在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. CENPC Recombinant Monoclonal Antibody

CENPC Recombinant Monoclonal Antibody

  • 中文名稱：
    CENPC Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA952093A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in:JURKAT whole cell lysate(30μg), HL-60 whole cell lysate(30μg), NIH/3T3 whole cell lysate(30μg)
      All lanes: CENPC antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 107 kDa
      Observed band size: 120 kDa
      Exposure time：1min
    • Overlay Peak curve showing jurkat cells stained with CSB-RA952093A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CENPC
  • 別名：
    CENP-C 1 antibody; CENP-C antibody; CENPC_HUMAN antibody; CENPC1 antibody; Centromere autoantigen C antibody; Centromere autoantigen C1 antibody; Centromere protein C 1 antibody; Centromere protein C antibody; hcp-4 antibody; ICEN7 antibody; Interphase centromere complex protein 7 antibody; MIF2 antibody
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    A synthesized peptide derived from human CENPC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    4E2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
  • 基因功能參考文獻：
    1. Whereas CENP-C recruits a single MIS12:NDC80 complex, the authors show here that CENP-T binds one MIS12:NDC80 and two NDC80 complexes upon phosphorylation by the mitotic CDK1:Cyclin B complex at three distinct CENP-T sites. PMID: 28012276
    2. CENP-C specifically binds alpha satellite non-coding RNAs. PMID: 28787590
    3. A nonhistone centromere protein, CENP-C, binds and reshapes the nucleosome, sliding the DNA gyres back to positions similar to those in canonical nucleosomes containing conventional histone H3. PMID: 26878239
    4. HPV18 E7 inhibited the binding of CENP-C to alpha-satellite DNAs. PMID: 25997930
    5. CENP-C recruits the Ndc80 complex through its interactions with KNL1 and the Mis12 complex at kinetochores during chromosome segregation. PMID: 25660545
    6. CENP-C, a CCAN subunit, is crucial for kinetochore assembly because it links centromeres with the microtubule-binding interface of kinetochores. PMID: 26124289
    7. CENP-C affects nucleosome shape and dynamics in a manner analogous to allosteric regulation of enzymes. CENP-C depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity. PMID: 25954010
    8. CENP-C works as an important factor for centromeric M18BP1 recruitment PMID: 22540025
    9. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. PMID: 21353556
    10. CENP-C may target the centromere by establishing multiple contacts with both the DNA and protein constituents of the kinetochore PMID: 12490152
    11. CENPC target sites that can be sumoylated by SUMO-2 were shown to be equally susceptible to SUMO-1 attachments which include specific sites on SUMO-2 itself, Ubc9, and the recombinant CENP-C fragments PMID: 15272016
    12. a functional interplay between the chromosomal passenger complex and CENP-C. PMID: 17287400
    13. Using protein truncation and in vitro mutagenesis, we have identified the nucleolar localization sequences on CENPC1,and evidence shows that CENPC1 is an RNA-associating protein that binds alpha-satellite RNA by an in vitro binding assay. PMID: 17623812
    14. CENP-C and CENP-H co-localize to the CENP-A chromatin domain. PMID: 17651496
    15. DNMT3B interacts with CENP-C to modulate DNA methylation and the histone code at centromere. PMID: 19482874
    16. C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation PMID: 19503796

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere.
  • 蛋白家族：
    CENP-C/MIF2 family
  • 數據庫鏈接：

    HGNC: 1854

    OMIM: 117141

    KEGG: hsa:1060

    STRING: 9606.ENSP00000273853

    UniGene: Hs.479867



主站蜘蛛池模板： 特级无码毛片免费视频播放▽| 伊人久久大香线蕉无码| 轻点好疼好大好爽视频| 日日噜噜夜夜狠狠视频| 97久久超碰国产精品最新| 国产成人18黄网站在线观看| 无码午夜福利免费区久久| 吃奶呻吟打开双腿做受动态图 | 国产精品毛片va一区二区三区| 中文乱码人妻系列一区| 亚洲综合av一区二区三区| 人妻熟女一区二区aⅴ林晓雪| 女人张开双腿让男人猛桶| 在线精品视频一区二区三四| 久久亚洲精品无码va白人极品| 久久精品亚洲日本波多野结衣| 中文字幕无码专区一va亚洲v专区在线| 国产成人久久av免费看| 宅女午夜福利免费视频| 亚洲久悠悠色悠在线播放| yyyy11111少妇影院| 中国美女牲交视频| 男女18禁啪啪无遮挡| 伊人www22综合色| 国产片精品av在线观看夜色| 欧洲国产精品无码专区影院| 亚洲性久久久影院| 一色屋精品视频在线观看| 色九月亚洲综合网| 亚洲s久久久久一区二区| www一区二区www免费| 亚洲一卡一卡二新区无人区| 少妇爆乳无码专区网站| 国产一区二区三区在线观看免费| 亚洲精品一品区二品区三品区| 天堂在线www中文| 99久久国产综合精品五月天喷水| 国产亚洲精品久久久久久久久动漫| 亚洲精品人成网线在线播放va| 宅男色影视亚洲人在线| 日本熟妇浓毛|