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CDX1 Recombinant Monoclonal Antibody

  • 中文名稱：
    CDX1重組抗體
  • 貨號(hào)：
    CSB-RA987794A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate
      All lanes: CDX1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 29, 15 kDa
      Observed band size: 25-30 kDa
    • Immunofluorescence staining of Hela cell with CSB-RA987794A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 524-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CDX1 Recombinant Monoclonal Antibody（CSB-RA987794A0HU）是針對(duì)CDX1蛋白研發(fā)的高特異性抗體。CDX1是Caudal型同源框轉(zhuǎn)錄因子家族成員，在胚胎腸道發(fā)育、腸道上皮細(xì)胞分化及穩(wěn)態(tài)維持中發(fā)揮關(guān)鍵作用，其表達(dá)異常與結(jié)直腸腫瘤發(fā)生密切相關(guān)。本抗體經(jīng)ELISA、Western Blot（WB）和免疫熒光（IF）嚴(yán)格驗(yàn)證，在WB實(shí)驗(yàn)中可特異性識(shí)別CDX1蛋白，推薦使用稀釋度為1:500-1:2000，能清晰檢測目標(biāo)條帶且背景信號(hào)低；IF實(shí)驗(yàn)推薦稀釋度1:50-1:200，可精準(zhǔn)定位細(xì)胞核內(nèi)CDX1蛋白，染色結(jié)果重復(fù)性優(yōu)異。該產(chǎn)品適用于研究腸道發(fā)育調(diào)控機(jī)制、上皮細(xì)胞分化路徑及腫瘤相關(guān)信號(hào)通路，可支持體外細(xì)胞模型、組織切片樣本等多場景分析，為消化道疾病的基礎(chǔ)研究提供可靠工具。
  • Uniprot No.：
  • 基因名：
    CDX1
  • 別名：
    Homeobox protein CDX-1 (Caudal-type homeobox protein 1), CDX1
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human CDX1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    11E10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.
  • 基因功能參考文獻(xiàn)：
    1. XIST is down-regulated in breast cancer and suppresses breast cancer cell growth, migration, and invasion via the miR-155/CDX1 axis. caudal-type homeobox 1 (CDX1) was identified as a direct target of miR-155 and miR-155/CDX1 rescued the effects of XIST in breast cancer cells. PMID: 29550489
    2. Results identified CDX1 as cis methylation quantitative trait loci in allergic rhinitis. PMID: 28149331
    3. Downregulation of CDX1 is associated with recurrence in hepatocellular carcinoma. PMID: 27566019
    4. Data indicate an association between highly fucosylated glycans and caudal type homeobox 1 (CDX1) and/or villin mRNA expression that both correlate with cell differentiation. PMID: 26537799
    5. Changes in CDX1/CDX2 mRNA expression in gastric mucosa following H. pylori eradication showed only insignificant results PMID: 26841784
    6. CDX1 restricts the invasion of HTR-8/SVneo trophoblast cells by inhibiting MMP-9 expression independently of the PI3K/AKT pathway. PMID: 24836459
    7. Results showed an anti-growth effect of CDX1 and identified its miRNA regulatory mechanism in gastric cancer. PMID: 23353818
    8. Certain SNPs of Cdx1 and Cdx2 and their interactions with other risk factors are associated with Barrett's esophagus (BE) and may contribute to human susceptibility to BE. PMID: 23918153
    9. The differential regulation of the gene expression of CDX1, CDX2 and SOX2 in patients with gastric cancer affects not only the tumour but also the non-neoplastic tumour-distant mucosa. PMID: 23613102
    10. Oxidative stress regulates CDX1 expression in T84 colorectal cancer cells. PMID: 23618814
    11. The findings represented the relation between CDX1 mutations and CDX1 genotype. Furthermore, it was suggested that the downregulation of CDX1 might be related to the development of Anorectal malformations . PMID: 23329892
    12. analysis of an IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma PMID: 23185413
    13. The homeotic transcription factor CDX1 is expressed in the intestinal epithelium at all stages of development. Review. PMID: 23127929
    14. The epigenetic inactivation of CDX1 by promoter methylation, as well as the functional link of CDX1 promoter methylation to the inflammatory NF-kappaB signaling pathway, were investigated. PMID: 22749770
    15. The human ASBT promoter was activated transcriptionally by CDX1 and CDX2. PMID: 22016432
    16. Expression of CDX1 and CDX4 is not correlated with the pathogenesis and relapse of adult ALL. PMID: 21518475
    17. CDX1 and CDX2 in cancer group was significantly higher than control group PMID: 21532856
    18. RNA interference of CDX1 and CDX2 and chromatin immunoprecipitation in colon cancer cells revealed that MS4A12 transcript and protein expression is essentially dependent on the presence of endogenous CDX2. PMID: 19781065
    19. Our data suggested an important role of CDX1 and CDX2 in the development of Barrett's esophagus PMID: 19468668
    20. Increased CDX1 mRNA expression is associated with chronic atrophic gastritis PMID: 11846061
    21. CDX1 is downregulated after promoter methylation in colorectal tumor cell lines PMID: 12124393
    22. these data show that Cdx1 exhibits a complex pattern during colorectal cancer progression, a high level of expression in polyps, and in one-third of the specimens, suggest that this gene may be a factor in the process toward malignant transformation PMID: 12970739
    23. absence of CDX1 mRNA expression in 7 of 37 CRC cell lines and shown that all 7 cell lines have a methylated CDX1 promoter PMID: 14704280
    24. Upstream sequences contain regulatory elements directing transgene expression specifically to intestinal epithelium. Two active chromatin regions in CDX1 gene may function as potential intestine-specific enhancers. PMID: 14715525
    25. Cdx1 and Cdx2 inhibit colon cancer cell proliferation by blocking beta-catenin/TCF transcriptional activity PMID: 15215241
    26. Cdx1 activates the IAP gene via a novel cis element, whereas Cdx2 inhibits the Cdx1 effects PMID: 15774940
    27. Demethylation of the CDX1 promoter may be the key to the induction and maintenance of its expression and so of the Barrett's metaplasia phenotype. PMID: 15894614
    28. changes in CDX2 and CDX1 expression determined by methyl group deprivation may constitute one of the mechanisms sustaining the protective role attributed to folate in colon cancer PMID: 18187048
    29. Cdx1 is not an oncogene in normal intestinal epithelium. PMID: 18231635
    30. The ability of Cdx1 and c-myc to initiate the earliest stages of transdifferentiation of esophageal keratinocytes toward a cell fate characteristic of Barrett's esophagus. PMID: 18953412
    31. CDX1 enhanced the expression of PPARgamma gene, a master transcriptional regulator of intestinal differentiation, at the transcriptional level, via functional interaction with CCAAT/enhancer-binding protein alpha (C/EBPalpha). PMID: 19059241
    32. KRT20 is directly regulated by CDX1, suggesting a role for CDX1 in maintaining differentiation in intestinal epithelial cells PMID: 19188603

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Caudal homeobox family
  • 組織特異性：
    Intestinal epithelium.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1805

    OMIM: 600746

    KEGG: hsa:1044

    STRING: 9606.ENSP00000231656

    UniGene: Hs.1545



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