CLEC9A Recombinant Monoclonal Antibody
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中文名稱:CLEC9A Recombinant Monoclonal Antibody
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貨號:CSB-RA740922MA1HU
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規格:¥1320
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圖片:
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其他:
產品詳情
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產品描述:CLEC9A重組單克隆抗體(CUSABIO貨號:CSB-RA740922MA1HU)是一款針對CLEC9A靶點設計的高特異性科研工具。CLEC9A是C型凝集素家族成員,主要表達于樹突狀細胞表面,通過識別死亡細胞釋放的肌動蛋白相關分子參與抗原交叉提呈,在啟動適應性免疫應答中發揮關鍵作用。本抗體經ELISA嚴格驗證,推薦工作稀釋度為1:5000至1:50000,可高效識別天然構象下的靶蛋白,展現優異的靈敏度和低背景特性。適用于體外實驗中對CLEC9A蛋白的定量檢測、免疫調控機制研究以及樹突狀細胞相關功能分析,為免疫學、腫瘤微環境研究及感染性疾病模型構建提供可靠支持。該產品采用重組單克隆抗體技術,確保批次間一致性,適用于需要高重復性的實驗體系。僅供科學研究使用,不適用于臨床診斷或其他用途。
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Uniprot No.:
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基因名:
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別名:C type lectin domain family 9; member A antibody; C-type lectin domain family 9 member A antibody; CLC9A_HUMAN antibody; CLEC9A antibody; DNGR1 antibody; HEEE9341 antibody; PRO34046 antibody; UNQ9341 antibody
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反應種屬:Human
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免疫原:Recombinant Human CLEC9A protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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抗體亞型:hIgG4(S228P)
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純化方式:Affinity-chromatography
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克隆號:9H7
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式:Liquid
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應用范圍:ELISA
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推薦稀釋比:
Application Recommended Dilution ELISA 1:5000-1:50000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相關產品
靶點詳情
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功能:Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
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基因功能參考文獻:
- Clec9a is responsible for the antigen cross-presentation of dendritic cell subsets and may be a target of immunotherapy PMID: 27250027
- findings demonstrate that CLEC9A is a specialized receptor that modulates the innate immune response when there is a mycobacterial infection PMID: 29065139
- Data indicate that blood dendritic cell antigen 3 BDCA3(+) and C-type lectin domain family 9, member A CLEC9A(+) dendritic cells (DC) are of major importance in the induction of anti-viral and anti-tumor immunity. PMID: 24910448
- Activated dendritic cell subsets expressing CD141/CLEA9A/CD1c, likely recruited into the tubulointerstitium, are positioned to play a role in the development of fibrosis and, thus, progression to chronic kidney disease. PMID: 24049150
- study showsn that the DNGR-1 ligand is preserved from yeast to man and corresponds to the F-actin component of the cellular cytoskeleton; identification of F-actin as a DNGR-1 ligand suggests that cytoskeletal exposure is a universal sign of cell damage that can be targeted by the innate immune system to initiate immunity PMID: 22483800
- High expression of DNGR-1 specifically and universally identifies a unique dendritic cells subset in mouse and humans. PMID: 22442345
- propose that Clec9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines. PMID: 22483802
- Data show that CLEC9A is only expressed on immature BDCA3(+) myeloid dendritic cells (mDCs). PMID: 22234694
- For production of cytotoxic T cells, transgenic DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants. PMID: 21677141
- A population of human dendritic cells (DC) that expresses DNGR-1 (CLEC9A) and high levels of BDCA3 and resembles mouse CD8alpha+ DCs in phenotype and function, is characterized. PMID: 20479117
- DC, NK lectin group receptor-1 (DNGR-1) is a C-type lectin of the NK cell receptor group PMID: 18497879
- CLEC9A functions as an activation receptor PMID: 18408006
- analysis of differences between mouse and human Clec9A PMID: 18669894
- CLEC9A functions as a SYK-coupled C-type lectin receptor to mediate sensing of necrosis by the principal dendritic-cell subset involved in regulating cross-priming to cell-associated antigens PMID: 19219027
- The paper cited (J Clin Invest. 2008 Jun;118(6):2098-110) is the first characterization of human and mouse CLEC9A (a.k.a DNGR-1) PMID: 18497879
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亞細胞定位:Membrane; Single-pass type II membrane protein.
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組織特異性:In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.
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數據庫鏈接:
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