av一区无码| 久九九精品免费视频| 天天爽夜夜爽人人爽| 国产精品无码无卡无需播放器| 欧美乱妇xxxxxbbbbb| 亚洲中久无码永久在线观看同|