在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDKN2C Recombinant Monoclonal Antibody

  • 中文名稱:
    CDKN2C Recombinant Monoclonal Antibody
  • 貨號(hào):
    CSB-RA580611A0HU
  • 規(guī)格:
    ¥1320
  • 圖片:
    • Overlay Peak curve showing jurkat cells stained with CSB-RA580611A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6), CDKN2C, CDKN6
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    A synthesized peptide from human CDKN2C protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Rabbit IgG
  • 純化方式:
    Affinity-chromatography
  • 克隆號(hào):
    2D11
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, FC
  • 推薦稀釋比:
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
  • 基因功能參考文獻(xiàn):
    1. Low P18 expression is associated with multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors. PMID: 29134609
    2. Cycling hypoxia could induce significant changes in CLDN1 and CLDN7 expression in nasopharyngeal cancer cells, indirectly regulation P18 expression and affecting cell invasion/proliferation. PMID: 28055967
    3. genetic association studies in population in Houston TX: Data suggest that CDKN2C copy number variations are associated with sporadic medullary thyroid carcinoma; these associations include presence of distant metastasis at presentation and decreased overall survival. PMID: 27610696
    4. CDKN2C gene deletion is associated with plasma cell post-transplantation lymphoproliferative disorders. PMID: 27750397
    5. Our study suggests that p18 is a limiting factor for the noncanonical HSC differentiation path in lymphoid lineages. PMID: 27287689
    6. CDKN2C inactivation contributes to the leukemogenesis in acute promyelocytic leukemia. PMID: 27888400
    7. DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18INK4C in gastric carcinogenesis PMID: 26350239
    8. Data suggest that cell cycle-dependent kinase inhibitors CDKN2C/p18 and CDKN1A/p21 facilitate cell cycle entry/cell proliferation of quiescent adult human pancreatic beta cells in primary culture (from tissues obtained from organ donors). PMID: 26740620
    9. Mutations in CDKN2C is associated with sporadic parathyroid adenoma. PMID: 24127162
    10. Analysis of B1a lymphocyte phenotypes of p18-deficient C57BL/6 mice finds that p18 is a key regulator of the size of the B1a cell pool. PMID: 22896639
    11. up-regulated HULC promotes proliferation of hepatoma cells through suppressing p18 PMID: 22685290
    12. Data indicate that the role of CDKN2C in the adverse outcome of cases with hemizygous deletion was less certain. PMID: 21994415
    13. results demonstrate for the first time that N-Myc is a downstream target of RET2A signaling, and propose that induction of N-Myc by RET2A is a key step leading to lower p18 levels during MEN2A tumorigenesis PMID: 21112821
    14. conclude that E2F proteins and Sp1 play an important role in the control of p18 expression PMID: 12077144
    15. Deletions in the CDKN2C locus and hypermethylation in the CDKN2C promoter region play a role in ovarian granulosa cell tumorogenesis. PMID: 12203782
    16. p18INK4c may function as a tumor suppressor in Hodgkin lymphoma, and inactivation may contribute to cell cycle deregulation and defective terminal differentiation of the Reed-Sternberg cells. PMID: 14645011
    17. protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c) PMID: 15107819
    18. p18(INK4C) loss may contribute to medulloblastoma formation in children PMID: 16260494
    19. oncogenic RET and loss of p18 cooperate in the multistep tumorigenesis of medullary thyroid carcinoma PMID: 18316595
    20. NaBu-mediated p18( INK4C ) regulation played a role in cell cycle arrest and erythroid differentiation in K562 cells. PMID: 18642058
    21. deletions of CDKN2C are important in the progression and clinical outcome of myeloma PMID: 18829482
    22. P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma PMID: 18942719
    23. Purpose was to investigate genetic alterations of CDKN2C gene in 38 pituitary adenomas. The absence of CDKN2C protein was correlated with LOH of the CDKN2C locus on chromosome 1 and with methylation of the CDKN2C promoter. PMID: 18973139
    24. The down-regulation of p18(INK4C) expression may contribute to the tumorigenesis of pituitary adenomas. PMID: 19401813
    25. p18(INK4C) is a downstream target of GATA3, constrains luminal progenitor cell expansion, and suppresses luminal tumorigenesis in the mammary gland PMID: 19411068
    26. Results identified a molecular basis for CDK inhibitors to exert an antitumor effect in p18-deficient cancers and support the clinical use of CDK inhibitors. PMID: 19509251

    顯示更多

    收起更多

  • 蛋白家族:
    CDKN2 cyclin-dependent kinase inhibitor family
  • 組織特異性:
    Highest levels found in skeletal muscle. Also found in pancreas and heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1789

    OMIM: 603369

    KEGG: hsa:1031

    STRING: 9606.ENSP00000262662

    UniGene: Hs.525324



主站蜘蛛池模板: 无遮挡很爽很污很黄的网站| 国产成人精品午夜福利在线观看 | 人妻无码久久精品人妻| 国产免费一区二区视频| 国产精品一区二区在线蜜芽tv| 亚洲国产av导航第一福利网| 亚洲中文字幕无码不卡电影| 国产又粗又猛又大爽老大爷| 亚洲 综合 欧美 动漫 丝袜| 久久精品女同亚洲女同| 中文字幕久久熟女人妻av免费| 色翁荡息又大又硬又粗又爽电影| 人妻av无码系列专区移动可看| 免费福利视频一区二区三区高清 | 久久久久女教师免费一区| 亚洲香蕉视频天天爽| 色哟哟免费视频播放网站| 国产三级韩国三级日产三级| 99精品全国免费观看视频| 欧美怡红院免费全部视频| 日日摸天天摸爽爽狠狠97| 国产成人av国语在线观看| 无遮挡很爽很污很黄的网站| 丁香花在线影院观看在线播放| 久久精品免视看国产成人明星| 又黄又湿啪啪响18禁| 国产乱人伦中文无无码视频试看 | 免费无码又爽又高潮视频| 少妇白浆高潮无码免费区| 久久亚洲国产精品123区| 日本丰满人妻xxxxxhd| 国产成人精品一区二区三区视频| 中文乱码字幕视频观看网站免费| 日本真人边吃奶边做爽免费视频| 国产精品成人免费视频网站京东| 国语对白做受xxxxx在线中国 | 四虎国产精亚洲一区久久特色| 亚洲欧洲日产国产 最新 | 69sex久久精品国产麻豆| 香蕉在线精品视频在线| 国内精品一区二区三区不卡|